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Q3SFG5 (UPPP_THIDA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Tbd_2692
OrganismThiobacillus denitrificans (strain ATCC 25259) [Complete proteome] [HAMAP]
Taxonomic identifier292415 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000227645

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q3SFG5 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 06F19508B8483FFB

FASTA27629,964
        10         20         30         40         50         60 
MADLTQILHA LILGFVEGFT EFLPISSTGH LILAGQLLGF NGEKAKVFMI AIQLAAILAV 

        70         80         90        100        110        120 
VWEYRVRLRH VVSTVHTEPA SRRLVVNLMA GFLPAAVLGF LFYKEIKGYL FNPIVVASAL 

       130        140        150        160        170        180 
VIGGVLILWA ERRKHVVSTP TVDDLGWRRA LAVGFAQALA MVPGTSRSGA TIIGGLFLGL 

       190        200        210        220        230        240 
SRKAAAEFSF LLAIPTMFAA TAYDLYKNWQ LFDAGDIPLF AIGGVASFAS ALFAVRTLIK 

       250        260        270 
FVSRHDYTVF AWYRIVFGGV VLATAYSGLV DWGVTH 

« Hide

References

[1]"The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25259.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000116 Genomic DNA. Translation: AAZ98645.1.
RefSeqYP_316450.1. NC_007404.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292415.Tbd_2692.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ98645; AAZ98645; Tbd_2692.
GeneID3672421.
KEGGtbd:Tbd_2692.
PATRIC23971579. VBIThiDen82923_2676.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAPIVFDIY.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycTDEN292415:GHWG-2742-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_THIDA
AccessionPrimary (citable) accession number: Q3SFG5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 11, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families