Reviewed, UniProtKB/Swiss-Prot Q3MIX3 (ADCK5_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5
    EC=2.7.11.-

Gene names

Name:

ADCK5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	Uncharacterized aarF domain-containing protein kinase 5		PRO_0000271800
Regions
	Transmembrane	50 – 67	18	Potential
	Domain	179 – 419	241	Protein kinase
Natural variations
	Natural variant	17	1	R → S: dbSNP rs6599528. Ref.2 Ref.3		VAR_029996
Experimental info
	Sequence conflict	283	1	R → G in AAH85013. Ref.2
	Sequence conflict	324 – 338	15	NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3MIX3-1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 26C1DB28EE8472E3	FASTA	580	65,897
	10 20 30 40 50 60 MWRPVQLCHF HSALLHRRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV LSTAVVGAPL 70 80 90 100 110 120 LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD YWWCTNVVLR GVEENSPGYL 130 140 150 160 170 180 EVMSACHQRA ADALVAGAIS NGGLYVKLGQ GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ 190 200 210 220 230 240 EVDELFLEDF QALPHELFQE FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG 250 260 270 280 290 300 DIHTLELLLR LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV 310 320 330 340 350 360 PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ IFYTGFIHSD 370 380 390 400 410 420 PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL WRAIILRDDA AMRAHAAALG 430 440 450 460 470 480 VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE EAAYMVDMAR ERFEAVMAVL RELPRPMLLV 490 500 510 520 530 540 LRNINTVRAI NVALGAPVDR YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK 550 560 570 580 FEVALRLETL AMRLTALLAR ALVHLSLVPP AEELYQYLET

References

[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-17. Tissue: Brain, Colon, Ovary and Prostate.
[3]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-17.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF205589 Genomic DNA. No translation available. BC031570 mRNA. Translation: AAH31570.1. Different initiation. BC064345 mRNA. Translation: AAH64345.1. BC085013 mRNA. Translation: AAH85013.1. BC101659 mRNA. Translation: AAI01660.1.
IPI	IPI00418366.
RefSeq	NP_777582.3.
UniGene	Hs.283374
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q3MIX3.
Proteomic databases
PRIDE	Q3MIX3.
Genome annotation databases
Ensembl	ENSG00000173137. Homo sapiens. [Contig view]
GeneID	203054.
KEGG	hsa:203054.
Organism-specific databases
GeneCards	GC08P145561.
HGNC	HGNC:21738. ADCK5.
PharmGKB	PA134963849.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3MIX3.
OMA	Q3MIX3. GQLWGSH.
Gene expression databases
Bgee	Q3MIX3.
CleanEx	HS_ADCK5.
Family and domain databases
InterPro	IPR004147. ABC_1. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	90316.

Entry information

Entry name

ADCK5_HUMAN

Accession

Primary (citable) accession number: Q3MIX3
Secondary accession number(s): Q5U4P1, Q6P2S4, Q8N5V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)