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Q3MIX3

- ADCK5_HUMAN

UniProt

Q3MIX3 - ADCK5_HUMAN

Protein

Uncharacterized aarF domain-containing protein kinase 5

Gene

ADCK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

    GO - Molecular functioni

    1. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5 (EC:2.7.11.-)
    Gene namesi
    Name:ADCK5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:21738. ADCK5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134963849.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580Uncharacterized aarF domain-containing protein kinase 5PRO_0000271800Add
    BLAST

    Proteomic databases

    MaxQBiQ3MIX3.
    PaxDbiQ3MIX3.
    PRIDEiQ3MIX3.

    PTM databases

    PhosphoSiteiQ3MIX3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3MIX3.
    BgeeiQ3MIX3.
    CleanExiHS_ADCK5.
    GenevestigatoriQ3MIX3.

    Organism-specific databases

    HPAiHPA025692.
    HPA028679.

    Interactioni

    Protein-protein interaction databases

    BioGridi128442. 4 interactions.
    IntActiQ3MIX3. 3 interactions.
    STRINGi9606.ENSP00000310547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MIX3.
    SMRiQ3MIX3. Positions 309-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 6718HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 419241Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0661.
    HOGENOMiHOG000240338.
    HOVERGENiHBG104406.
    InParanoidiQ3MIX3.
    KOiK08869.
    OMAiHANELGI.
    PhylomeDBiQ3MIX3.
    TreeFamiTF354300.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q3MIX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRPVQLCHF HSALLHRRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV    50
    LSTAVVGAPL LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD 100
    YWWCTNVVLR GVEENSPGYL EVMSACHQRA ADALVAGAIS NGGLYVKLGQ 150
    GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ EVDELFLEDF QALPHELFQE 200
    FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG DIHTLELLLR 250
    LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV 300
    PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ 350
    IFYTGFIHSD PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL 400
    WRAIILRDDA AMRAHAAALG VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE 450
    EAAYMVDMAR ERFEAVMAVL RELPRPMLLV LRNINTVRAI NVALGAPVDR 500
    YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK FEVALRLETL 550
    AMRLTALLAR ALVHLSLVPP AEELYQYLET 580
    Length:580
    Mass (Da):65,897
    Last modified:January 9, 2007 - v2
    Checksum:i26C1DB28EE8472E3
    GO

    Sequence cautioni

    The sequence AAH31570.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti275 – 2751E → G in BAG52608. (PubMed:14702039)Curated
    Sequence conflicti283 – 2831R → G in AAH85013. (PubMed:15489334)Curated
    Sequence conflicti324 – 33815NDVEA…LAVHD → GGLVLCPLQCLSSPQ in AAH64345. (PubMed:15489334)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171R → S.2 Publications
    Corresponds to variant rs6599528 [ dbSNP | Ensembl ].
    VAR_029996

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092773 mRNA. Translation: BAG52608.1.
    AF205589 Genomic DNA. No translation available.
    BC031570 mRNA. Translation: AAH31570.1. Different initiation.
    BC064345 mRNA. Translation: AAH64345.1.
    BC085013 mRNA. Translation: AAH85013.1.
    BC101659 mRNA. Translation: AAI01660.1.
    CCDSiCCDS34965.1.
    RefSeqiNP_777582.4. NM_174922.4.
    UniGeneiHs.283374.

    Genome annotation databases

    EnsembliENST00000308860; ENSP00000310547; ENSG00000173137.
    GeneIDi203054.
    KEGGihsa:203054.
    UCSCiuc003zch.3. human.

    Polymorphism databases

    DMDMi121958055.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092773 mRNA. Translation: BAG52608.1 .
    AF205589 Genomic DNA. No translation available.
    BC031570 mRNA. Translation: AAH31570.1 . Different initiation.
    BC064345 mRNA. Translation: AAH64345.1 .
    BC085013 mRNA. Translation: AAH85013.1 .
    BC101659 mRNA. Translation: AAI01660.1 .
    CCDSi CCDS34965.1.
    RefSeqi NP_777582.4. NM_174922.4.
    UniGenei Hs.283374.

    3D structure databases

    ProteinModelPortali Q3MIX3.
    SMRi Q3MIX3. Positions 309-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128442. 4 interactions.
    IntActi Q3MIX3. 3 interactions.
    STRINGi 9606.ENSP00000310547.

    PTM databases

    PhosphoSitei Q3MIX3.

    Polymorphism databases

    DMDMi 121958055.

    Proteomic databases

    MaxQBi Q3MIX3.
    PaxDbi Q3MIX3.
    PRIDEi Q3MIX3.

    Protocols and materials databases

    DNASUi 203054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308860 ; ENSP00000310547 ; ENSG00000173137 .
    GeneIDi 203054.
    KEGGi hsa:203054.
    UCSCi uc003zch.3. human.

    Organism-specific databases

    CTDi 203054.
    GeneCardsi GC08P145596.
    H-InvDB HIX0201293.
    HGNCi HGNC:21738. ADCK5.
    HPAi HPA025692.
    HPA028679.
    neXtProti NX_Q3MIX3.
    PharmGKBi PA134963849.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0661.
    HOGENOMi HOG000240338.
    HOVERGENi HBG104406.
    InParanoidi Q3MIX3.
    KOi K08869.
    OMAi HANELGI.
    PhylomeDBi Q3MIX3.
    TreeFami TF354300.

    Miscellaneous databases

    ChiTaRSi ADCK5. human.
    GenomeRNAii 203054.
    NextBioi 90316.
    PROi Q3MIX3.

    Gene expression databases

    ArrayExpressi Q3MIX3.
    Bgeei Q3MIX3.
    CleanExi HS_ADCK5.
    Genevestigatori Q3MIX3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-17.
      Tissue: Brain, Colon, Ovary and Prostate.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-17.

    Entry informationi

    Entry nameiADCK5_HUMAN
    AccessioniPrimary (citable) accession number: Q3MIX3
    Secondary accession number(s): B3KS46
    , Q5U4P1, Q6P2S4, Q8N5V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3