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Protein

Protein BEX2

Gene

Bex2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX2
Alternative name(s):
Brain-expressed X-linked protein 2 homolog
Gene namesi
Name:Bex2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1564466 Bex2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103R → L: Induces a redistribution from both the nucleus and cytoplasm to only the cytoplasm. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297791 – 129Protein BEX2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ3MKQ1

PTM databases

PhosphoSitePlusiQ3MKQ1

Expressioni

Gene expression databases

BgeeiENSRNOG00000032729
GenevisibleiQ3MKQ1 RN

Interactioni

Subunit structurei

Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041688

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY Eukaryota
ENOG4111DNW LUCA
GeneTreeiENSGT00810000125540
HOGENOMiHOG000236300
HOVERGENiHBG080240
InParanoidiQ3MKQ1
OMAiEAGEYCV
OrthoDBiEOG091G0ZN3
PhylomeDBiQ3MKQ1
TreeFamiTF337909

Family and domain databases

InterProiView protein in InterPro
IPR007623 BEX
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit
PIRSFiPIRSF008633 BEX, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MKQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVEQGVK NLNMENDHQE KEEKEEKPQD ANKREPVVAL PFEAGEYYVP
60 70 80 90 100
RGSRRRFRVR QPIAHYRWDL MHRVGEPQGR MREENVQRFG EDMRQLMEKL
110 120
RERQLSHSLR AVSTDPPHHD HHDEFCLMP
Length:129
Mass (Da):15,541
Last modified:October 25, 2005 - v1
Checksum:iBB8AF95C1058A4A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY833555 mRNA Translation: AAX40673.1
RefSeqiNP_001070903.1, NM_001077435.1
UniGeneiRn.33240

Genome annotation databases

EnsembliENSRNOT00000042126; ENSRNOP00000041688; ENSRNOG00000032729
GeneIDi363498
KEGGirno:363498
UCSCiRGD:1564466 rat

Similar proteinsi

Entry informationi

Entry nameiBEX2_RAT
AccessioniPrimary (citable) accession number: Q3MKQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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