Q3SGK8 (PHNN_THIDA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose 1,5-bisphosphate phosphokinase PhnN
EC=2.7.4.23

Alternative name(s):
Ribose 1,5-bisphosphokinase

Gene names

Name:	phnN
Ordered Locus Names:	Tbd_2289

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus › Thiobacillus denitrificans

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity. HAMAP-Rule MF_00836
Catalytic activity	ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00836
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3. HAMAP-Rule MF_00836
Sequence similarities	Belongs to the ribose 1,5-bisphosphokinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP organic phosphonate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribose 1,5-bisphosphate phosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Ribose 1,5-bisphosphate phosphokinase PhnN HAMAP-Rule MF_00836		PRO_0000412802
Regions
	Nucleotide binding	11 – 18	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3SGK8 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: D6A3A138FCD7980E	FASTA	190	21,260
	10 20 30 40 50 60 MSEGKLFYVI GPSGSGKDSL MRYGRERLAG DPGVVFAHRY ITRPVELHGE NHVALTEDEF 70 80 90 100 110 120 DARLATGLFA LHWDSHGLRY GIGREINLWL AKGCNVVLNG SREYLPEARR RYPGLTAILV 130 140 150 160 170 180 NVSPEVLAER LRARGRETED QISRRVARAK QFMHPEGRLE VIANDAELHV AGERLVQLLS 190 DADASKRAFA

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25259.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000116 Genomic DNA. Translation: AAZ98242.1.
RefSeq	YP_316047.1. NC_007404.1.
3D structure databases
ProteinModelPortal	Q3SGK8.
ModBase	Search...
Protein-protein interaction databases
STRING	292415.Tbd_2289.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ98242; AAZ98242; Tbd_2289.
GeneID	3673417.
KEGG	tbd:Tbd_2289.
PATRIC	23970767. VBIThiDen82923_2271.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3709.
HOGENOM	HOG000037637.
KO	K05774.
OMA	KVINVTA.
Enzyme and pathway databases
UniPathway	UPA00087; UER00175.
Family and domain databases
HAMAP	MF_00836. PhnN.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR012699. PhnN. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02322. phosphon_PhnN. 1 hit.
PROSITE	PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHNN_THIDA

Accession

Primary (citable) accession number: Q3SGK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program