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Q3MJ62 (ZSC23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 23
Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453
Gene names
Name:ZSCAN23
Synonyms:ZNF390, ZNF453
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Sequence caution

The sequence CAC44641.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Zinc finger and SCAN domain-containing protein 23
PRO_0000280411

Regions

Domain48 – 13083SCAN box
Zinc finger249 – 27123C2H2-type 1
Zinc finger277 – 29923C2H2-type 2
Zinc finger305 – 32723C2H2-type 3
Zinc finger333 – 35523C2H2-type 4
Zinc finger361 – 38323C2H2-type 5
Compositional bias23 – 275Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q3MJ62 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: EE9B33F2D5F2F68C

FASTA38944,955
        10         20         30         40         50         60 
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR FRQFCYQESP 

        70         80         90        100        110        120 
GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL PEELQAWVRQ HRPVSGEEAV 

       130        140        150        160        170        180 
TVLEDLEREL DDPGEQVLSH AHEQEEFVKE KATPGAAQES SNDQFQTLEE QLGYNLREVC 

       190        200        210        220        230        240 
PVQEIDGKAG TWNVELAPKR EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR 

       250        260        270        280        290        300 
VSSSVERPYI CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT 

       310        320        330        340        350        360 
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK HQRIHTGERP 

       370        380 
YECEECGKNF IYHCNLIQHR KVHPVAESS 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
BC101559 mRNA. Translation: AAI01560.1.
BC101557 mRNA. Translation: AAI01558.1.
CCDSCCDS47393.1.
RefSeqNP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.1.
UniGeneHs.721841.

3D structure databases

ProteinModelPortalQ3MJ62.
SMRQ3MJ62. Positions 45-132, 215-383.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3MJ62. 1 interaction.
STRING9606.ENSP00000289788.

Polymorphism databases

DMDM121949042.

Proteomic databases

PaxDbQ3MJ62.
PRIDEQ3MJ62.

Protocols and materials databases

DNASU222696.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289788; ENSP00000289788; ENSG00000187987.
GeneID222696.
KEGGhsa:222696.
UCSCuc003nli.4. human.

Organism-specific databases

CTD222696.
GeneCardsGC06M028399.
HGNCHGNC:21193. ZSCAN23.
HPAHPA035959.
neXtProtNX_Q3MJ62.
PharmGKBPA162410995.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidQ3MJ62.
KOK09230.
OMAAHEQEEF.
PhylomeDBQ3MJ62.
TreeFamTF338304.

Gene expression databases

ArrayExpressQ3MJ62.
BgeeQ3MJ62.
CleanExHS_ZSCAN23.
GenevestigatorQ3MJ62.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZSCAN23. human.
GenomeRNAi222696.
NextBio91663.
PROQ3MJ62.

Entry information

Entry nameZSC23_HUMAN
AccessionPrimary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM