UniProtKB - Q3SHT1 (ASSY_THIDA)
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Protein
Argininosuccinate synthase
Gene
argG
Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Functioni
Catalytic activityi
ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation
: L-arginine biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Ornithine carbamoyltransferase (argF)
- Argininosuccinate synthase (argG)
- Argininosuccinate lyase (argH)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 37 | ATP; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 90 | CitrullineUniRule annotation | 1 | |
Binding sitei | 95 | CitrullineUniRule annotation | 1 | |
Binding sitei | 120 | ATP; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 122 | AspartateUniRule annotation | 1 | |
Binding sitei | 126 | AspartateUniRule annotation | 1 | |
Binding sitei | 126 | CitrullineUniRule annotation | 1 | |
Binding sitei | 127 | AspartateUniRule annotation | 1 | |
Binding sitei | 130 | CitrullineUniRule annotation | 1 | |
Binding sitei | 182 | CitrullineUniRule annotation | 1 | |
Binding sitei | 191 | CitrullineUniRule annotation | 1 | |
Binding sitei | 267 | CitrullineUniRule annotation | 1 | |
Binding sitei | 279 | CitrullineUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- argininosuccinate synthase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- arginine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Ligase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | TDEN292415:G1G56-1867-MONOMER |
UniPathwayi | UPA00068; UER00113 |
Names & Taxonomyi
Protein namesi | Recommended name: Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)Alternative name(s): Citrulline--aspartate ligaseUniRule annotation |
Gene namesi | Name:argGUniRule annotation Ordered Locus Names:Tbd_1849 |
Organismi | Thiobacillus denitrificans (strain ATCC 25259) |
Taxonomic identifieri | 292415 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Thiobacillaceae › Thiobacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263989 | 1 – 409 | Argininosuccinate synthaseAdd BLAST | 409 |
Interactioni
Subunit structurei
Homotetramer.UniRule annotation
Protein-protein interaction databases
STRINGi | 292415.Tbd_1849 |
Structurei
3D structure databases
ProteinModelPortali | Q3SHT1 |
SMRi | Q3SHT1 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105CDH Bacteria COG0137 LUCA |
HOGENOMi | HOG000230093 |
KOi | K01940 |
OrthoDBi | POG091H01U0 |
Family and domain databases
CDDi | cd01999 Argininosuccinate_Synthase, 1 hit |
Gene3Di | 3.40.50.6202 hits 3.90.1260.102 hits |
HAMAPi | MF_00005 Arg_succ_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001518 Arginosuc_synth IPR018223 Arginosuc_synth_CS IPR023434 Arginosuc_synth_type_1_subfam IPR024074 AS_cat/multimer_dom_body IPR014729 Rossmann-like_a/b/a_fold |
PANTHERi | PTHR11587 PTHR11587, 1 hit |
Pfami | View protein in Pfam PF00764 Arginosuc_synth, 1 hit |
TIGRFAMsi | TIGR00032 argG, 1 hit |
PROSITEi | View protein in PROSITE PS00564 ARGININOSUCCIN_SYN_1, 1 hit PS00565 ARGININOSUCCIN_SYN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3SHT1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDIKKVVLA YSGGLDTSVI LKWLQDTYQC EVVTFTADLG QGEELEPARQ
60 70 80 90 100
KALQFGIKPE QIYIDDLREE FVRDFVFPMF RANTVYEGEY LLGTSIARPL
110 120 130 140 150
IAKRLIEIVN ATGADAICHG ATGKGNDQVR FELGAYALKP DVKVIAPWRE
160 170 180 190 200
WDLLSREKLL AYAESHGIPI DMKHRQGGSP YSMDANLLHI SYEGRHLEDP
210 220 230 240 250
SAEAEEDMWR WTVSPEKAPD AAEYIELTYA KGDVVAIDGQ QMPAHEVLAK
260 270 280 290 300
LNELGGKHGI GRLDLVENRY VGMKSRGCYE TPGGTILLKA HRAIESITLD
310 320 330 340 350
REVAHLKDDL MPRYASLIYN GYWWAPERRA LQVLIDHTQA HVNGTVRLKL
360 370 380 390 400
YKGNVIVVGR DSKNDSLFDS TIATFEDDAG AYDQKDAGGF IKLNALRMRI
AAKLDARRK
Sequence cautioni
The sequence AAZ97802 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000116 Genomic DNA Translation: AAZ97802.1 Different initiation. |
RefSeqi | WP_011312361.1, NC_007404.1 |
Genome annotation databases
EnsemblBacteriai | AAZ97802; AAZ97802; Tbd_1849 |
KEGGi | tbd:Tbd_1849 |
Similar proteinsi
Entry informationi
Entry namei | ASSY_THIDA | |
Accessioni | Q3SHT1Primary (citable) accession number: Q3SHT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 28, 2018 | |
This is version 76 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |