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Q3SG58

- SYL_THIDA

UniProt

Q3SG58 - SYL_THIDA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN292415:GHWG-2495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tbd_2445
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus
ProteomesiUP000008291: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligasePRO_1000009458Add
BLAST

Proteomic databases

PRIDEiQ3SG58.

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_2445.

Structurei

3D structure databases

ProteinModelPortaliQ3SG58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi620 – 6245"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3SG58 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEKYLPSEI ERAGQARWTA DQTYRAADAS DRPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLARYHALRG FNVMQPMGWD AFGLPAENAA IANGVPPAQW
110 120 130 140 150
TYANIDHMRT QLQALGFAID WSRELATCKP DYYRWEQWLF TRLFEKGVIY
160 170 180 190 200
KKMATVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPM YFFRITQYAD
210 220 230 240 250
ELLSGLDTLP GWPERVKTMQ ANWIGKSTGV RLAFPYELDG SQEKLWVFTT
260 270 280 290 300
RADTLMGVTF VAVAAEHPLA ARAAENNPEL AAFVAECKQG SVAEADMATM
310 320 330 340 350
EKKGMDTGFK VTHPLTGEEV PVWVGNYVLM SYGEGAVMAV PAHDERDFGF
360 370 380 390 400
AKKYDLPIKQ VIGVDGETFS LDAWAEWYGD KTRGQCVNSG KYDRLGYEAA
410 420 430 440 450
VDAIAADLAA KGLGEKKTQF RLRDWGISRQ RYWGCPIPII HCETCGDVPV
460 470 480 490 500
PAEQLPVVLP EDVVPDGSGN PLNKRADFVN CTCPACGAPA RRETDTMDTF
510 520 530 540 550
VESSWYYARY ACPDYADGML DARADQWLPV DQYIGGIEHA ILHLLYARFF
560 570 580 590 600
HKLMRDEGLV ASDEPFANLL TQGMVVADTY YREDAGGKKT WFNPADVETK
610 620 630 640 650
DGVATLRADG KPVVVGGTEK MSKSKNNGVD PQALIDQYGA DTARLFTMFA
660 670 680 690 700
APPEQSLEWS DAGVEGAHRF LRRLWKTVYE HVQAGPVVTR AGGALPEPLK
710 720 730 740 750
ALRRQLHQTI QKVGDDIERR KQFNTAIAAV MELMNALAKL DGMDADTRAV
760 770 780 790 800
RQETLEAVAV LLAPIVPHVG EAIHAELRPG AAMRWPEVDA AALVQDEIEL
810 820 830 840 850
MLQVNGKLRG QIRVAAGADK PAIEAAALAS EAVQKYLAGQ TPKKVVVVPG

RLVNIVA
Length:857
Mass (Da):94,939
Last modified:October 11, 2005 - v1
Checksum:i792609177FB4A315
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ98398.1.
RefSeqiWP_011312957.1. NC_007404.1.
YP_316203.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ98398; AAZ98398; Tbd_2445.
GeneIDi3673955.
KEGGitbd:Tbd_2445.
PATRICi23971085. VBIThiDen82923_2429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ98398.1 .
RefSeqi WP_011312957.1. NC_007404.1.
YP_316203.1. NC_007404.1.

3D structure databases

ProteinModelPortali Q3SG58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292415.Tbd_2445.

Proteomic databases

PRIDEi Q3SG58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ98398 ; AAZ98398 ; Tbd_2445 .
GeneIDi 3673955.
KEGGi tbd:Tbd_2445.
PATRICi 23971085. VBIThiDen82923_2429.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TDEN292415:GHWG-2495-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
    Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
    J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25259.

Entry informationi

Entry nameiSYL_THIDA
AccessioniPrimary (citable) accession number: Q3SG58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3