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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

Gene

PIGY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.1 Publication

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

  • GPI anchor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi2.4.1.198. 2681.
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class Y protein
Short name:
PIG-Y
Gene namesi
Name:PIGY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28213. PIGY.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence analysis
Transmembranei4 – 2623HelicalSequence analysisAdd
BLAST
Topological domaini27 – 4418LumenalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Topological domaini66 – 716CytoplasmicSequence analysis

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: MGI
  • glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171Phosphatidylinositol N-acetylglucosaminyltransferase subunit YPRO_0000246311Add
BLAST

Proteomic databases

PaxDbiQ3MUY2.

PTM databases

iPTMnetiQ3MUY2.

Expressioni

Gene expression databases

CleanExiHS_PIGY.

Organism-specific databases

HPAiHPA059018.

Interactioni

Subunit structurei

Interacts with the GPI-GnT complex composed of PIGA, PIGC, PIGH, PIGP, PIGQ and DPM2. Interacts directly with PIGA. Does not interact with Ras proteins.1 Publication

Protein-protein interaction databases

BioGridi124417. 1 interaction.
IntActiQ3MUY2. 1 interaction.
STRINGi9606.ENSP00000432688.

Structurei

3D structure databases

ProteinModelPortaliQ3MUY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JDU7. Eukaryota.
ENOG4111BVT. LUCA.
GeneTreeiENSGT00610000087446.
HOVERGENiHBG082140.
InParanoidiQ3MUY2.
KOiK11001.
OMAiFPEGCTS.
OrthoDBiEOG76MKC4.

Family and domain databases

InterProiIPR029164. PIG-Y.
[Graphical view]
PfamiPF15159. PIG-Y. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MUY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLSLPTLTV LIPLVSLAGL FYSASVEENF PQGCTSTASL CFYSLLLPIT
60 70
IPVYVFFHLW TWMGIKLFRH N
Length:71
Mass (Da):8,058
Last modified:October 25, 2005 - v1
Checksum:i143975D8CCECED34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB206972 mRNA. Translation: BAE44507.1.
BC007876 mRNA. Translation: AAH07876.2.
CCDSiCCDS54778.1.
RefSeqiNP_001036081.1. NM_001042616.2.
UniGeneiHs.26136.
Hs.743393.

Genome annotation databases

EnsembliENST00000527353; ENSP00000432688; ENSG00000255072.
GeneIDi84992.
KEGGihsa:84992.
UCSCiuc062ydg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB206972 mRNA. Translation: BAE44507.1.
BC007876 mRNA. Translation: AAH07876.2.
CCDSiCCDS54778.1.
RefSeqiNP_001036081.1. NM_001042616.2.
UniGeneiHs.26136.
Hs.743393.

3D structure databases

ProteinModelPortaliQ3MUY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124417. 1 interaction.
IntActiQ3MUY2. 1 interaction.
STRINGi9606.ENSP00000432688.

PTM databases

iPTMnetiQ3MUY2.

Proteomic databases

PaxDbiQ3MUY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527353; ENSP00000432688; ENSG00000255072.
GeneIDi84992.
KEGGihsa:84992.
UCSCiuc062ydg.1. human.

Organism-specific databases

CTDi84992.
GeneCardsiPIGY.
HGNCiHGNC:28213. PIGY.
HPAiHPA059018.
MIMi610662. gene.
neXtProtiNX_Q3MUY2.
PharmGKBiPA143485576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDU7. Eukaryota.
ENOG4111BVT. LUCA.
GeneTreeiENSGT00610000087446.
HOVERGENiHBG082140.
InParanoidiQ3MUY2.
KOiK11001.
OMAiFPEGCTS.
OrthoDBiEOG76MKC4.

Enzyme and pathway databases

UniPathwayiUPA00196.
BRENDAi2.4.1.198. 2681.

Miscellaneous databases

ChiTaRSiPIGY. human.
GenomeRNAii84992.
PROiQ3MUY2.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PIGY.

Family and domain databases

InterProiIPR029164. PIG-Y.
[Graphical view]
PfamiPF15159. PIG-Y. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component."
    Murakami Y., Siripanyaphinyo U., Hong Y., Tashima Y., Maeda Y., Kinoshita T.
    Mol. Biol. Cell 16:5236-5246(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-10, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH PIGA.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiPIGY_HUMAN
AccessioniPrimary (citable) accession number: Q3MUY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2005
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.