Reviewed, UniProtKB/Swiss-Prot Q3SGR5 (GPH_THIDA)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

Tbd_2229

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Pathway	Organic acid metabolism; glycolic acid biosynthesis; glycolic acid from 2-phosphoglycolic acid: step 1/1. HAMAP MF_00495
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238181
Sites
	Active site	14	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SGR5-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 4A8399AA64E5334D	FASTA	227	24,331
	10 20 30 40 50 60 MKSFPLPIKA VVIDLDGTLL NTAPDLAHAA ELMMAELGRP CPSLETISTY IGNGVSRLVK 70 80 90 100 110 120 RVLTGEMDAE PDPALFAQAI ASYQKHYGEH VSLHSRPFDG VVEGLQAFKA MGLHMACITN 130 140 150 160 170 180 KAEQFTVPLL KGTGLYDYFE LILSGDTLPK RKPDPLPLLH ACEVFGVAPA ELLLIGDSLN 190 200 210 220 DTQAARAAGC PVFCVPYGYN RGRPVTELDL DAVVPSLAEA ALMVTKA

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000116 Genomic DNA. Translation: AAZ98182.1.
RefSeq	YP_315987.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3673919.
GenomeReviews	Gene locus Tbd_2229 in contig CP000116_GR.
KEGG	tbd:Tbd_2229.
NMPDR	fig|292415.3.peg.2160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3SGR5.
OMA	Q3SGR5. DSSNDAQ.
Enzyme and pathway databases
BioCyc	TDEN292415:TBD_2229-MON.
Family and domain databases
HAMAP	MF_00495. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_THIDA

Accession

Primary (citable) accession number: Q3SGR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)