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Protein

Zinc finger and SCAN domain-containing protein 23

Gene

ZSCAN23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 23
Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453
Gene namesi
Name:ZSCAN23
Synonyms:ZNF390, ZNF453
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187987.9.
HGNCiHGNC:21193. ZSCAN23.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187987.
PharmGKBiPA162410995.

Polymorphism and mutation databases

BioMutaiZSCAN23.
DMDMi121949042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804111 – 389Zinc finger and SCAN domain-containing protein 23Add BLAST389

Proteomic databases

EPDiQ3MJ62.
MaxQBiQ3MJ62.
PaxDbiQ3MJ62.
PeptideAtlasiQ3MJ62.
PRIDEiQ3MJ62.

PTM databases

iPTMnetiQ3MJ62.
PhosphoSitePlusiQ3MJ62.

Expressioni

Gene expression databases

BgeeiENSG00000187987.
CleanExiHS_ZSCAN23.
ExpressionAtlasiQ3MJ62. baseline and differential.
GenevisibleiQ3MJ62. HS.

Organism-specific databases

HPAiHPA035959.
HPA035960.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128813. 3 interactors.
IntActiQ3MJ62. 18 interactors.
STRINGi9606.ENSP00000289788.

Structurei

3D structure databases

ProteinModelPortaliQ3MJ62.
SMRiQ3MJ62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 130SCAN boxPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 27Poly-Glu5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ3MJ62.
KOiK09230.
OMAiTCDHEGR.
OrthoDBiEOG091G09O3.
PhylomeDBiQ3MJ62.
TreeFamiTF338304.

Family and domain databases

InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Q3MJ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR
60 70 80 90 100
FRQFCYQESP GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL
110 120 130 140 150
PEELQAWVRQ HRPVSGEEAV TVLEDLEREL DDPGEQVLSH AHEQEEFVKE
160 170 180 190 200
KATPGAAQES SNDQFQTLEE QLGYNLREVC PVQEIDGKAG TWNVELAPKR
210 220 230 240 250
EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR VSSSVERPYI
260 270 280 290 300
CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
310 320 330 340 350
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK
360 370 380
HQRIHTGERP YECEECGKNF IYHCNLIQHR KVHPVAESS
Length:389
Mass (Da):44,955
Last modified:October 25, 2005 - v1
Checksum:iEE9B33F2D5F2F68C
GO

Sequence cautioni

The sequence CAC44641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
BC101559 mRNA. Translation: AAI01560.1.
BC101557 mRNA. Translation: AAI01558.1.
CCDSiCCDS47393.1.
RefSeqiNP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.2.
XP_011512708.1. XM_011514406.2.
XP_011512710.1. XM_011514408.2.
XP_011512712.1. XM_011514410.2.
XP_016865968.1. XM_017010479.1.
UniGeneiHs.721841.

Genome annotation databases

EnsembliENST00000289788; ENSP00000289788; ENSG00000187987.
GeneIDi222696.
KEGGihsa:222696.
UCSCiuc003nli.5. human.

Similar proteinsi

Entry informationi

Entry nameiZSC23_HUMAN
AccessioniPrimary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families