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Protein

Zinc finger and SCAN domain-containing protein 23

Gene

ZSCAN23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 23
Alternative name(s):
Zinc finger protein 390
Zinc finger protein 453
Gene namesi
Name:ZSCAN23
Synonyms:ZNF390, ZNF453
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21193. ZSCAN23.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Zinc finger and SCAN domain-containing protein 23PRO_0000280411Add
BLAST

Proteomic databases

PaxDbiQ3MJ62.
PRIDEiQ3MJ62.

Expressioni

Gene expression databases

BgeeiQ3MJ62.
CleanExiHS_ZSCAN23.
ExpressionAtlasiQ3MJ62. baseline.
GenevestigatoriQ3MJ62.

Organism-specific databases

HPAiHPA035959.
HPA035960.

Interactioni

Protein-protein interaction databases

BioGridi128813. 2 interactions.
IntActiQ3MJ62. 1 interaction.
STRINGi9606.ENSP00000289788.

Structurei

3D structure databases

ProteinModelPortaliQ3MJ62.
SMRiQ3MJ62. Positions 45-132, 215-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13083SCAN boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 275Poly-Glu

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ3MJ62.
KOiK09230.
OMAiAHEQEEF.
PhylomeDBiQ3MJ62.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MJ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR
60 70 80 90 100
FRQFCYQESP GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL
110 120 130 140 150
PEELQAWVRQ HRPVSGEEAV TVLEDLEREL DDPGEQVLSH AHEQEEFVKE
160 170 180 190 200
KATPGAAQES SNDQFQTLEE QLGYNLREVC PVQEIDGKAG TWNVELAPKR
210 220 230 240 250
EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR VSSSVERPYI
260 270 280 290 300
CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT
310 320 330 340 350
GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK
360 370 380
HQRIHTGERP YECEECGKNF IYHCNLIQHR KVHPVAESS
Length:389
Mass (Da):44,955
Last modified:October 25, 2005 - v1
Checksum:iEE9B33F2D5F2F68C
GO

Sequence cautioni

The sequence CAC44641.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
BC101559 mRNA. Translation: AAI01560.1.
BC101557 mRNA. Translation: AAI01558.1.
CCDSiCCDS47393.1.
RefSeqiNP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.1.
UniGeneiHs.721841.

Genome annotation databases

EnsembliENST00000289788; ENSP00000289788; ENSG00000187987.
GeneIDi222696.
KEGGihsa:222696.
UCSCiuc003nli.4. human.

Polymorphism databases

DMDMi121949042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
BC101559 mRNA. Translation: AAI01560.1.
BC101557 mRNA. Translation: AAI01558.1.
CCDSiCCDS47393.1.
RefSeqiNP_001012458.1. NM_001012455.1.
XP_005249007.1. XM_005248950.1.
UniGeneiHs.721841.

3D structure databases

ProteinModelPortaliQ3MJ62.
SMRiQ3MJ62. Positions 45-132, 215-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128813. 2 interactions.
IntActiQ3MJ62. 1 interaction.
STRINGi9606.ENSP00000289788.

Polymorphism databases

DMDMi121949042.

Proteomic databases

PaxDbiQ3MJ62.
PRIDEiQ3MJ62.

Protocols and materials databases

DNASUi222696.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289788; ENSP00000289788; ENSG00000187987.
GeneIDi222696.
KEGGihsa:222696.
UCSCiuc003nli.4. human.

Organism-specific databases

CTDi222696.
GeneCardsiGC06M028399.
HGNCiHGNC:21193. ZSCAN23.
HPAiHPA035959.
HPA035960.
neXtProtiNX_Q3MJ62.
PharmGKBiPA162410995.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ3MJ62.
KOiK09230.
OMAiAHEQEEF.
PhylomeDBiQ3MJ62.
TreeFamiTF338304.

Miscellaneous databases

ChiTaRSiZSCAN23. human.
GenomeRNAii222696.
NextBioi91663.
PROiQ3MJ62.

Gene expression databases

BgeeiQ3MJ62.
CleanExiHS_ZSCAN23.
ExpressionAtlasiQ3MJ62. baseline.
GenevestigatoriQ3MJ62.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiZSC23_HUMAN
AccessioniPrimary (citable) accession number: Q3MJ62
Secondary accession number(s): Q96KV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: March 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.