Q3MIX3 (ADCK5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized aarF domain-containing protein kinase 5
EC=2.7.11.-

Gene names

Name:

ADCK5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence AAH31570.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	Uncharacterized aarF domain-containing protein kinase 5		PRO_0000271800
Regions
	Transmembrane	50 – 67	18	Helical; Potential
	Domain	179 – 419	241	Protein kinase
Natural variations
	Natural variant	17	1	R → S. Ref.2 Ref.3 Corresponds to variant rs6599528 [ dbSNP | Ensembl ].		VAR_029996
Experimental info
	Sequence conflict	283	1	R → G in AAH85013. Ref.2
	Sequence conflict	324 – 338	15	NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3MIX3 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 26C1DB28EE8472E3	FASTA	580	65,897
	10 20 30 40 50 60 MWRPVQLCHF HSALLHRRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV LSTAVVGAPL 70 80 90 100 110 120 LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD YWWCTNVVLR GVEENSPGYL 130 140 150 160 170 180 EVMSACHQRA ADALVAGAIS NGGLYVKLGQ GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ 190 200 210 220 230 240 EVDELFLEDF QALPHELFQE FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG 250 260 270 280 290 300 DIHTLELLLR LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV 310 320 330 340 350 360 PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ IFYTGFIHSD 370 380 390 400 410 420 PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL WRAIILRDDA AMRAHAAALG 430 440 450 460 470 480 VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE EAAYMVDMAR ERFEAVMAVL RELPRPMLLV 490 500 510 520 530 540 LRNINTVRAI NVALGAPVDR YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK 550 560 570 580 FEVALRLETL AMRLTALLAR ALVHLSLVPP AEELYQYLET

References

[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-17. Tissue: Brain, Colon, Ovary and Prostate.
[3]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-17.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF205589 Genomic DNA. No translation available. BC031570 mRNA. Translation: AAH31570.1. Different initiation. BC064345 mRNA. Translation: AAH64345.1. BC085013 mRNA. Translation: AAH85013.1. BC101659 mRNA. Translation: AAI01660.1.
IPI	IPI00418366.
RefSeq	NP_777582.3. NM_174922.3.
UniGene	Hs.283374.
3D structure databases
ProteinModelPortal	Q3MIX3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3MIX3. 2 interactions.
STRING	9606.ENSP00000310547.
PTM databases
PhosphoSite	Q3MIX3.
Polymorphism databases
DMDM	121958055.
Proteomic databases
PaxDb	Q3MIX3.
PRIDE	Q3MIX3.
Protocols and materials databases
DNASU	203054.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308860; ENSP00000310547; ENSG00000173137. ENST00000563699; ENSP00000456977; ENSG00000261694.
GeneID	203054.
KEGG	hsa:203054.
UCSC	uc003zch.3. human.
Organism-specific databases
CTD	203054.
GeneCards	GC08P145596.
H-InvDB	HIX0201293.
HGNC	HGNC:21738. ADCK5.
HPA	HPA025692. HPA028679.
neXtProt	NX_Q3MIX3.
PharmGKB	PA134963849.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000240338.
HOVERGEN	HBG104406.
InParanoid	Q3MIX3.
KO	K08869.
OMA	REEAAYM.
OrthoDB	EOG4NP73D.
Gene expression databases
ArrayExpress	Q3MIX3.
Bgee	Q3MIX3.
CleanEx	HS_ADCK5.
Genevestigator	Q3MIX3.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADCK5. human.
GenomeRNAi	203054.
NextBio	90316.

Entry information

Entry name

ADCK5_HUMAN

Accession

Primary (citable) accession number: Q3MIX3
Secondary accession number(s): Q5U4P1, Q6P2S4, Q8N5V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.