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Protein

Protein BEX1

Gene

Bex1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.1 Publication

GO - Biological processi

  • negative regulation of neuron differentiation Source: MGI
  • neurotrophin TRK receptor signaling pathway Source: MGI
  • positive regulation of neuroblast proliferation Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1 homolog
EG2RVC
Gene namesi
Name:Bex1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1564643. Bex1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19K → E: Does not affect subcellular location. 1 Publication1
Mutagenesisi45K → E: Does not affect subcellular location. 1 Publication1
Mutagenesisi53 – 55RRR → AAA: Abolishes nuclear localization. 1 Publication3
Mutagenesisi105S → A: Abolishes phosphorylation, leading to degradation by the proteasome. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297751 – 128Protein BEX1Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50Omega-N-methylarginineBy similarity1
Modified residuei105Phosphoserine; by PKB/AKT11 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome.1 Publication
Ubiquitinated (Probable). Degraded by the proteasome (By similarity).By similarityCurated

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ3MKQ2.

PTM databases

iPTMnetiQ3MKQ2.
PhosphoSitePlusiQ3MKQ2.

Expressioni

Tissue specificityi

Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.1 Publication

Developmental stagei

Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with OMP (By similarity). Interacts with neurotrophin receptor p75NTR/NGFR.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NgfrP071744EBI-8089575,EBI-1038810

Protein-protein interaction databases

BioGridi272932. 1 interactor.
IntActiQ3MKQ2. 1 interactor.
MINTiMINT-1955167.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ3MKQ2.
PhylomeDBiQ3MKQ2.
TreeFamiTF337909.

Family and domain databases

InterProiView protein in InterPro
IPR007623. BEX.
IPR021156. TF_A-like/BEX.
PfamiView protein in Pfam
PF04538. BEX. 1 hit.
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MKQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDQGAKN LNMENDHQKK EEKEEKPQDT IKREPVVAPT FEAGKNCAPR
60 70 80 90 100
GGRRRFRVRQ PIAHYRWDLM HRVGEPQGRM REENVQRFGE DMRQLMEKLR
110 120
ERQLSHSLRA VSTDPPHHDH HDEFCLMP
Length:128
Mass (Da):15,248
Last modified:April 4, 2006 - v2
Checksum:i13F8CCF5021C9D49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63A → S in AAX40672 (PubMed:15958283).Curated1
Sequence conflicti76P → A in AAX40672 (PubMed:15958283).Curated1
Sequence conflicti82E → D in AAX40672 (PubMed:15958283).Curated1
Sequence conflicti94Q → H in AAX40672 (PubMed:15958283).Curated1
Sequence conflicti97E → G in AAX40672 (PubMed:15958283).Curated1
Sequence conflicti121H → N in AAX40672 (PubMed:15958283).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208292 mRNA. Translation: AAP81280.1.
AY833554 mRNA. Translation: AAX40672.1.
RefSeqiNP_001032442.1. NM_001037365.1.
UniGeneiRn.9190.

Genome annotation databases

GeneIDi501625.
KEGGirno:501625.

Similar proteinsi

Entry informationi

Entry nameiBEX1_RAT
AccessioniPrimary (citable) accession number: Q3MKQ2
Secondary accession number(s): Q6XUZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: August 30, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families