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Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

ADCK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

GO - Molecular functioni

  1. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
Gene namesi
Name:ADCK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:21738. ADCK5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 6718HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Uncharacterized aarF domain-containing protein kinase 5PRO_0000271800Add
BLAST

Proteomic databases

MaxQBiQ3MIX3.
PaxDbiQ3MIX3.
PRIDEiQ3MIX3.

PTM databases

PhosphoSiteiQ3MIX3.

Expressioni

Gene expression databases

BgeeiQ3MIX3.
CleanExiHS_ADCK5.
GenevestigatoriQ3MIX3.

Organism-specific databases

HPAiHPA025692.
HPA028679.

Interactioni

Protein-protein interaction databases

BioGridi128442. 5 interactions.
IntActiQ3MIX3. 3 interactions.
STRINGi9606.ENSP00000310547.

Structurei

3D structure databases

ProteinModelPortaliQ3MIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 419241Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0661.
HOGENOMiHOG000240338.
HOVERGENiHBG104406.
InParanoidiQ3MIX3.
KOiK08869.
OMAiFAWVLQD.
PhylomeDBiQ3MIX3.
TreeFamiTF354300.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3MIX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRPVQLCHF HSALLHRRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV
60 70 80 90 100
LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD
110 120 130 140 150
YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ
160 170 180 190 200
GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE
210 220 230 240 250
FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR
260 270 280 290 300
LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV
310 320 330 340 350
PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ
360 370 380 390 400
IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL
410 420 430 440 450
WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE
460 470 480 490 500
EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR
510 520 530 540 550
YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL
560 570 580
AMRLTALLAR ALVHLSLVPP AEELYQYLET
Length:580
Mass (Da):65,897
Last modified:January 9, 2007 - v2
Checksum:i26C1DB28EE8472E3
GO

Sequence cautioni

The sequence AAH31570.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2751E → G in BAG52608 (PubMed:14702039).Curated
Sequence conflicti283 – 2831R → G in AAH85013 (PubMed:15489334).Curated
Sequence conflicti324 – 33815NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345 (PubMed:15489334).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171R → S.2 Publications
Corresponds to variant rs6599528 [ dbSNP | Ensembl ].
VAR_029996

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092773 mRNA. Translation: BAG52608.1.
AF205589 Genomic DNA. No translation available.
BC031570 mRNA. Translation: AAH31570.1. Different initiation.
BC064345 mRNA. Translation: AAH64345.1.
BC085013 mRNA. Translation: AAH85013.1.
BC101659 mRNA. Translation: AAI01660.1.
CCDSiCCDS34965.2.
RefSeqiNP_777582.4. NM_174922.4.
UniGeneiHs.283374.

Genome annotation databases

EnsembliENST00000308860; ENSP00000310547; ENSG00000173137.
GeneIDi203054.
KEGGihsa:203054.
UCSCiuc003zch.3. human.

Polymorphism databases

DMDMi121958055.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092773 mRNA. Translation: BAG52608.1.
AF205589 Genomic DNA. No translation available.
BC031570 mRNA. Translation: AAH31570.1. Different initiation.
BC064345 mRNA. Translation: AAH64345.1.
BC085013 mRNA. Translation: AAH85013.1.
BC101659 mRNA. Translation: AAI01660.1.
CCDSiCCDS34965.2.
RefSeqiNP_777582.4. NM_174922.4.
UniGeneiHs.283374.

3D structure databases

ProteinModelPortaliQ3MIX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128442. 5 interactions.
IntActiQ3MIX3. 3 interactions.
STRINGi9606.ENSP00000310547.

PTM databases

PhosphoSiteiQ3MIX3.

Polymorphism databases

DMDMi121958055.

Proteomic databases

MaxQBiQ3MIX3.
PaxDbiQ3MIX3.
PRIDEiQ3MIX3.

Protocols and materials databases

DNASUi203054.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308860; ENSP00000310547; ENSG00000173137.
GeneIDi203054.
KEGGihsa:203054.
UCSCiuc003zch.3. human.

Organism-specific databases

CTDi203054.
GeneCardsiGC08P145596.
H-InvDBHIX0201293.
HGNCiHGNC:21738. ADCK5.
HPAiHPA025692.
HPA028679.
neXtProtiNX_Q3MIX3.
PharmGKBiPA134963849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0661.
HOGENOMiHOG000240338.
HOVERGENiHBG104406.
InParanoidiQ3MIX3.
KOiK08869.
OMAiFAWVLQD.
PhylomeDBiQ3MIX3.
TreeFamiTF354300.

Miscellaneous databases

ChiTaRSiADCK5. human.
GenomeRNAii203054.
NextBioi90316.
PROiQ3MIX3.

Gene expression databases

BgeeiQ3MIX3.
CleanExiHS_ADCK5.
GenevestigatoriQ3MIX3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-17.
    Tissue: Brain, Colon, Ovary and Prostate.
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-17.

Entry informationi

Entry nameiADCK5_HUMAN
AccessioniPrimary (citable) accession number: Q3MIX3
Secondary accession number(s): B3KS46
, Q5U4P1, Q6P2S4, Q8N5V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: March 4, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.