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Q3MIS6

- ZN528_HUMAN

UniProt

Q3MIS6 - ZN528_HUMAN

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Protein

Zinc finger protein 528

Gene

ZNF528

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 528
Gene namesi
Name:ZNF528
Synonyms:KIAA1827
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29384. ZNF528.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Zinc finger protein 528PRO_0000280418Add
BLAST

Proteomic databases

PaxDbiQ3MIS6.
PRIDEiQ3MIS6.

PTM databases

PhosphoSiteiQ3MIS6.

Expressioni

Gene expression databases

BgeeiQ3MIS6.
CleanExiHS_ZNF528.
ExpressionAtlasiQ3MIS6. baseline and differential.
GenevestigatoriQ3MIS6.

Interactioni

Protein-protein interaction databases

BioGridi124076. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3MIS6.
SMRiQ3MIS6. Positions 128-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3MIS6.
KOiK09228.
OMAiCHECDKV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ3MIS6.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3MIS6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQGPLKF MDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIC
60 70 80 90 100
LPDLSVTSML EQKRDPWTLQ SEEKIANDPD GRECIKGVNT ERSSKLGSNA
110 120 130 140 150
GNKPCKNQLG FTFQLHLSDL QLFQAERKIS GCKHFEKPVS DNSSVSPLEK
160 170 180 190 200
ISSSVKSHLL NKYRNNFDHA PLLPQEQKAH IREKAYKCNE HGQVFRASAS
210 220 230 240 250
LTNQVIHNAD NPYKCSECGK VFSCSSKLVI HRRMHTGEKP YKCHECGKLF
260 270 280 290 300
SSNSNLSQHQ RIHTGEKPYK CHECDKVFRS SSKLAQHQRI HTGEKPYKCH
310 320 330 340 350
ECDKVFNQIA HLVRHQKIHT GEKPYSCNKC GKVFSRHSYL AEHQTVHTGE
360 370 380 390 400
KPYKCEECGK AFSVRSSLIT HQLIHTGRKP YKCKECDKVF GRKCFLTSHQ
410 420 430 440 450
RIHTRERPYG CSQCGKIFSQ KSDLIRHRKT HTDEKPYKCN KCGTAFREFS
460 470 480 490 500
DLTAHFLIHS GEKPYECKEC GKVFRYKSSL TSHHRIHTGE KPYKCNRCGK
510 520 530 540 550
VFSRSSNLVC HQKIHTGEKP YKCNQCGKVF NQASYLTRHQ IIHTGERPYR
560 570 580 590 600
CSKCGKAFRG CSGLTAHLAI HTEKKSHECK ECGKIFTQKS SLTNHHRIHI
610 620
GEKPYKCTLC SKVFSHNSDL AQHQRVHS
Length:628
Mass (Da):72,138
Last modified:October 25, 2005 - v1
Checksum:iBB8704D4A354ED11
GO
Isoform 2 (identifier: Q3MIS6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:395
Mass (Da):45,715
Checksum:i04D697F0F7C21732
GO

Sequence cautioni

The sequence BAB47456.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971Y → H in CAD89949. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti419 – 4191S → N.
Corresponds to variant rs324109 [ dbSNP | Ensembl ].
VAR_052858

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 233233Missing in isoform 2. 2 PublicationsVSP_023662Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1.
AL832630 mRNA. Translation: CAD89949.1.
CH471135 Genomic DNA. Translation: EAW72078.1.
BC101712 mRNA. Translation: AAI01713.1.
BC111950 mRNA. Translation: AAI11951.1.
AB058730 mRNA. Translation: BAB47456.1. Different initiation.
CCDSiCCDS33091.1. [Q3MIS6-1]
RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
XP_006723482.1. XM_006723419.1. [Q3MIS6-2]
UniGeneiHs.662043.

Genome annotation databases

EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
GeneIDi84436.
KEGGihsa:84436.
UCSCiuc002pzh.3. human. [Q3MIS6-1]

Polymorphism databases

DMDMi121942828.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056552 mRNA. Translation: BAG51746.1 .
AL832630 mRNA. Translation: CAD89949.1 .
CH471135 Genomic DNA. Translation: EAW72078.1 .
BC101712 mRNA. Translation: AAI01713.1 .
BC111950 mRNA. Translation: AAI11951.1 .
AB058730 mRNA. Translation: BAB47456.1 . Different initiation.
CCDSi CCDS33091.1. [Q3MIS6-1 ]
RefSeqi NP_115799.2. NM_032423.2. [Q3MIS6-1 ]
XP_006723482.1. XM_006723419.1. [Q3MIS6-2 ]
UniGenei Hs.662043.

3D structure databases

ProteinModelPortali Q3MIS6.
SMRi Q3MIS6. Positions 128-628.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124076. 2 interactions.

PTM databases

PhosphoSitei Q3MIS6.

Polymorphism databases

DMDMi 121942828.

Proteomic databases

PaxDbi Q3MIS6.
PRIDEi Q3MIS6.

Protocols and materials databases

DNASUi 84436.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360465 ; ENSP00000353652 ; ENSG00000167555 . [Q3MIS6-1 ]
GeneIDi 84436.
KEGGi hsa:84436.
UCSCi uc002pzh.3. human. [Q3MIS6-1 ]

Organism-specific databases

CTDi 84436.
GeneCardsi GC19P052901.
HGNCi HGNC:29384. ZNF528.
MIMi 615580. gene.
neXtProti NX_Q3MIS6.
PharmGKBi PA134869369.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00690000102079.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q3MIS6.
KOi K09228.
OMAi CHECDKV.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q3MIS6.
TreeFami TF341892.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 84436.
NextBioi 74179.
PROi Q3MIS6.
SOURCEi Search...

Gene expression databases

Bgeei Q3MIS6.
CleanExi HS_ZNF528.
ExpressionAtlasi Q3MIS6. baseline and differential.
Genevestigatori Q3MIS6.

Family and domain databases

Gene3Di 3.30.160.60. 15 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spinal cord.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart and Lung.
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-628 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN528_HUMAN
AccessioniPrimary (citable) accession number: Q3MIS6
Secondary accession number(s): B3KPN4, Q86T88, Q96JK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 25, 2005
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3