Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q3SHA3 (HEMH_THIDA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Tbd_2033
OrganismThiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]
Taxonomic identifier292415 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Ferrochelatase HAMAP MF_00323
PRO_1000072027

Sites

Metal binding2101Iron By similarity
Metal binding2911Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SHA3 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 2EC67A9E7F53292F

FASTA36740,793
        10         20         30         40         50         60 
MKYAEEPEYA HGTPLCAGVL LVNLGTPEAP TAAALRPYLK EFLSDPRVVE IPRALWWLVL 

        70         80         90        100        110        120 
NGIILNTRPR KSAEKYAAIW TSEGSPLKVH TEKQAKLLKG WLGEHAAAPV VVDYAMRYGR 

       130        140        150        160        170        180 
PGIPEVLARM KAAGCDRILV LPAYPQYAAS STATAFDAAF DWLRRTRNQP ALRTLKHYHD 

       190        200        210        220        230        240 
HPEYIRALAA NLRDYWQMHG RPDVLVMSFH GVPRYTLDKG DPYHCECQKT ARLLAAALGL 

       250        260        270        280        290        300 
EPGQFRVTFQ SRFGRAEWLK PYTDKTLEAL GREGVGRVDV VAPGFTADCL ETLEELAMEG 

       310        320        330        340        350        360 
RASFLAAGGK EFHYVPALNE HPQWIAALGR IALANLAGWL DEGWTPDADE ASRQLSRSRA 


LALGAQR

« Hide

References

[1]"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25259.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000116 Genomic DNA. Translation: AAZ97986.1.
RefSeqYP_315791.1. NC_007404.1.

3D structure databases

ProteinModelPortalQ3SHA3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3SHA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3672204.
GenomeReviewsGene locus Tbd_2033 in contig CP000116_GR.
KEGGtbd:Tbd_2033.
NMPDRfig|292415.3.peg.2173.
PATRIC23970241. VBIThiDen82923_2011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBQ3SHA3.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycTDEN292415:TBD_2033-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_THIDA
AccessionPrimary (citable) accession number: Q3SHA3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2005
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents