ID   GPH_THIDA               Reviewed;         227 AA.
AC   Q3SGR5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Phosphoglycolate phosphatase;
DE            Short=PGPase;
DE            Short=PGP;
DE            EC=3.1.3.18;
GN   OrderedLocusNames=Tbd_2229;
OS   Thiobacillus denitrificans (strain ATCC 25259).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Hydrogenophilales;
OC   Hydrogenophilaceae; Thiobacillus.
OX   NCBI_TaxID=292415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16452431; DOI=10.1128/JB.188.4.1473-1488.2006;
RA   Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA   Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT   "The genome sequence of the obligately chemolithoautotrophic,
RT   facultatively anaerobic bacterium Thiobacillus denitrificans.";
RL   J. Bacteriol. 188:1473-1488(2006).
CC   -!- FUNCTION: Specifically catalyzes the dephosphorylation of 2-
CC       phosphoglycolate. Is involved in the dissimilation of the
CC       intracellular 2-phosphoglycolate formed during the DNA repair of
CC       3'-phosphoglycolate ends, a major class of DNA lesions induced by
CC       oxidative stress (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2-phosphoglycolate + H(2)O = glycolate +
CC       phosphate.
CC   -!- PATHWAY: Organic acid metabolism; glycolic acid biosynthesis;
CC       glycolic acid from 2-phosphoglycolic acid: step 1/1.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       CbbY/cbbZ/gph/yieH family.
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DR   EMBL; CP000116; AAZ98182.1; -; Genomic_DNA.
DR   RefSeq; YP_315987.1; -.
DR   GeneID; 3673919; -.
DR   GenomeReviews; CP000116_GR; Tbd_2229.
DR   KEGG; tbd:Tbd_2229; -.
DR   NMPDR; fig|292415.3.peg.2160; -.
DR   HOGENOM; Q3SGR5; -.
DR   OMA; Q3SGR5; DSSNDAQ.
DR   BioCyc; TDEN292415:TBD_2229-MON; -.
DR   GO; GO:0008967; F:phosphoglycolate phosphatase activity; IEA:HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00495; -; 1.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   InterPro; IPR006439; HAD-SF_hydro_IA_v1.
DR   InterPro; IPR006402; HAD-SF_hydro_IA_v3.
DR   InterPro; IPR005833; Haloacid_DH/epoxide_hydro.
DR   InterPro; IPR006346; PGP_bact.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00413; HADHALOGNASE.
DR   TIGRFAMs; TIGR01549; HAD-SF-IA-v1; 1.
DR   TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
DR   TIGRFAMs; TIGR01449; PGP_bact; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Hydrolase.
FT   CHAIN         1    227       Phosphoglycolate phosphatase.
FT                                /FTId=PRO_0000238181.
FT   ACT_SITE     14     14       Nucleophile (By similarity).
SQ   SEQUENCE   227 AA;  24331 MW;  4A8399AA64E5334D CRC64;
     MKSFPLPIKA VVIDLDGTLL NTAPDLAHAA ELMMAELGRP CPSLETISTY IGNGVSRLVK
     RVLTGEMDAE PDPALFAQAI ASYQKHYGEH VSLHSRPFDG VVEGLQAFKA MGLHMACITN
     KAEQFTVPLL KGTGLYDYFE LILSGDTLPK RKPDPLPLLH ACEVFGVAPA ELLLIGDSLN
     DTQAARAAGC PVFCVPYGYN RGRPVTELDL DAVVPSLAEA ALMVTKA
//