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Q3SG58

- SYL_THIDA

UniProt

Q3SG58 - SYL_THIDA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTDEN292415:GHWG-2495-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tbd_2445
    OrganismiThiobacillus denitrificans (strain ATCC 25259)
    Taxonomic identifieri292415 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus
    ProteomesiUP000008291: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Leucine--tRNA ligasePRO_1000009458Add
    BLAST

    Proteomic databases

    PRIDEiQ3SG58.

    Interactioni

    Protein-protein interaction databases

    STRINGi292415.Tbd_2445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SG58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3SG58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKYLPSEI ERAGQARWTA DQTYRAADAS DRPKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLARYHALRG FNVMQPMGWD AFGLPAENAA IANGVPPAQW 100
    TYANIDHMRT QLQALGFAID WSRELATCKP DYYRWEQWLF TRLFEKGVIY 150
    KKMATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPM YFFRITQYAD 200
    ELLSGLDTLP GWPERVKTMQ ANWIGKSTGV RLAFPYELDG SQEKLWVFTT 250
    RADTLMGVTF VAVAAEHPLA ARAAENNPEL AAFVAECKQG SVAEADMATM 300
    EKKGMDTGFK VTHPLTGEEV PVWVGNYVLM SYGEGAVMAV PAHDERDFGF 350
    AKKYDLPIKQ VIGVDGETFS LDAWAEWYGD KTRGQCVNSG KYDRLGYEAA 400
    VDAIAADLAA KGLGEKKTQF RLRDWGISRQ RYWGCPIPII HCETCGDVPV 450
    PAEQLPVVLP EDVVPDGSGN PLNKRADFVN CTCPACGAPA RRETDTMDTF 500
    VESSWYYARY ACPDYADGML DARADQWLPV DQYIGGIEHA ILHLLYARFF 550
    HKLMRDEGLV ASDEPFANLL TQGMVVADTY YREDAGGKKT WFNPADVETK 600
    DGVATLRADG KPVVVGGTEK MSKSKNNGVD PQALIDQYGA DTARLFTMFA 650
    APPEQSLEWS DAGVEGAHRF LRRLWKTVYE HVQAGPVVTR AGGALPEPLK 700
    ALRRQLHQTI QKVGDDIERR KQFNTAIAAV MELMNALAKL DGMDADTRAV 750
    RQETLEAVAV LLAPIVPHVG EAIHAELRPG AAMRWPEVDA AALVQDEIEL 800
    MLQVNGKLRG QIRVAAGADK PAIEAAALAS EAVQKYLAGQ TPKKVVVVPG 850
    RLVNIVA 857
    Length:857
    Mass (Da):94,939
    Last modified:October 11, 2005 - v1
    Checksum:i792609177FB4A315
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000116 Genomic DNA. Translation: AAZ98398.1.
    RefSeqiYP_316203.1. NC_007404.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ98398; AAZ98398; Tbd_2445.
    GeneIDi3673955.
    KEGGitbd:Tbd_2445.
    PATRICi23971085. VBIThiDen82923_2429.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000116 Genomic DNA. Translation: AAZ98398.1 .
    RefSeqi YP_316203.1. NC_007404.1.

    3D structure databases

    ProteinModelPortali Q3SG58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292415.Tbd_2445.

    Proteomic databases

    PRIDEi Q3SG58.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ98398 ; AAZ98398 ; Tbd_2445 .
    GeneIDi 3673955.
    KEGGi tbd:Tbd_2445.
    PATRICi 23971085. VBIThiDen82923_2429.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TDEN292415:GHWG-2495-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
      Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
      J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25259.

    Entry informationi

    Entry nameiSYL_THIDA
    AccessioniPrimary (citable) accession number: Q3SG58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3