Q3MS96 (Q3MS96_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2 EMBL CAJ19682.1

Gene names

Name:

BTK kinase deficient isoform 2 EMBL CAJ19682.1

Organism

Homo sapiens (Human) EMBL CAJ19682.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	319 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS008266
Gene Ontology (GO)
Biological_process	I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara cell maturation Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic vesicle Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAJ19682.1

Sequences

	Sequence		Length	Mass (Da)
	Q3MS96 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 85C37271DCF3C64A	FASTA	319	36,871
	10 20 30 40 50 60 VIRHYVVCST PQSQYYLAEK HLFSTIPELI NYHQHNSAGL ISRLKYPVSQ QNKNAPSTAG 70 80 90 100 110 120 LGYGSWEIDP KDLTFLKELG TGQFGVVKYG KWRGQYDVAI KMIKEGSMSE DEFIEEAKVM 130 140 150 160 170 180 MNLSHEKLVQ LYGVCTKQRP IFIITEYMAN GCLLNYLREM RHRFQTQQLL EMCKDVCEAM 190 200 210 220 230 240 EYLESKQFLH RDLAARNCLV NDQGVVKVSD FGLSRYVLDD EYTSSVGSKF PVRWSPPEVL 250 260 270 280 290 300 MYSKFSSKSD IWAFGVLMWE IYSLGKMPYE RFTNSETAEH IAQGLRLYRP HLASEKKADE 310 RPTFKILLSN ILDVMDEES

References

[1]	"Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells." Feldhahn N., Rio P., Ndikung B.B.S., Liedtke S., Sprangers M., Klein F., Wernet P., Jumaa H., Hofmann W.K., Hanenberg H., Rowley J.D., Mueschen M. Proc. Natl. Acad. Sci. U.S.A. 102:13266-13271(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM051276 mRNA. Translation: CAJ19682.1.
IPI	IPI00029132.
UniGene	Hs.159494.
3D structure databases
ProteinModelPortal	Q3MS96.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3MS96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010nnm.2. human.
Phylogenomic databases
HOVERGEN	HBG008761.
Gene expression databases
ArrayExpress	Q3MS96.
Bgee	Q3MS96.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3MS96_HUMAN

Accession

Primary (citable) accession number: Q3MS96

Entry history

Integrated into UniProtKB/TrEMBL:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	March 6, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.