Q3MJ62 (ZSC23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 23

Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453

Gene names

Name:	ZSCAN23
Synonyms:	ZNF390, ZNF453

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. Contains 1 SCAN box domain.
Sequence caution	The sequence CAC44641.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Zinc finger and SCAN domain-containing protein 23		PRO_0000280411
Regions
	Domain	48 – 130	83	SCAN box
	Zinc finger	249 – 271	23	C2H2-type 1
	Zinc finger	277 – 299	23	C2H2-type 2
	Zinc finger	305 – 327	23	C2H2-type 3
	Zinc finger	333 – 355	23	C2H2-type 4
	Zinc finger	361 – 383	23	C2H2-type 5
	Compositional bias	23 – 27	5	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q3MJ62 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: EE9B33F2D5F2F68C	FASTA	389	44,955
	10 20 30 40 50 60 MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR FRQFCYQESP 70 80 90 100 110 120 GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL PEELQAWVRQ HRPVSGEEAV 130 140 150 160 170 180 TVLEDLEREL DDPGEQVLSH AHEQEEFVKE KATPGAAQES SNDQFQTLEE QLGYNLREVC 190 200 210 220 230 240 PVQEIDGKAG TWNVELAPKR EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR 250 260 270 280 290 300 VSSSVERPYI CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT 310 320 330 340 350 360 GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK HQRIHTGERP 370 380 YECEECGKNF IYHCNLIQHR KVHPVAESS

References

[1]

"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems. BC101559 mRNA. Translation: AAI01560.1. BC101557 mRNA. Translation: AAI01558.1.
IPI	IPI00896470.
RefSeq	NP_001012458.1. NM_001012455.1.
UniGene	Hs.721841.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q3MJ62.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3MJ62. 1 interaction.
STRING	9606.ENSP00000289788.
Polymorphism databases
DMDM	121949042.
Proteomic databases
PaxDb	Q3MJ62.
PRIDE	Q3MJ62.
Protocols and materials databases
DNASU	222696.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000289788; ENSP00000289788; ENSG00000187987.
GeneID	222696.
KEGG	hsa:222696.
UCSC	uc003nli.4. human.
Organism-specific databases
CTD	222696.
GeneCards	GC06M028399.
HGNC	HGNC:21193. ZSCAN23.
HPA	HPA035959.
neXtProt	NX_Q3MJ62.
PharmGKB	PA162410995.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234619.
HOVERGEN	HBG018163.
InParanoid	Q3MJ62.
KO	K09230.
OMA	AHEQEEF.
OrthoDB	EOG4XPQFZ.
Gene expression databases
ArrayExpress	Q3MJ62.
Bgee	Q3MJ62.
CleanEx	HS_ZSCAN23.
Genevestigator	Q3MJ62.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZSCAN23. human.
GenomeRNAi	222696.
NextBio	91663.

Entry information

Entry name

ZSC23_HUMAN

Accession

Primary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.