Q3SFZ9 (AROE_THIDA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Tbd_2504

Organism

Thiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]

Taxonomic identifier

292415 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Hydrogenophilales › Hydrogenophilaceae › Thiobacillus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325180
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3SFZ9 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: E19ACF4F21175D5F	FASTA	265	27,996
	10 20 30 40 50 60 MTDRYAVFGH PIAHSKSPQI HAAFARQTGQ DMCYEAILAP LEGFTESIAR FAAQGGRGAN 70 80 90 100 110 120 VTVPFKEEAF RLADRLTPRA ERAGAVNTLM FDADGILGDN TDGTGLVADL TGNLKRPLAT 130 140 150 160 170 180 RRILLVGAGG AARGVIAPLL EQAPAELVIA NRTVSRAEQL AELFDGRLRA CGFDALDTPF 190 200 210 220 230 240 DVVINATAAS LAGELPPLPP QVFGTGALAY DMMYGRDTPF LAFARAHGAD TADGLGMLVE 250 260 QAAEAFHLWR GVRPDTAPVI AALRA

References

[1]

"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans." Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P. J. Bacteriol. 188:1473-1488(2006) [PubMed: 16452431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25259.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000116 Genomic DNA. Translation: AAZ98457.1.
RefSeq	YP_316262.1. NC_007404.1.
3D structure databases
ProteinModelPortal	Q3SFZ9.
SMR	Q3SFZ9. Positions 3-265.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3SFZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3671823.
GenomeReviews	Gene locus Tbd_2504 in contig CP000116_GR.
KEGG	tbd:Tbd_2504.
NMPDR	fig|292415.3.peg.2577.
PATRIC	23971205. VBIThiDen82923_2489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	YERICAD.
PhylomeDB	Q3SFZ9.
Enzyme and pathway databases
BioCyc	TDEN292415:TBD_2504-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_THIDA

Accession

Primary (citable) accession number: Q3SFZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program