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Protein

Zinc finger protein 528

Gene

ZNF528

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 528
Gene namesi
Name:ZNF528
Synonyms:KIAA1827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29384. ZNF528.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Zinc finger protein 528PRO_0000280418Add
BLAST

Proteomic databases

PaxDbiQ3MIS6.
PRIDEiQ3MIS6.

PTM databases

PhosphoSiteiQ3MIS6.

Expressioni

Gene expression databases

BgeeiQ3MIS6.
CleanExiHS_ZNF528.
ExpressionAtlasiQ3MIS6. baseline and differential.
GenevestigatoriQ3MIS6.

Interactioni

Protein-protein interaction databases

BioGridi124076. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3MIS6.
SMRiQ3MIS6. Positions 128-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118917.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3MIS6.
KOiK09228.
OMAiCHECDKV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3MIS6.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3MIS6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGPLKF MDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIC
60 70 80 90 100
LPDLSVTSML EQKRDPWTLQ SEEKIANDPD GRECIKGVNT ERSSKLGSNA
110 120 130 140 150
GNKPCKNQLG FTFQLHLSDL QLFQAERKIS GCKHFEKPVS DNSSVSPLEK
160 170 180 190 200
ISSSVKSHLL NKYRNNFDHA PLLPQEQKAH IREKAYKCNE HGQVFRASAS
210 220 230 240 250
LTNQVIHNAD NPYKCSECGK VFSCSSKLVI HRRMHTGEKP YKCHECGKLF
260 270 280 290 300
SSNSNLSQHQ RIHTGEKPYK CHECDKVFRS SSKLAQHQRI HTGEKPYKCH
310 320 330 340 350
ECDKVFNQIA HLVRHQKIHT GEKPYSCNKC GKVFSRHSYL AEHQTVHTGE
360 370 380 390 400
KPYKCEECGK AFSVRSSLIT HQLIHTGRKP YKCKECDKVF GRKCFLTSHQ
410 420 430 440 450
RIHTRERPYG CSQCGKIFSQ KSDLIRHRKT HTDEKPYKCN KCGTAFREFS
460 470 480 490 500
DLTAHFLIHS GEKPYECKEC GKVFRYKSSL TSHHRIHTGE KPYKCNRCGK
510 520 530 540 550
VFSRSSNLVC HQKIHTGEKP YKCNQCGKVF NQASYLTRHQ IIHTGERPYR
560 570 580 590 600
CSKCGKAFRG CSGLTAHLAI HTEKKSHECK ECGKIFTQKS SLTNHHRIHI
610 620
GEKPYKCTLC SKVFSHNSDL AQHQRVHS
Length:628
Mass (Da):72,138
Last modified:October 25, 2005 - v1
Checksum:iBB8704D4A354ED11
GO
Isoform 2 (identifier: Q3MIS6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:395
Mass (Da):45,715
Checksum:i04D697F0F7C21732
GO

Sequence cautioni

The sequence BAB47456.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971Y → H in CAD89949. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti419 – 4191S → N.
Corresponds to variant rs324109 [ dbSNP | Ensembl ].
VAR_052858

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 233233Missing in isoform 2. 2 PublicationsVSP_023662Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1.
AL832630 mRNA. Translation: CAD89949.1.
CH471135 Genomic DNA. Translation: EAW72078.1.
BC101712 mRNA. Translation: AAI01713.1.
BC111950 mRNA. Translation: AAI11951.1.
AB058730 mRNA. Translation: BAB47456.1. Different initiation.
CCDSiCCDS33091.1. [Q3MIS6-1]
RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
XP_006723482.1. XM_006723419.1. [Q3MIS6-2]
UniGeneiHs.662043.

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
GeneIDi84436.
KEGGihsa:84436.
UCSCiuc002pzh.3. human. [Q3MIS6-1]

Polymorphism databases

DMDMi121942828.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1.
AL832630 mRNA. Translation: CAD89949.1.
CH471135 Genomic DNA. Translation: EAW72078.1.
BC101712 mRNA. Translation: AAI01713.1.
BC111950 mRNA. Translation: AAI11951.1.
AB058730 mRNA. Translation: BAB47456.1. Different initiation.
CCDSiCCDS33091.1. [Q3MIS6-1]
RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
XP_006723482.1. XM_006723419.1. [Q3MIS6-2]
UniGeneiHs.662043.

3D structure databases

ProteinModelPortaliQ3MIS6.
SMRiQ3MIS6. Positions 128-628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124076. 2 interactions.

PTM databases

PhosphoSiteiQ3MIS6.

Polymorphism databases

DMDMi121942828.

Proteomic databases

PaxDbiQ3MIS6.
PRIDEiQ3MIS6.

Protocols and materials databases

DNASUi84436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
GeneIDi84436.
KEGGihsa:84436.
UCSCiuc002pzh.3. human. [Q3MIS6-1]

Organism-specific databases

CTDi84436.
GeneCardsiGC19P052901.
HGNCiHGNC:29384. ZNF528.
MIMi615580. gene.
neXtProtiNX_Q3MIS6.
PharmGKBiPA134869369.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118917.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3MIS6.
KOiK09228.
OMAiCHECDKV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3MIS6.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii84436.
NextBioi74179.
PROiQ3MIS6.
SOURCEiSearch...

Gene expression databases

BgeeiQ3MIS6.
CleanExiHS_ZNF528.
ExpressionAtlasiQ3MIS6. baseline and differential.
GenevestigatoriQ3MIS6.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spinal cord.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart and Lung.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-628 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN528_HUMAN
AccessioniPrimary (citable) accession number: Q3MIS6
Secondary accession number(s): B3KPN4, Q86T88, Q96JK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.