aat

Functionⁱ

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityⁱ

L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-lysyl-[protein].UniRule annotation

L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-arginyl-[protein].UniRule annotation

L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functionⁱ

leucyltransferase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

protein catabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation) Alternative name(s): L/F-transferaseUniRule annotation LeucyltransferaseUniRule annotation PhenyalanyltransferaseUniRule annotation
Gene namesⁱ	Name:aatUniRule annotation Ordered Locus Names:Tbd_2043
Organismⁱ	Thiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifierⁱ	292415 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus › Thiobacillus denitrificans
Proteomesⁱ	UP000008291 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00688

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000258106	1 – 228	Leucyl/phenylalanyl-tRNA--protein transferaseAdd BLAST		228

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	292415.Tbd_2043.

STRINGⁱ

292415.Tbd_2043.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3SH93.
SMRⁱ	Q3SH93.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108R4Z. Bacteria. COG2360. LUCA.
HOGENOMⁱ	HOG000102325.
KEGG Orthology (KO) More...KOⁱ	K00684.
OMAⁱ	YRQGIFP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H045I.

Family and domain databases

HAMAPⁱ	MF_00688. Leu_Phe_trans. 1 hit.
InterProⁱ	View protein in InterPro IPR016181. Acyl_CoA_acyltransferase. IPR004616. Leu/Phe-tRNA_Trfase.
PANTHERⁱ	PTHR30098. PTHR30098. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03588. Leu_Phe_trans. 1 hit.
SUPFAMⁱ	SSF55729. SSF55729. 1 hit.
TIGRFAMsⁱ	TIGR00667. aat. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3SH93-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKEPFTNASY FPPVETALVD PNGLLAIGGD LSQERLLDAY RHGIFPWFNP 
        60         70         80         90        100
REPIQWWSPD PRMVLPPAEI RVTRSLAKRL RNAGFELRVD SAFIEVMRAC 
       110        120        130        140        150
GAPREGAWGT WISAPMIAAY GRLFDAGYAH SIETWRDGRL VGGLYGVAIG 
       160        170        180        190        200
RMFYGESMFS REPDASKVAL VRLARQLERW GFGLIDCQME TPHLASMGAR 
       210        220 
PIPRADFTAR LAELVNLPHL PGPWTFDS

Length:228

Mass (Da):25,573

Last modified:October 11, 2005 - v1

Checksum:ⁱDF5F323088BCA553

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000116 Genomic DNA. Translation: AAZ97996.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011312555.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAZ97996; AAZ97996; Tbd_2043.
KEGGⁱ	tbd:Tbd_2043.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000116 Genomic DNA. Translation: AAZ97996.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011312555.1. NC_007404.1.

3D structure databases

ProteinModelPortalⁱ	Q3SH93.
SMRⁱ	Q3SH93.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	292415.Tbd_2043.

STRINGⁱ

292415.Tbd_2043.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAZ97996; AAZ97996; Tbd_2043.
KEGGⁱ	tbd:Tbd_2043.

Phylogenomic databases

eggNOGⁱ	ENOG4108R4Z. Bacteria. COG2360. LUCA.
HOGENOMⁱ	HOG000102325.
KEGG Orthology (KO) More...KOⁱ	K00684.
OMAⁱ	YRQGIFP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H045I.

Family and domain databases

HAMAPⁱ	MF_00688. Leu_Phe_trans. 1 hit.
InterProⁱ	View protein in InterPro IPR016181. Acyl_CoA_acyltransferase. IPR004616. Leu/Phe-tRNA_Trfase.
PANTHERⁱ	PTHR30098. PTHR30098. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03588. Leu_Phe_trans. 1 hit.
SUPFAMⁱ	SSF55729. SSF55729. 1 hit.
TIGRFAMsⁱ	TIGR00667. aat. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LFTR_THIDA
Accessionⁱ	Q3SH93Primary (citable) accession number: Q3SH93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 11, 2005
	Last modified:	June 7, 2017
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - Q3SH93 (LFTR_THIDA)

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Leucyl/phenylalanyl-tRNA--protein transferase

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3SH93 (LFTR_THIDA)

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Leucyl/phenylalanyl-tRNA--protein transferase

aat

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ