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Q3MSN4

- Q3MSN4_HUMAN

UniProt

Q3MSN4 - Q3MSN4_HUMAN

Protein
Submitted name:

Glucocorticoid receptor

Gene

NR3C1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. glucocorticoid receptor activity Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. steroid binding Source: InterPro

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. glucocorticoid metabolic process Source: Ensembl
    3. mammary gland duct morphogenesis Source: Ensembl
    4. positive regulation of neuron apoptotic process Source: Ensembl
    5. regulation of glucocorticoid biosynthetic process Source: Ensembl
    6. regulation of gluconeogenesis Source: Ensembl
    7. regulation of transcription, DNA-templated Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glucocorticoid receptorImported
    Submitted name:
    Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)Imported
    Gene namesi
    Name:NR3C1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:7978. NR3C1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Ensembl
    3. membrane Source: Ensembl
    4. nucleus Source: HPA

    Family & Domainsi

    Family and domain databases

    InterProiIPR001409. Glcrtcd_rcpt.
    [Graphical view]
    PfamiPF02155. GCR. 1 hit.
    [Graphical view]
    PRINTSiPR00528. GLCORTICOIDR.

    Sequencei

    Sequence statusi: Fragment.

    Q3MSN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV    50
    ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN 100
    DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSAST 145
    Length:145
    Mass (Da):15,399
    Last modified:October 25, 2005 - v1
    Checksum:iE0EEC5AF8CA45F89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei145 – 1451Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004782 Genomic DNA. No translation available.
    AC091925 Genomic DNA. No translation available.
    AJ877166 mRNA. Translation: CAI46893.1.
    AJ877167 mRNA. Translation: CAI46894.1.
    AJ877168 mRNA. Translation: CAI46895.1.
    AJ877169 mRNA. Translation: CAI46896.1.
    AJ877171 mRNA. Translation: CAI46898.1.
    AJ877172 mRNA. Translation: CAI46899.1.
    AJ888004 mRNA. Translation: CAI59612.1.
    UniGeneiHs.122926.

    Genome annotation databases

    EnsembliENST00000502892; ENSP00000420856; ENSG00000113580.
    ENST00000508760; ENSP00000425313; ENSG00000113580.
    ENST00000510170; ENSP00000424747; ENSG00000113580.
    ENST00000514699; ENSP00000426478; ENSG00000113580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004782 Genomic DNA. No translation available.
    AC091925 Genomic DNA. No translation available.
    AJ877166 mRNA. Translation: CAI46893.1 .
    AJ877167 mRNA. Translation: CAI46894.1 .
    AJ877168 mRNA. Translation: CAI46895.1 .
    AJ877169 mRNA. Translation: CAI46896.1 .
    AJ877171 mRNA. Translation: CAI46898.1 .
    AJ877172 mRNA. Translation: CAI46899.1 .
    AJ888004 mRNA. Translation: CAI59612.1 .
    UniGenei Hs.122926.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000502892 ; ENSP00000420856 ; ENSG00000113580 .
    ENST00000508760 ; ENSP00000425313 ; ENSG00000113580 .
    ENST00000510170 ; ENSP00000424747 ; ENSG00000113580 .
    ENST00000514699 ; ENSP00000426478 ; ENSG00000113580 .

    Organism-specific databases

    HGNCi HGNC:7978. NR3C1.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi NR3C1. human.

    Family and domain databases

    InterProi IPR001409. Glcrtcd_rcpt.
    [Graphical view ]
    Pfami PF02155. GCR. 1 hit.
    [Graphical view ]
    PRINTSi PR00528. GLCORTICOIDR.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1."
      Turner J.D., Muller C.P.
      J. Mol. Endocrinol. 35:283-292(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HippocampusImported.
    3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ3MSN4_HUMAN
    AccessioniPrimary (citable) accession number: Q3MSN4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3