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Q3MJ62

- ZSC23_HUMAN

UniProt

Q3MJ62 - ZSC23_HUMAN

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Protein

Zinc finger and SCAN domain-containing protein 23

Gene

ZSCAN23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 23
Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453
Gene namesi
Name:ZSCAN23
Synonyms:ZNF390, ZNF453
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21193. ZSCAN23.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Zinc finger and SCAN domain-containing protein 23PRO_0000280411Add
BLAST

Proteomic databases

PaxDbiQ3MJ62.
PRIDEiQ3MJ62.

Expressioni

Gene expression databases

BgeeiQ3MJ62.
CleanExiHS_ZSCAN23.
ExpressionAtlasiQ3MJ62. baseline.
GenevestigatoriQ3MJ62.

Organism-specific databases

HPAiHPA035959.

Interactioni

Protein-protein interaction databases

BioGridi128813. 2 interactions.
IntActiQ3MJ62. 1 interaction.
STRINGi9606.ENSP00000289788.

Structurei

3D structure databases

ProteinModelPortaliQ3MJ62.
SMRiQ3MJ62. Positions 45-132, 215-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13083SCAN boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 275Poly-Glu

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ3MJ62.
KOiK09230.
OMAiAHEQEEF.
PhylomeDBiQ3MJ62.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MJ62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR
60 70 80 90 100
FRQFCYQESP GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL
110 120 130 140 150
PEELQAWVRQ HRPVSGEEAV TVLEDLEREL DDPGEQVLSH AHEQEEFVKE
160 170 180 190 200
KATPGAAQES SNDQFQTLEE QLGYNLREVC PVQEIDGKAG TWNVELAPKR
210 220 230 240 250
EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR VSSSVERPYI
260 270 280 290 300
CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
310 320 330 340 350
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK
360 370 380
HQRIHTGERP YECEECGKNF IYHCNLIQHR KVHPVAESS
Length:389
Mass (Da):44,955
Last modified:October 25, 2005 - v1
Checksum:iEE9B33F2D5F2F68C
GO

Sequence cautioni

The sequence CAC44641.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
BC101559 mRNA. Translation: AAI01560.1.
BC101557 mRNA. Translation: AAI01558.1.
CCDSiCCDS47393.1.
RefSeqiNP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.1.
UniGeneiHs.721841.

Genome annotation databases

EnsembliENST00000289788; ENSP00000289788; ENSG00000187987.
GeneIDi222696.
KEGGihsa:222696.
UCSCiuc003nli.4. human.

Polymorphism databases

DMDMi121949042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA. Translation: CAC44641.1 . Sequence problems.
BC101559 mRNA. Translation: AAI01560.1 .
BC101557 mRNA. Translation: AAI01558.1 .
CCDSi CCDS47393.1.
RefSeqi NP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.1.
UniGenei Hs.721841.

3D structure databases

ProteinModelPortali Q3MJ62.
SMRi Q3MJ62. Positions 45-132, 215-383.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128813. 2 interactions.
IntActi Q3MJ62. 1 interaction.
STRINGi 9606.ENSP00000289788.

Polymorphism databases

DMDMi 121949042.

Proteomic databases

PaxDbi Q3MJ62.
PRIDEi Q3MJ62.

Protocols and materials databases

DNASUi 222696.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289788 ; ENSP00000289788 ; ENSG00000187987 .
GeneIDi 222696.
KEGGi hsa:222696.
UCSCi uc003nli.4. human.

Organism-specific databases

CTDi 222696.
GeneCardsi GC06M028399.
HGNCi HGNC:21193. ZSCAN23.
HPAi HPA035959.
neXtProti NX_Q3MJ62.
PharmGKBi PA162410995.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118881.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi Q3MJ62.
KOi K09230.
OMAi AHEQEEF.
PhylomeDBi Q3MJ62.
TreeFami TF338304.

Miscellaneous databases

ChiTaRSi ZSCAN23. human.
GenomeRNAii 222696.
NextBioi 91663.
PROi Q3MJ62.

Gene expression databases

Bgeei Q3MJ62.
CleanExi HS_ZSCAN23.
ExpressionAtlasi Q3MJ62. baseline.
Genevestigatori Q3MJ62.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiZSC23_HUMAN
AccessioniPrimary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3