UniProtKB - Q3SH93 (LFTR_THIDA)
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Protein
Leucyl/phenylalanyl-tRNA--protein transferase
Gene
aat
Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Functioni
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation
Catalytic activityi
L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-lysyl-[protein].UniRule annotation
L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-arginyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation
GO - Molecular functioni
- leucyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- protein catabolic process Source: InterPro
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | TDEN292415:G1G56-2068-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)Alternative name(s): L/F-transferaseUniRule annotation LeucyltransferaseUniRule annotation PhenyalanyltransferaseUniRule annotation |
Gene namesi | Name:aatUniRule annotation Ordered Locus Names:Tbd_2043 |
Organismi | Thiobacillus denitrificans (strain ATCC 25259) |
Taxonomic identifieri | 292415 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Thiobacillaceae › Thiobacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000258106 | 1 – 228 | Leucyl/phenylalanyl-tRNA--protein transferaseAdd BLAST | 228 |
Structurei
3D structure databases
ProteinModelPortali | Q3SH93 |
SMRi | Q3SH93 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the L/F-transferase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108R4Z Bacteria COG2360 LUCA |
HOGENOMi | HOG000102325 |
KOi | K00684 |
OMAi | YRQGIFP |
OrthoDBi | POG091H045I |
Family and domain databases
HAMAPi | MF_00688 Leu_Phe_trans, 1 hit |
InterProi | View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR004616 Leu/Phe-tRNA_Trfase |
PANTHERi | PTHR30098 PTHR30098, 1 hit |
Pfami | View protein in Pfam PF03588 Leu_Phe_trans, 1 hit |
SUPFAMi | SSF55729 SSF55729, 1 hit |
TIGRFAMsi | TIGR00667 aat, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3SH93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEPFTNASY FPPVETALVD PNGLLAIGGD LSQERLLDAY RHGIFPWFNP
60 70 80 90 100
REPIQWWSPD PRMVLPPAEI RVTRSLAKRL RNAGFELRVD SAFIEVMRAC
110 120 130 140 150
GAPREGAWGT WISAPMIAAY GRLFDAGYAH SIETWRDGRL VGGLYGVAIG
160 170 180 190 200
RMFYGESMFS REPDASKVAL VRLARQLERW GFGLIDCQME TPHLASMGAR
210 220
PIPRADFTAR LAELVNLPHL PGPWTFDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000116 Genomic DNA Translation: AAZ97996.1 |
RefSeqi | WP_011312555.1, NC_007404.1 |
Genome annotation databases
EnsemblBacteriai | AAZ97996; AAZ97996; Tbd_2043 |
KEGGi | tbd:Tbd_2043 |
Similar proteinsi
Entry informationi
Entry namei | LFTR_THIDA | |
Accessioni | Q3SH93Primary (citable) accession number: Q3SH93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 28, 2018 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |