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Protein

Coiled-coil domain-containing protein 144B

Gene

CCDC144B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 144B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26704. CCDC144B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381474.

Polymorphism and mutation databases

DMDMi121942840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122801 – 725Coiled-coil domain-containing protein 144BAdd BLAST725

Proteomic databases

PaxDbiQ3MJ40.
PeptideAtlasiQ3MJ40.
PRIDEiQ3MJ40.

PTM databases

iPTMnetiQ3MJ40.
PhosphoSitePlusiQ3MJ40.

Expressioni

Gene expression databases

CleanExiHS_CCDC144B.

Organism-specific databases

HPAiHPA047220.
HPA047851.

Interactioni

Protein-protein interaction databases

DIPiDIP-47329N.
IntActiQ3MJ40. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ3MJ40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili215 – 244Sequence analysisAdd BLAST30
Coiled coili490 – 546Sequence analysisAdd BLAST57
Coiled coili648 – 713Sequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the CCDC144 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA18. Eukaryota.
ENOG4111BDS. LUCA.
HOVERGENiHBG106609.
InParanoidiQ3MJ40.
PhylomeDBiQ3MJ40.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3MJ40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWGGEKRG GAEGSPKLAV YATRKTRSVR SQEDQWYLGY PGDQWSSGFS
60 70 80 90 100
YSWWKNSVGS ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHVL
110 120 130 140 150
APGDTGVDKR DRKKSIQQLV PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE
160 170 180 190 200
TCQRSKNLKV GDKSPSVSPS MPENQSATKE LGQMNLTERE KMDTGVVLLS
210 220 230 240 250
GNDTLHDLCQ SQLPENKESK EAEQDLELTS EEEQERLKGC ENKQPQKTSQ
260 270 280 290 300
EPEMAKDCDR EDIPIYPVLP HVQKSEEMWI EQGKLEWKNQ LKLVINELKQ
310 320 330 340 350
RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS
360 370 380 390 400
EISVSVVFET FPEQKEPSLK NIIHPYYHPY SGSQEHVCQS SSKLHLHENK
410 420 430 440 450
LDCDNDNKLG IGHIFSTDNN FHNDASTKKA RNPEVVTVEM KEDQEFDLQM
460 470 480 490 500
TKNMNQNSDS GSTNNYKSLK PKLENLSSLP PDSDRTSEVY LHEELQQDMQ
510 520 530 540 550
KFKNEVNTLE EEFLALKKEN VQLHKEVEEE MEKHRSNSTE LSGTLTDGTT
560 570 580 590 600
VGNDDDGLNQ QIPRKENEEH DRPADKTANE KNKVKNQIYP EADFADSMEP
610 620 630 640 650
SEIASEDCEL SHSVYENFML LIEQLRMEYK DSASLPRIQD TFCLCEHLLK
660 670 680 690 700
LKNNHCDQLT VKLKQMENMV SVLQNELSET KKTKLQLELQ KIEWEKELYD
710 720
LRLALKQENG RKEMPICCII KIVNS
Length:725
Mass (Da):82,951
Last modified:October 25, 2005 - v1
Checksum:i7F77DCDCA99E87C6
GO
Isoform 2 (identifier: Q3MJ40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-222: Missing.
     573-725: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):65,017
Checksum:i569F627E8C3D2A0D
GO

Sequence cautioni

The sequence AAH62767 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370K → N in AK093811 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029792222Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_029793573 – 725Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093811 mRNA. No translation available.
EF553518 mRNA. Translation: ABQ66264.1.
AC026271 Genomic DNA. No translation available.
AC107983 Genomic DNA. No translation available.
BC062767 mRNA. Translation: AAH62767.1. Sequence problems.
BC101585 mRNA. Translation: AAI01586.1.
BC104815 mRNA. Translation: AAI04816.1.
UniGeneiHs.448012.
Hs.745246.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiC144B_HUMAN
AccessioniPrimary (citable) accession number: Q3MJ40
Secondary accession number(s): Q6P5Q3, Q8N200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 25, 2005
Last modified: February 15, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families