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Protein

Protein BEX1

Gene

Bex1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.1 Publication

GO - Biological processi

  • negative regulation of neuron differentiation Source: MGI
  • neurotrophin TRK receptor signaling pathway Source: MGI
  • positive regulation of neuroblast proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1 homolog
EG2RVC
Gene namesi
Name:Bex1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1564643. Bex1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi19 – 191K → E: Does not affect subcellular location. 1 Publication
Mutagenesisi45 – 451K → E: Does not affect subcellular location. 1 Publication
Mutagenesisi53 – 553RRR → AAA: Abolishes nuclear localization. 1 Publication
Mutagenesisi105 – 1051S → A: Abolishes phosphorylation, leading to degradation by the proteasome. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Protein BEX1PRO_0000229775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Phosphoserine; by PKB/AKT11 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome.1 Publication
Ubiquitinated (Probable). Degraded by the proteasome (By similarity).By similarityCurated

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ3MKQ2.

PTM databases

iPTMnetiQ3MKQ2.
PhosphoSiteiQ3MKQ2.

Expressioni

Tissue specificityi

Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.1 Publication

Developmental stagei

Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with OMP (By similarity). Interacts with neurotrophin receptor p75NTR/NGFR.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NgfrP071744EBI-8089575,EBI-1038810

Protein-protein interaction databases

BioGridi272932. 1 interaction.
IntActiQ3MKQ2. 1 interaction.
MINTiMINT-1955167.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ3MKQ2.
PhylomeDBiQ3MKQ2.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MKQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDQGAKN LNMENDHQKK EEKEEKPQDT IKREPVVAPT FEAGKNCAPR
60 70 80 90 100
GGRRRFRVRQ PIAHYRWDLM HRVGEPQGRM REENVQRFGE DMRQLMEKLR
110 120
ERQLSHSLRA VSTDPPHHDH HDEFCLMP
Length:128
Mass (Da):15,248
Last modified:April 4, 2006 - v2
Checksum:i13F8CCF5021C9D49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631A → S in AAX40672 (PubMed:15958283).Curated
Sequence conflicti76 – 761P → A in AAX40672 (PubMed:15958283).Curated
Sequence conflicti82 – 821E → D in AAX40672 (PubMed:15958283).Curated
Sequence conflicti94 – 941Q → H in AAX40672 (PubMed:15958283).Curated
Sequence conflicti97 – 971E → G in AAX40672 (PubMed:15958283).Curated
Sequence conflicti121 – 1211H → N in AAX40672 (PubMed:15958283).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208292 mRNA. Translation: AAP81280.1.
AY833554 mRNA. Translation: AAX40672.1.
RefSeqiNP_001032442.1. NM_001037365.1.
UniGeneiRn.9190.

Genome annotation databases

GeneIDi501625.
KEGGirno:501625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208292 mRNA. Translation: AAP81280.1.
AY833554 mRNA. Translation: AAX40672.1.
RefSeqiNP_001032442.1. NM_001037365.1.
UniGeneiRn.9190.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi272932. 1 interaction.
IntActiQ3MKQ2. 1 interaction.
MINTiMINT-1955167.

PTM databases

iPTMnetiQ3MKQ2.
PhosphoSiteiQ3MKQ2.

Proteomic databases

PRIDEiQ3MKQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi501625.
KEGGirno:501625.

Organism-specific databases

CTDi55859.
RGDi1564643. Bex1.

Phylogenomic databases

HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ3MKQ2.
PhylomeDBiQ3MKQ2.
TreeFamiTF337909.

Miscellaneous databases

PROiQ3MKQ2.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBEX1_RAT
AccessioniPrimary (citable) accession number: Q3MKQ2
Secondary accession number(s): Q6XUZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.