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Q3SFG5

- UPPP_THIDA

UniProt

Q3SFG5 - UPPP_THIDA

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Tbd_2692
Organism
Thiobacillus denitrificans (strain ATCC 25259)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTDEN292415:GHWG-2742-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Tbd_2692
OrganismiThiobacillus denitrificans (strain ATCC 25259)
Taxonomic identifieri292415 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaHydrogenophilalesHydrogenophilaceaeThiobacillus
ProteomesiUP000008291: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Transmembranei185 – 20521Helical; Reviewed predictionAdd
BLAST
Transmembranei215 – 23521Helical; Reviewed predictionAdd
BLAST
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphataseUniRule annotationPRO_0000227645Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292415.Tbd_2692.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiPIVFDIY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3SFG5-1 [UniParc]FASTAAdd to Basket

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MADLTQILHA LILGFVEGFT EFLPISSTGH LILAGQLLGF NGEKAKVFMI    50
AIQLAAILAV VWEYRVRLRH VVSTVHTEPA SRRLVVNLMA GFLPAAVLGF 100
LFYKEIKGYL FNPIVVASAL VIGGVLILWA ERRKHVVSTP TVDDLGWRRA 150
LAVGFAQALA MVPGTSRSGA TIIGGLFLGL SRKAAAEFSF LLAIPTMFAA 200
TAYDLYKNWQ LFDAGDIPLF AIGGVASFAS ALFAVRTLIK FVSRHDYTVF 250
AWYRIVFGGV VLATAYSGLV DWGVTH 276
Length:276
Mass (Da):29,964
Last modified:October 11, 2005 - v1
Checksum:i06F19508B8483FFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ98645.1.
RefSeqiWP_011313204.1. NC_007404.1.
YP_316450.1. NC_007404.1.

Genome annotation databases

EnsemblBacteriaiAAZ98645; AAZ98645; Tbd_2692.
GeneIDi3672421.
KEGGitbd:Tbd_2692.
PATRICi23971579. VBIThiDen82923_2676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000116 Genomic DNA. Translation: AAZ98645.1 .
RefSeqi WP_011313204.1. NC_007404.1.
YP_316450.1. NC_007404.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292415.Tbd_2692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ98645 ; AAZ98645 ; Tbd_2692 .
GeneIDi 3672421.
KEGGi tbd:Tbd_2692.
PATRICi 23971579. VBIThiDen82923_2676.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi PIVFDIY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci TDEN292415:GHWG-2742-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans."
    Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W., Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.
    J. Bacteriol. 188:1473-1488(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25259.

Entry informationi

Entry nameiUPPP_THIDA
AccessioniPrimary (citable) accession number: Q3SFG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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