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Q3SH73 (G6PI2_THIDA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase 2

Short name=GPI 2
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase 2
Short name=PGI 2
Phosphohexose isomerase 2
Short name=PHI 2
Gene names
Name:pgi2
Ordered Locus Names:Tbd_2063
OrganismThiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]
Taxonomic identifier292415 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAZ98016.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Glucose-6-phosphate isomerase 2 HAMAP-Rule MF_00473
PRO_0000230940

Sites

Active site3601Proton donor By similarity
Active site3911 By similarity
Active site5141 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3SH73 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 7A4EAAA90F8EE01B

FASTA55462,388
        10         20         30         40         50         60 
MRTGDTRTSG LSTRPVHRLL QAHHSRMADV HMRELFDTDP QRFERFSLQV GDLLLDYSKN 

        70         80         90        100        110        120 
RITDETMDLL VRMAEESDVA GWRERMFRGD KINTTENRAV LHVALRNRSN RPVNVDGEDV 

       130        140        150        160        170        180 
MPKVNAVIER MGAFAEQVRG GVWRGYSGAL ITDVVNIGIG GSDLGPQMVV QALKPYRHPR 

       190        200        210        220        230        240 
LKLHFISNVD GAHVKETLEA LDPETTLFIV SSKTFTTQET MTNAHYARDW FLARAGDVAH 

       250        260        270        280        290        300 
VARHFVAVST NRDAVTAFGI DAANMFEFWD WVGGRYSLWS AIGLSIVLAV GAERFLELLE 

       310        320        330        340        350        360 
GAHEMDEHFR HAPLRQNMPV ILALLGIWYN NFFGAESHAI LPYDHYLRSL PAYLEQADME 

       370        380        390        400        410        420 
SNGKSVDRDG RVVDYPTGQI IWGATGINGQ HAFYQLLHQG TKMIPADFIV SITPHTELQE 

       430        440        450        460        470        480 
HHDILIANFL AQTEALMRGR TREETLEEMG RSPGDPSVQH RVFEGNHPSN AILLKKLTPH 

       490        500        510        520        530        540 
TLGMLIALYE HKIFVEGVIW NLNSYDQWGV ELGKQLAGRI LPELHADAPV AGHDASTNAL 

       550 
INHYRRMTQP HPGL 

« Hide

References

[1]"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25259.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000116 Genomic DNA. Translation: AAZ98016.1. Different initiation.
RefSeqYP_315821.1. NC_007404.1.

3D structure databases

ProteinModelPortalQ3SH73.
SMRQ3SH73. Positions 9-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292415.Tbd_2063.

Proteomic databases

PRIDEQ3SH73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ98016; AAZ98016; Tbd_2063.
GeneID3672234.
KEGGtbd:Tbd_2063.
PATRIC23970301. VBIThiDen82923_2041.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycTDEN292415:GHWG-2109-MONOMER.
UniPathwayUPA00109; UER00181.
UPA00138.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI2_THIDA
AccessionPrimary (citable) accession number: Q3SH73
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways