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Protein

dCTP deaminase

Gene

dcd

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase (EC:3.5.4.13)
Alternative name(s):
Deoxycytidine triphosphate deaminase
Gene namesi
Name:dcd
Ordered Locus Names:Tbd_2107
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesThiobacillaceaeThiobacillus
Proteomesi
  • UP000008291 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000098261 – 188dCTP deaminaseAdd BLAST188

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_2107.

Structurei

3D structure databases

ProteinModelPortaliQ3SH29.
SMRiQ3SH29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228600.
KOiK01494.
OMAiGQLCLFR.
OrthoDBiPOG091H02A6.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR036157. dUTPase-like_sf.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SH29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKSDRWIR RMAAEHGMIE PFEAGQIKQA AGRSIVSYGT SSYGYDVRCA
60 70 80 90 100
SEFKLFTDIN TTIVDPKAFD PNSFVEVKGD SCIIPPNSFA LARTVEYFRI
110 120 130 140 150
PRSVLTICLG KSTYARCGII VNVTPLEPEW EGHVTLEFSN TTPLPARIYA
160 170 180
NEGVAQMLFL ESDEVCETSY RDRGGKYQGQ VGVTLPKI
Length:188
Mass (Da):20,917
Last modified:October 11, 2005 - v1
Checksum:i21836BF91A7D29CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000116 Genomic DNA. Translation: AAZ98060.1.
RefSeqiWP_011312619.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ98060; AAZ98060; Tbd_2107.
KEGGitbd:Tbd_2107.

Similar proteinsi

Entry informationi

Entry nameiDCD_THIDA
AccessioniPrimary (citable) accession number: Q3SH29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families