ID   Q3SHJ1_THIDA            Unreviewed;       621 AA.
AC   Q3SHJ1;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=Tbd_1942 {ECO:0000313|EMBL:AAZ97895.1};
OS   Thiobacillus denitrificans (strain ATCC 25259).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Thiobacillaceae; Thiobacillus.
OX   NCBI_TaxID=292415 {ECO:0000313|EMBL:AAZ97895.1, ECO:0000313|Proteomes:UP000008291};
RN   [1] {ECO:0000313|EMBL:AAZ97895.1, ECO:0000313|Proteomes:UP000008291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25259 {ECO:0000313|EMBL:AAZ97895.1,
RC   ECO:0000313|Proteomes:UP000008291};
RX   PubMed=16452431; DOI=10.1128/JB.188.4.1473-1488.2006;
RA   Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA   Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT   "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT   anaerobic bacterium Thiobacillus denitrificans.";
RL   J. Bacteriol. 188:1473-1488(2006).
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DR   EMBL; CP000116; AAZ97895.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3SHJ1; -.
DR   STRING; 292415.Tbd_1942; -.
DR   KEGG; tbd:Tbd_1942; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG0631; Bacteria.
DR   HOGENOM; CLU_034273_0_0_4; -.
DR   Proteomes; UP000008291; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00143; PP2Cc; 1.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF13672; PP2C_2; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51746; PPM_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:AAZ97895.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008291};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:AAZ97895.1};
KW   Transferase {ECO:0000313|EMBL:AAZ97895.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        569..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..258
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   DOMAIN          291..556
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   621 AA;  68468 MW;  063F9A8A74E19138 CRC64;
     MSGTAGRAEA GPAPLAGPAM RGELEVSAGQ YSDRGRKEIN QDFHGIRIPE ATQRRAKGVV
     VALADGISSS TVGHVAAQAA VAGFLEDYFC TPDAWSVKTS AQRVLTALNA WLHAQSQRSP
     YRYERDRGYV CTLSALVVKS ATAHLFHVGD TRIYRLRDGT LEQLTNDHRL RLADDVHYLG
     RALGINAQLE IDYRAEALEA GDVFVLATDG VYEHVAAGFV ADAVATHGDD LDRAAAAIAG
     QAYAQGSADN LTVQILRIDR LPNAGARELR NQLAARPLPP ILQGRMRFDG YTIVREVHGS
     SRSHVYLAVD EESGARVILK APSIELQGEA GYLERFLMEE WVARRVDSAH VLKPSPVRRK
     PGYLYTAMEF VEGQTLGQWM IDHPRPDLET VRGIVEQIAR GLRAFHRLEM LHQDLRPENI
     MIEPNGTVKI IDFGSTEVAG MRETDPLAGR GIELGTLQYT APERLLGDGG TRAADLFALG
     VITYQMLSGE LPYDTQVARY RTRADQRRLR YRSLRDGRRA IPPWVDDAIR KAVHPEPERR
     YENLSEFTFD LRHPSPSRPA SPLIERHPLA FWQGLSLVLA LVVVALAAAL HATRLPATSA
     EPSAERGAAF VSSQPSERRS R
//