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Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donorUniRule annotation
Active sitei391 – 3911UniRule annotation
Active sitei514 – 5141UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTDEN292415:GHWG-2109-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 2UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 2UniRule annotation
Short name:
PGI 2UniRule annotation
Phosphohexose isomerase 2UniRule annotation
Short name:
PHI 2UniRule annotation
Gene namesi
Name:pgi2UniRule annotation
Ordered Locus Names:Tbd_2063
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus
ProteomesiUP000008291: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Glucose-6-phosphate isomerase 2PRO_0000230940Add
BLAST

Proteomic databases

PRIDEiQ3SH73.

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_2063.

Structurei

3D structure databases

ProteinModelPortaliQ3SH73.
SMRiQ3SH73. Positions 9-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SH73-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTGDTRTSG LSTRPVHRLL QAHHSRMADV HMRELFDTDP QRFERFSLQV
60 70 80 90 100
GDLLLDYSKN RITDETMDLL VRMAEESDVA GWRERMFRGD KINTTENRAV
110 120 130 140 150
LHVALRNRSN RPVNVDGEDV MPKVNAVIER MGAFAEQVRG GVWRGYSGAL
160 170 180 190 200
ITDVVNIGIG GSDLGPQMVV QALKPYRHPR LKLHFISNVD GAHVKETLEA
210 220 230 240 250
LDPETTLFIV SSKTFTTQET MTNAHYARDW FLARAGDVAH VARHFVAVST
260 270 280 290 300
NRDAVTAFGI DAANMFEFWD WVGGRYSLWS AIGLSIVLAV GAERFLELLE
310 320 330 340 350
GAHEMDEHFR HAPLRQNMPV ILALLGIWYN NFFGAESHAI LPYDHYLRSL
360 370 380 390 400
PAYLEQADME SNGKSVDRDG RVVDYPTGQI IWGATGINGQ HAFYQLLHQG
410 420 430 440 450
TKMIPADFIV SITPHTELQE HHDILIANFL AQTEALMRGR TREETLEEMG
460 470 480 490 500
RSPGDPSVQH RVFEGNHPSN AILLKKLTPH TLGMLIALYE HKIFVEGVIW
510 520 530 540 550
NLNSYDQWGV ELGKQLAGRI LPELHADAPV AGHDASTNAL INHYRRMTQP

HPGL
Length:554
Mass (Da):62,388
Last modified:April 4, 2006 - v2
Checksum:i7A4EAAA90F8EE01B
GO

Sequence cautioni

The sequence AAZ98016.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA. Translation: AAZ98016.1. Different initiation.
RefSeqiYP_315821.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ98016; AAZ98016; Tbd_2063.
GeneIDi3672234.
KEGGitbd:Tbd_2063.
PATRICi23970301. VBIThiDen82923_2041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA. Translation: AAZ98016.1. Different initiation.
RefSeqiYP_315821.1. NC_007404.1.

3D structure databases

ProteinModelPortaliQ3SH73.
SMRiQ3SH73. Positions 9-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292415.Tbd_2063.

Proteomic databases

PRIDEiQ3SH73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ98016; AAZ98016; Tbd_2063.
GeneIDi3672234.
KEGGitbd:Tbd_2063.
PATRICi23970301. VBIThiDen82923_2041.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciTDEN292415:GHWG-2109-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
    Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
    J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25259.

Entry informationi

Entry nameiG6PI2_THIDA
AccessioniPrimary (citable) accession number: Q3SH73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: January 7, 2015
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.