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Protein

Zinc finger and SCAN domain-containing protein 23

Gene

ZSCAN23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 23
Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453
Gene namesi
Name:ZSCAN23
Synonyms:ZNF390, ZNF453
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187987.9
HGNCiHGNC:21193 ZSCAN23
neXtProtiNX_Q3MJ62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187987
PharmGKBiPA162410995

Polymorphism and mutation databases

BioMutaiZSCAN23
DMDMi121949042

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804111 – 389Zinc finger and SCAN domain-containing protein 23Add BLAST389

Proteomic databases

EPDiQ3MJ62
MaxQBiQ3MJ62
PaxDbiQ3MJ62
PeptideAtlasiQ3MJ62
PRIDEiQ3MJ62

PTM databases

iPTMnetiQ3MJ62
PhosphoSitePlusiQ3MJ62

Expressioni

Gene expression databases

BgeeiENSG00000187987
CleanExiHS_ZSCAN23
ExpressionAtlasiQ3MJ62 baseline and differential
GenevisibleiQ3MJ62 HS

Organism-specific databases

HPAiHPA035959
HPA035960

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128813, 3 interactors
IntActiQ3MJ62, 18 interactors
STRINGi9606.ENSP00000289788

Structurei

3D structure databases

ProteinModelPortaliQ3MJ62
SMRiQ3MJ62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 130SCAN boxPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 27Poly-Glu5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ3MJ62
KOiK09230
OMAiTCDHEGR
OrthoDBiEOG091G09O3
PhylomeDBiQ3MJ62
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q3MJ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR
60 70 80 90 100
FRQFCYQESP GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL
110 120 130 140 150
PEELQAWVRQ HRPVSGEEAV TVLEDLEREL DDPGEQVLSH AHEQEEFVKE
160 170 180 190 200
KATPGAAQES SNDQFQTLEE QLGYNLREVC PVQEIDGKAG TWNVELAPKR
210 220 230 240 250
EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR VSSSVERPYI
260 270 280 290 300
CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
310 320 330 340 350
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK
360 370 380
HQRIHTGERP YECEECGKNF IYHCNLIQHR KVHPVAESS
Length:389
Mass (Da):44,955
Last modified:October 25, 2005 - v1
Checksum:iEE9B33F2D5F2F68C
GO

Sequence cautioni

The sequence CAC44641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA Translation: CAC44641.1 Sequence problems.
BC101559 mRNA Translation: AAI01560.1
BC101557 mRNA Translation: AAI01558.1
CCDSiCCDS47393.1
RefSeqiNP_001012458.1, NM_001012455.1
XP_005249007.1, XM_005248950.2
XP_011512708.1, XM_011514406.2
XP_011512710.1, XM_011514408.2
XP_011512712.1, XM_011514410.2
XP_016865968.1, XM_017010479.1
UniGeneiHs.721841

Genome annotation databases

EnsembliENST00000289788; ENSP00000289788; ENSG00000187987
GeneIDi222696
KEGGihsa:222696
UCSCiuc003nli.5 human

Similar proteinsi

Entry informationi

Entry nameiZSC23_HUMAN
AccessioniPrimary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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