Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3MSN4

- Q3MSN4_HUMAN

UniProt

Q3MSN4 - Q3MSN4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Glucocorticoid receptor

Gene

NR3C1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. glucocorticoid receptor activity Source: Ensembl
  2. sequence-specific DNA binding Source: Ensembl
  3. steroid binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. glucocorticoid metabolic process Source: Ensembl
  3. mammary gland duct morphogenesis Source: Ensembl
  4. negative regulation of glucocorticoid mediated signaling pathway Source: Ensembl
  5. positive regulation of neuron apoptotic process Source: Ensembl
  6. regulation of glucocorticoid biosynthetic process Source: Ensembl
  7. regulation of gluconeogenesis Source: Ensembl
  8. regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Submitted name:
Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)Imported
Gene namesi
Name:NR3C1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:7978. NR3C1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Ensembl
  3. membrane Source: Ensembl
  4. nucleus Source: HPA
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Family and domain databases

InterProiIPR001409. Glcrtcd_rcpt.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.

Sequencei

Sequence statusi: Fragment.

Q3MSN4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV
60 70 80 90 100
ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN
110 120 130 140
DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSAST
Length:145
Mass (Da):15,399
Last modified:October 25, 2005 - v1
Checksum:iE0EEC5AF8CA45F89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei145 – 1451Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004782 Genomic DNA. No translation available.
AC091925 Genomic DNA. No translation available.
AJ877166 mRNA. Translation: CAI46893.1.
AJ877167 mRNA. Translation: CAI46894.1.
AJ877168 mRNA. Translation: CAI46895.1.
AJ877169 mRNA. Translation: CAI46896.1.
AJ877171 mRNA. Translation: CAI46898.1.
AJ877172 mRNA. Translation: CAI46899.1.
AJ888004 mRNA. Translation: CAI59612.1.
UniGeneiHs.122926.

Genome annotation databases

EnsembliENST00000502892; ENSP00000420856; ENSG00000113580.
ENST00000508760; ENSP00000425313; ENSG00000113580.
ENST00000510170; ENSP00000424747; ENSG00000113580.
ENST00000514699; ENSP00000426478; ENSG00000113580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004782 Genomic DNA. No translation available.
AC091925 Genomic DNA. No translation available.
AJ877166 mRNA. Translation: CAI46893.1 .
AJ877167 mRNA. Translation: CAI46894.1 .
AJ877168 mRNA. Translation: CAI46895.1 .
AJ877169 mRNA. Translation: CAI46896.1 .
AJ877171 mRNA. Translation: CAI46898.1 .
AJ877172 mRNA. Translation: CAI46899.1 .
AJ888004 mRNA. Translation: CAI59612.1 .
UniGenei Hs.122926.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000502892 ; ENSP00000420856 ; ENSG00000113580 .
ENST00000508760 ; ENSP00000425313 ; ENSG00000113580 .
ENST00000510170 ; ENSP00000424747 ; ENSG00000113580 .
ENST00000514699 ; ENSP00000426478 ; ENSG00000113580 .

Organism-specific databases

HGNCi HGNC:7978. NR3C1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118887.

Miscellaneous databases

ChiTaRSi NR3C1. human.

Family and domain databases

InterProi IPR001409. Glcrtcd_rcpt.
[Graphical view ]
Pfami PF02155. GCR. 1 hit.
[Graphical view ]
PRINTSi PR00528. GLCORTICOIDR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1."
    Turner J.D., Muller C.P.
    J. Mol. Endocrinol. 35:283-292(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ3MSN4_HUMAN
AccessioniPrimary (citable) accession number: Q3MSN4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3