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Protein

Zinc finger protein 528

Gene

ZNF528

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 235C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167555-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 528
Gene namesi
Name:ZNF528
Synonyms:KIAA1827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29384. ZNF528.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167555.
PharmGKBiPA134869369.

Polymorphism and mutation databases

BioMutaiZNF528.
DMDMi121942828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804181 – 628Zinc finger protein 528Add BLAST628

Proteomic databases

EPDiQ3MIS6.
MaxQBiQ3MIS6.
PaxDbiQ3MIS6.
PeptideAtlasiQ3MIS6.
PRIDEiQ3MIS6.

PTM databases

iPTMnetiQ3MIS6.
PhosphoSitePlusiQ3MIS6.

Expressioni

Gene expression databases

BgeeiENSG00000167555.
CleanExiHS_ZNF528.
ExpressionAtlasiQ3MIS6. baseline and differential.
GenevisibleiQ3MIS6. HS.

Interactioni

Protein-protein interaction databases

BioGridi124076. 1 interactor.
STRINGi9606.ENSP00000353652.

Structurei

3D structure databases

ProteinModelPortaliQ3MIS6.
SMRiQ3MIS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri213 – 235C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3MIS6.
KOiK09228.
OMAiKISGCKH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3MIS6.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3MIS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGPLKF MDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIC
60 70 80 90 100
LPDLSVTSML EQKRDPWTLQ SEEKIANDPD GRECIKGVNT ERSSKLGSNA
110 120 130 140 150
GNKPCKNQLG FTFQLHLSDL QLFQAERKIS GCKHFEKPVS DNSSVSPLEK
160 170 180 190 200
ISSSVKSHLL NKYRNNFDHA PLLPQEQKAH IREKAYKCNE HGQVFRASAS
210 220 230 240 250
LTNQVIHNAD NPYKCSECGK VFSCSSKLVI HRRMHTGEKP YKCHECGKLF
260 270 280 290 300
SSNSNLSQHQ RIHTGEKPYK CHECDKVFRS SSKLAQHQRI HTGEKPYKCH
310 320 330 340 350
ECDKVFNQIA HLVRHQKIHT GEKPYSCNKC GKVFSRHSYL AEHQTVHTGE
360 370 380 390 400
KPYKCEECGK AFSVRSSLIT HQLIHTGRKP YKCKECDKVF GRKCFLTSHQ
410 420 430 440 450
RIHTRERPYG CSQCGKIFSQ KSDLIRHRKT HTDEKPYKCN KCGTAFREFS
460 470 480 490 500
DLTAHFLIHS GEKPYECKEC GKVFRYKSSL TSHHRIHTGE KPYKCNRCGK
510 520 530 540 550
VFSRSSNLVC HQKIHTGEKP YKCNQCGKVF NQASYLTRHQ IIHTGERPYR
560 570 580 590 600
CSKCGKAFRG CSGLTAHLAI HTEKKSHECK ECGKIFTQKS SLTNHHRIHI
610 620
GEKPYKCTLC SKVFSHNSDL AQHQRVHS
Length:628
Mass (Da):72,138
Last modified:October 25, 2005 - v1
Checksum:iBB8704D4A354ED11
GO
Isoform 2 (identifier: Q3MIS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:395
Mass (Da):45,715
Checksum:i04D697F0F7C21732
GO

Sequence cautioni

The sequence BAB47456 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297Y → H in CAD89949 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052858419S → N.Corresponds to variant rs324109dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236621 – 233Missing in isoform 2. 2 PublicationsAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1.
AL832630 mRNA. Translation: CAD89949.1.
CH471135 Genomic DNA. Translation: EAW72078.1.
BC101712 mRNA. Translation: AAI01713.1.
BC111950 mRNA. Translation: AAI11951.1.
AB058730 mRNA. Translation: BAB47456.1. Different initiation.
CCDSiCCDS33091.1. [Q3MIS6-1]
RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
UniGeneiHs.662043.

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
GeneIDi84436.
KEGGihsa:84436.
UCSCiuc002pzh.3. human. [Q3MIS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1.
AL832630 mRNA. Translation: CAD89949.1.
CH471135 Genomic DNA. Translation: EAW72078.1.
BC101712 mRNA. Translation: AAI01713.1.
BC111950 mRNA. Translation: AAI11951.1.
AB058730 mRNA. Translation: BAB47456.1. Different initiation.
CCDSiCCDS33091.1. [Q3MIS6-1]
RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
UniGeneiHs.662043.

3D structure databases

ProteinModelPortaliQ3MIS6.
SMRiQ3MIS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124076. 1 interactor.
STRINGi9606.ENSP00000353652.

PTM databases

iPTMnetiQ3MIS6.
PhosphoSitePlusiQ3MIS6.

Polymorphism and mutation databases

BioMutaiZNF528.
DMDMi121942828.

Proteomic databases

EPDiQ3MIS6.
MaxQBiQ3MIS6.
PaxDbiQ3MIS6.
PeptideAtlasiQ3MIS6.
PRIDEiQ3MIS6.

Protocols and materials databases

DNASUi84436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
GeneIDi84436.
KEGGihsa:84436.
UCSCiuc002pzh.3. human. [Q3MIS6-1]

Organism-specific databases

CTDi84436.
GeneCardsiZNF528.
HGNCiHGNC:29384. ZNF528.
MIMi615580. gene.
neXtProtiNX_Q3MIS6.
OpenTargetsiENSG00000167555.
PharmGKBiPA134869369.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3MIS6.
KOiK09228.
OMAiKISGCKH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3MIS6.
TreeFamiTF341892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167555-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii84436.
PROiQ3MIS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167555.
CleanExiHS_ZNF528.
ExpressionAtlasiQ3MIS6. baseline and differential.
GenevisibleiQ3MIS6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN528_HUMAN
AccessioniPrimary (citable) accession number: Q3MIS6
Secondary accession number(s): B3KPN4, Q86T88, Q96JK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.