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Protein

Protein BEX2

Gene

Bex2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX2
Alternative name(s):
Brain-expressed X-linked protein 2 homolog
Gene namesi
Name:Bex2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1564466. Bex2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi103 – 1031R → L: Induces a redistribution from both the nucleus and cytoplasm to only the cytoplasm. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Protein BEX2PRO_0000229779Add
BLAST

Proteomic databases

PaxDbiQ3MKQ1.

PTM databases

PhosphoSiteiQ3MKQ1.

Expressioni

Gene expression databases

GenevisibleiQ3MKQ1. RN.

Interactioni

Subunit structurei

Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041688.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ3MKQ1.
OMAiEAGEYCV.
OrthoDBiEOG7XPZ7S.
PhylomeDBiQ3MKQ1.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MKQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVEQGVK NLNMENDHQE KEEKEEKPQD ANKREPVVAL PFEAGEYYVP
60 70 80 90 100
RGSRRRFRVR QPIAHYRWDL MHRVGEPQGR MREENVQRFG EDMRQLMEKL
110 120
RERQLSHSLR AVSTDPPHHD HHDEFCLMP
Length:129
Mass (Da):15,541
Last modified:October 25, 2005 - v1
Checksum:iBB8AF95C1058A4A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833555 mRNA. Translation: AAX40673.1.
RefSeqiNP_001070903.1. NM_001077435.1.
UniGeneiRn.33240.

Genome annotation databases

EnsembliENSRNOT00000042126; ENSRNOP00000041688; ENSRNOG00000032729.
GeneIDi363498.
KEGGirno:363498.
UCSCiRGD:1564466. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833555 mRNA. Translation: AAX40673.1.
RefSeqiNP_001070903.1. NM_001077435.1.
UniGeneiRn.33240.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041688.

PTM databases

PhosphoSiteiQ3MKQ1.

Proteomic databases

PaxDbiQ3MKQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042126; ENSRNOP00000041688; ENSRNOG00000032729.
GeneIDi363498.
KEGGirno:363498.
UCSCiRGD:1564466. rat.

Organism-specific databases

CTDi84707.
RGDi1564466. Bex2.

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ3MKQ1.
OMAiEAGEYCV.
OrthoDBiEOG7XPZ7S.
PhylomeDBiQ3MKQ1.
TreeFamiTF337909.

Miscellaneous databases

PROiQ3MKQ1.

Gene expression databases

GenevisibleiQ3MKQ1. RN.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the Bex gene family in humans, mice, and rats."
    Alvarez E., Zhou W., Witta S.E., Freed C.R.
    Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-103.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiBEX2_RAT
AccessioniPrimary (citable) accession number: Q3MKQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.