Reviewed,
UniProtKB/Swiss-Prot Q3MIX3 (ADCK5_HUMAN)
Last modified
June 16, 2009.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Uncharacterized aarF domain-containing protein kinase 5 EC=2.7.11.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 580 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 580 | 580 | Uncharacterized aarF domain-containing protein kinase 5 | PRO_0000271800 | |||||
Regions | |||||||||
| Transmembrane | 50 – 67 | 18 | Potential | ||||||
| Domain | 179 – 419 | 241 | Protein kinase | ||||||
Natural variations | |||||||||
| Natural variant | 17 | 1 | R → S: dbSNP rs6599528. Ref.2 Ref.3 | VAR_029996 | |||||
Experimental info | |||||||||
| Sequence conflict | 283 | 1 | R → G in AAH85013. Ref.2 | ||||||
| Sequence conflict | 324 – 338 | 15 | NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345. Ref.2 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AF205589 Genomic DNA. No translation available. BC031570 mRNA. Translation: AAH31570.1. Different initiation. BC064345 mRNA. Translation: AAH64345.1. BC085013 mRNA. Translation: AAH85013.1. BC101659 mRNA. Translation: AAI01660.1. | |
| IPI | IPI00418366. |
| RefSeq | NP_777582.3. |
| UniGene | Hs.283374 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q3MIX3. |
Proteomic databases | |
| PRIDE | Q3MIX3. |
Genome annotation databases | |
| Ensembl | ENSG00000173137. Homo sapiens. [Contig view] |
| GeneID | 203054. |
| KEGG | hsa:203054. |
Organism-specific databases | |
| GeneCards | GC08P145561. |
| HGNC | HGNC:21738. ADCK5. |
| PharmGKB | PA134963849. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q3MIX3. |
| OMA | Q3MIX3. GQLWGSH. |
Gene expression databases | |
| Bgee | Q3MIX3. |
| CleanEx | HS_ADCK5. |
Family and domain databases | |
| InterPro | IPR004147. ABC_1. [Graphical view] |
| Pfam | PF03109. ABC1. 1 hit. [Graphical view] |
| PROSITE | PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 90316. |
Entry information
| Entry name | ADCK5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q3MIX3 Secondary accession number(s): Q5U4P1, Q6P2S4, Q8N5V3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


