ID   SSDH_PANPA              Reviewed;         535 AA.
AC   Q3MSM4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial;
DE            EC=1.2.1.24;
DE   AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 5 member A1;
DE   Flags: Precursor;
GN   Name=ALDH5A1;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blasi P., Palmerio F., Aiello A., Rocchi M., Malaspina P.,
RA   Novelletto A.;
RT   "Human succinic semialdehyde dehydrogenase variation in higher
RT   primates: intra and inter specific data.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(+) + H(2)O =
CC       succinate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AJ891037; CAI69937.1; -; mRNA.
DR   HOVERGEN; Q3MSM4; -.
DR   BRENDA; 1.2.1.24; 289054.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005625; C:soluble fraction; ISS:UniProtKB.
DR   GO; GO:0004777; F:succinate-semialdehyde dehydrogenase activity; ISS:UniProtKB.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; ISS:UniProtKB.
DR   GO; GO:0055114; P:oxidation reduction; ISS:UniProtKB.
DR   GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR010102; Succ_semiAld_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01780; SSADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; NAD; Oxidoreductase; Transit peptide.
FT   TRANSIT       1     47       Mitochondrion (Potential).
FT   CHAIN        48    535       Succinate-semialdehyde dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000042902.
FT   NP_BIND     284    289       NADP (By similarity).
FT   ACT_SITE    306    306       Proton acceptor (By similarity).
FT   ACT_SITE    340    340       Nucleophile (By similarity).
FT   SITE        205    205       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   535 AA;  57188 MW;  C78625F5251EFBC2 CRC64;
     MATCIWLRSC GARRLGWTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG LAGLSAALLR
     TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC CWREVSAKER
     SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY
     TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL
     AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV
     KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF
     AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF
     EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR
     VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
//