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Q3MJ62

- ZSC23_HUMAN

UniProt

Q3MJ62 - ZSC23_HUMAN

Protein

Zinc finger and SCAN domain-containing protein 23

Gene

ZSCAN23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and SCAN domain-containing protein 23
    Alternative name(s):
    Zinc finger protein 390
    Zinc finger protein 453
    Gene namesi
    Name:ZSCAN23
    Synonyms:ZNF390, ZNF453
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21193. ZSCAN23.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410995.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Zinc finger and SCAN domain-containing protein 23PRO_0000280411Add
    BLAST

    Proteomic databases

    PaxDbiQ3MJ62.
    PRIDEiQ3MJ62.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3MJ62.
    BgeeiQ3MJ62.
    CleanExiHS_ZSCAN23.
    GenevestigatoriQ3MJ62.

    Organism-specific databases

    HPAiHPA035959.

    Interactioni

    Protein-protein interaction databases

    IntActiQ3MJ62. 1 interaction.
    STRINGi9606.ENSP00000289788.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MJ62.
    SMRiQ3MJ62. Positions 45-132, 215-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 13083SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 275Poly-Glu

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri249 – 27123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ3MJ62.
    KOiK09230.
    OMAiAHEQEEF.
    PhylomeDBiQ3MJ62.
    TreeFamiTF338304.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3MJ62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAITLTLQTA EMQEGLLAVK VKEEEEEHSC GPESGLSRNN PHTREIFRRR    50
    FRQFCYQESP GPREALQRLQ ELCHQWLRPE MHTKEQILEL LVLEQFLTIL 100
    PEELQAWVRQ HRPVSGEEAV TVLEDLEREL DDPGEQVLSH AHEQEEFVKE 150
    KATPGAAQES SNDQFQTLEE QLGYNLREVC PVQEIDGKAG TWNVELAPKR 200
    EISQEVKSLI QVLGKQNGNI TQIPEYGDTC DREGRLEKQR VSSSVERPYI 250
    CSECGKSFTQ NSILIEHQRT HTGEKPYECD ECGRAFSQRS GLFQHQRLHT 300
    GEKRYQCSVC GKAFSQNAGL FHHLRIHTGE KPYQCNQCNK SFSRRSVLIK 350
    HQRIHTGERP YECEECGKNF IYHCNLIQHR KVHPVAESS 389
    Length:389
    Mass (Da):44,955
    Last modified:October 25, 2005 - v1
    Checksum:iEE9B33F2D5F2F68C
    GO

    Sequence cautioni

    The sequence CAC44641.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98745 Genomic DNA. Translation: CAC44641.1. Sequence problems.
    BC101559 mRNA. Translation: AAI01560.1.
    BC101557 mRNA. Translation: AAI01558.1.
    CCDSiCCDS47393.1.
    RefSeqiNP_001012458.1. NM_001012455.1.
    XP_005249007.1. XM_005248950.1.
    UniGeneiHs.721841.

    Genome annotation databases

    EnsembliENST00000289788; ENSP00000289788; ENSG00000187987.
    GeneIDi222696.
    KEGGihsa:222696.
    UCSCiuc003nli.4. human.

    Polymorphism databases

    DMDMi121949042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98745 Genomic DNA. Translation: CAC44641.1 . Sequence problems.
    BC101559 mRNA. Translation: AAI01560.1 .
    BC101557 mRNA. Translation: AAI01558.1 .
    CCDSi CCDS47393.1.
    RefSeqi NP_001012458.1. NM_001012455.1.
    XP_005249007.1. XM_005248950.1.
    UniGenei Hs.721841.

    3D structure databases

    ProteinModelPortali Q3MJ62.
    SMRi Q3MJ62. Positions 45-132, 215-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3MJ62. 1 interaction.
    STRINGi 9606.ENSP00000289788.

    Polymorphism databases

    DMDMi 121949042.

    Proteomic databases

    PaxDbi Q3MJ62.
    PRIDEi Q3MJ62.

    Protocols and materials databases

    DNASUi 222696.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289788 ; ENSP00000289788 ; ENSG00000187987 .
    GeneIDi 222696.
    KEGGi hsa:222696.
    UCSCi uc003nli.4. human.

    Organism-specific databases

    CTDi 222696.
    GeneCardsi GC06M028399.
    HGNCi HGNC:21193. ZSCAN23.
    HPAi HPA035959.
    neXtProti NX_Q3MJ62.
    PharmGKBi PA162410995.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q3MJ62.
    KOi K09230.
    OMAi AHEQEEF.
    PhylomeDBi Q3MJ62.
    TreeFami TF338304.

    Miscellaneous databases

    ChiTaRSi ZSCAN23. human.
    GenomeRNAii 222696.
    NextBioi 91663.
    PROi Q3MJ62.

    Gene expression databases

    ArrayExpressi Q3MJ62.
    Bgeei Q3MJ62.
    CleanExi HS_ZSCAN23.
    Genevestigatori Q3MJ62.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiZSC23_HUMAN
    AccessioniPrimary (citable) accession number: Q3MJ62
    Secondary accession number(s): Q96KV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3