ID   Q3MSN4_HUMAN            Unreviewed;       145 AA.
AC   Q3MSN4;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   SubName: Full=Nuclear receptor subfamily 3 group C member 1 {ECO:0000313|Ensembl:ENSP00000420856.1};
DE   SubName: Full=Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor) {ECO:0000313|EMBL:CAI46894.1};
DE   Flags: Fragment;
GN   Name=NR3C1 {ECO:0000313|EMBL:CAI46894.1,
GN   ECO:0000313|Ensembl:ENSP00000420856.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAI46894.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420856.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|EMBL:CAI46894.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Hippocampus {ECO:0000313|EMBL:CAI46893.1};
RX   PubMed=16216909; DOI=10.1677/jme.1.01822;
RA   Turner J.D., Muller C.P.;
RT   "Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated
RT   region: identification, and tissue distribution of multiple new human exon
RT   1.";
RL   J. Mol. Endocrinol. 35:283-292(2005).
RN   [3] {ECO:0007829|PubMed:16964243}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16964243; DOI=10.1038/nbt1240;
RA   Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT   "A probability-based approach for high-throughput protein phosphorylation
RT   analysis and site localization.";
RL   Nat. Biotechnol. 24:1285-1292(2006).
RN   [4] {ECO:0007829|PubMed:18691976}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA   Greff Z., Keri G., Stemmann O., Mann M.;
RT   "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT   kinome across the cell cycle.";
RL   Mol. Cell 31:438-448(2008).
RN   [5] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6] {ECO:0007829|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [7] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [8] {ECO:0007829|PubMed:22814378}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [9] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [10] {ECO:0000313|Ensembl:ENSP00000420856.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC004782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ877166; CAI46893.1; -; mRNA.
DR   EMBL; AJ877167; CAI46894.1; -; mRNA.
DR   EMBL; AJ877168; CAI46895.1; -; mRNA.
DR   EMBL; AJ877169; CAI46896.1; -; mRNA.
DR   EMBL; AJ877171; CAI46898.1; -; mRNA.
DR   EMBL; AJ877172; CAI46899.1; -; mRNA.
DR   EMBL; AJ888004; CAI59612.1; -; mRNA.
DR   IntAct; Q3MSN4; 2.
DR   ProteomicsDB; 61810; -.
DR   Antibodypedia; 1329; 1586 antibodies from 44 providers.
DR   Ensembl; ENST00000502892.5; ENSP00000420856.1; ENSG00000113580.15.
DR   Ensembl; ENST00000508760.5; ENSP00000425313.1; ENSG00000113580.15.
DR   Ensembl; ENST00000510170.5; ENSP00000424747.1; ENSG00000113580.15.
DR   Ensembl; ENST00000514699.1; ENSP00000426478.1; ENSG00000113580.15.
DR   UCSC; uc063igc.1; human.
DR   HGNC; HGNC:7978; NR3C1.
DR   VEuPathDB; HostDB:ENSG00000113580; -.
DR   GeneTree; ENSGT00940000156385; -.
DR   OMA; GLYMGDT; -.
DR   ChiTaRS; NR3C1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113580; Expressed in endothelial cell and 212 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004883; F:nuclear glucocorticoid receptor activity; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR001409; Glcrtcd_rcpt.
DR   Pfam; PF02155; GCR; 1.
DR   PRINTS; PR00528; GLCORTICOIDR.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q3MSN4,
KW   ECO:0007829|MaxQB:Q3MSN4}; Receptor {ECO:0000313|EMBL:CAI46894.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         145
FT                   /evidence="ECO:0000313|EMBL:CAI46894.1"
SQ   SEQUENCE   145 AA;  15399 MW;  E0EEC5AF8CA45F89 CRC64;
     MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR
     LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK
     LLEESIANLN RSTSVPENPK SSAST
//