aat

Functionⁱ

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityⁱ

L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-lysyl-[protein].UniRule annotation

L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-arginyl-[protein].UniRule annotation

L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functionⁱ

leucyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	TDEN292415:G1G56-2068-MONOMER

BioCycⁱ

TDEN292415:G1G56-2068-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation) Alternative name(s): L/F-transferaseUniRule annotation LeucyltransferaseUniRule annotation PhenyalanyltransferaseUniRule annotation
Gene namesⁱ	Name:aatUniRule annotation Ordered Locus Names:Tbd_2043
Organismⁱ	Thiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifierⁱ	292415 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Thiobacillaceae › Thiobacillus › Thiobacillus denitrificans
Proteomesⁱ	UP000008291 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00688

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000258106	1 – 228	Leucyl/phenylalanyl-tRNA--protein transferaseAdd BLAST		228

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	292415.Tbd_2043

STRINGⁱ

292415.Tbd_2043

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3SH93
SMRⁱ	Q3SH93
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108R4Z Bacteria COG2360 LUCA
HOGENOMⁱ	HOG000102325
KEGG Orthology (KO) More...KOⁱ	K00684
OMAⁱ	YRQGIFP
Database of Orthologous Groups More...OrthoDBⁱ	POG091H045I

Family and domain databases

HAMAPⁱ	MF_00688 Leu_Phe_trans, 1 hit
InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR004616 Leu/Phe-tRNA_Trfase
PANTHERⁱ	PTHR30098 PTHR30098, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03588 Leu_Phe_trans, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
TIGRFAMsⁱ	TIGR00667 aat, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3SH93-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKEPFTNASY FPPVETALVD PNGLLAIGGD LSQERLLDAY RHGIFPWFNP 
        60         70         80         90        100
REPIQWWSPD PRMVLPPAEI RVTRSLAKRL RNAGFELRVD SAFIEVMRAC 
       110        120        130        140        150
GAPREGAWGT WISAPMIAAY GRLFDAGYAH SIETWRDGRL VGGLYGVAIG 
       160        170        180        190        200
RMFYGESMFS REPDASKVAL VRLARQLERW GFGLIDCQME TPHLASMGAR 
       210        220 
PIPRADFTAR LAELVNLPHL PGPWTFDS

Length:228

Mass (Da):25,573

Last modified:October 11, 2005 - v1

Checksum:ⁱDF5F323088BCA553

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000116 Genomic DNA Translation: AAZ97996.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011312555.1, NC_007404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAZ97996; AAZ97996; Tbd_2043
KEGGⁱ	tbd:Tbd_2043

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3SH93	Q30ZK1 A0A2M9DU46 UPI00041687A4 S6BGM1 UPI0009845AF2 F4L6N4 A0A1G1F2F5 UPI00048007D9 A0A1R1I775 A0A1Q4GFQ7 +207	Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20)) Desulfofaba hansenii Desulfuromonas sp. TF Pseudomonas resinovorans NBRC 106553 Pseudomonas resinovorans Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O) Nitrospirae bacterium GWB2_47_37 Desulfovibrio cuneatus Azonexus hydrophilus Thiobacillus sp. 63-78 And more	248	UniRef50_Q30ZK1	Cluster: Leucyl/phenylalanyl-tRNA--protein transferase	218

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000116 Genomic DNA Translation: AAZ97996.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011312555.1, NC_007404.1

3D structure databases

ProteinModelPortalⁱ	Q3SH93
SMRⁱ	Q3SH93
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	292415.Tbd_2043

STRINGⁱ

292415.Tbd_2043

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAZ97996; AAZ97996; Tbd_2043
KEGGⁱ	tbd:Tbd_2043

Phylogenomic databases

eggNOGⁱ	ENOG4108R4Z Bacteria COG2360 LUCA
HOGENOMⁱ	HOG000102325
KEGG Orthology (KO) More...KOⁱ	K00684
OMAⁱ	YRQGIFP
Database of Orthologous Groups More...OrthoDBⁱ	POG091H045I

Enzyme and pathway databases

BioCycⁱ	TDEN292415:G1G56-2068-MONOMER

BioCycⁱ

TDEN292415:G1G56-2068-MONOMER

Family and domain databases

HAMAPⁱ	MF_00688 Leu_Phe_trans, 1 hit
InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR004616 Leu/Phe-tRNA_Trfase
PANTHERⁱ	PTHR30098 PTHR30098, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03588 Leu_Phe_trans, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
TIGRFAMsⁱ	TIGR00667 aat, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LFTR_THIDA
Accessionⁱ	Q3SH93Primary (citable) accession number: Q3SH93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	October 11, 2005
	Last modified:	February 28, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3SH93 (LFTR_THIDA)

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Leucyl/phenylalanyl-tRNA--protein transferase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

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Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ