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Q3MIS6

- ZN528_HUMAN

UniProt

Q3MIS6 - ZN528_HUMAN

Protein

Zinc finger protein 528

Gene

ZNF528

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 528
    Gene namesi
    Name:ZNF528
    Synonyms:KIAA1827
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29384. ZNF528.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869369.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Zinc finger protein 528PRO_0000280418Add
    BLAST

    Proteomic databases

    PaxDbiQ3MIS6.
    PRIDEiQ3MIS6.

    PTM databases

    PhosphoSiteiQ3MIS6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3MIS6.
    BgeeiQ3MIS6.
    CleanExiHS_ZNF528.
    GenevestigatoriQ3MIS6.

    Interactioni

    Protein-protein interaction databases

    BioGridi124076. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MIS6.
    SMRiQ3MIS6. Positions 128-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri213 – 23523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri241 – 26323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri269 – 29123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri297 – 31923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri577 – 59923C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri605 – 62723C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    KOiK09228.
    OMAiCHECDKV.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ3MIS6.
    TreeFamiTF341892.

    Family and domain databases

    Gene3Di3.30.160.60. 15 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3MIS6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALTQGPLKF MDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLGIC    50
    LPDLSVTSML EQKRDPWTLQ SEEKIANDPD GRECIKGVNT ERSSKLGSNA 100
    GNKPCKNQLG FTFQLHLSDL QLFQAERKIS GCKHFEKPVS DNSSVSPLEK 150
    ISSSVKSHLL NKYRNNFDHA PLLPQEQKAH IREKAYKCNE HGQVFRASAS 200
    LTNQVIHNAD NPYKCSECGK VFSCSSKLVI HRRMHTGEKP YKCHECGKLF 250
    SSNSNLSQHQ RIHTGEKPYK CHECDKVFRS SSKLAQHQRI HTGEKPYKCH 300
    ECDKVFNQIA HLVRHQKIHT GEKPYSCNKC GKVFSRHSYL AEHQTVHTGE 350
    KPYKCEECGK AFSVRSSLIT HQLIHTGRKP YKCKECDKVF GRKCFLTSHQ 400
    RIHTRERPYG CSQCGKIFSQ KSDLIRHRKT HTDEKPYKCN KCGTAFREFS 450
    DLTAHFLIHS GEKPYECKEC GKVFRYKSSL TSHHRIHTGE KPYKCNRCGK 500
    VFSRSSNLVC HQKIHTGEKP YKCNQCGKVF NQASYLTRHQ IIHTGERPYR 550
    CSKCGKAFRG CSGLTAHLAI HTEKKSHECK ECGKIFTQKS SLTNHHRIHI 600
    GEKPYKCTLC SKVFSHNSDL AQHQRVHS 628
    Length:628
    Mass (Da):72,138
    Last modified:October 25, 2005 - v1
    Checksum:iBB8704D4A354ED11
    GO
    Isoform 2 (identifier: Q3MIS6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-233: Missing.

    Show »
    Length:395
    Mass (Da):45,715
    Checksum:i04D697F0F7C21732
    GO

    Sequence cautioni

    The sequence BAB47456.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971Y → H in CAD89949. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti419 – 4191S → N.
    Corresponds to variant rs324109 [ dbSNP | Ensembl ].
    VAR_052858

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 233233Missing in isoform 2. 2 PublicationsVSP_023662Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056552 mRNA. Translation: BAG51746.1.
    AL832630 mRNA. Translation: CAD89949.1.
    CH471135 Genomic DNA. Translation: EAW72078.1.
    BC101712 mRNA. Translation: AAI01713.1.
    BC111950 mRNA. Translation: AAI11951.1.
    AB058730 mRNA. Translation: BAB47456.1. Different initiation.
    CCDSiCCDS33091.1. [Q3MIS6-1]
    RefSeqiNP_115799.2. NM_032423.2. [Q3MIS6-1]
    XP_006723482.1. XM_006723419.1. [Q3MIS6-2]
    UniGeneiHs.662043.

    Genome annotation databases

    EnsembliENST00000360465; ENSP00000353652; ENSG00000167555. [Q3MIS6-1]
    GeneIDi84436.
    KEGGihsa:84436.
    UCSCiuc002pzh.3. human. [Q3MIS6-1]

    Polymorphism databases

    DMDMi121942828.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056552 mRNA. Translation: BAG51746.1 .
    AL832630 mRNA. Translation: CAD89949.1 .
    CH471135 Genomic DNA. Translation: EAW72078.1 .
    BC101712 mRNA. Translation: AAI01713.1 .
    BC111950 mRNA. Translation: AAI11951.1 .
    AB058730 mRNA. Translation: BAB47456.1 . Different initiation.
    CCDSi CCDS33091.1. [Q3MIS6-1 ]
    RefSeqi NP_115799.2. NM_032423.2. [Q3MIS6-1 ]
    XP_006723482.1. XM_006723419.1. [Q3MIS6-2 ]
    UniGenei Hs.662043.

    3D structure databases

    ProteinModelPortali Q3MIS6.
    SMRi Q3MIS6. Positions 128-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124076. 2 interactions.

    PTM databases

    PhosphoSitei Q3MIS6.

    Polymorphism databases

    DMDMi 121942828.

    Proteomic databases

    PaxDbi Q3MIS6.
    PRIDEi Q3MIS6.

    Protocols and materials databases

    DNASUi 84436.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360465 ; ENSP00000353652 ; ENSG00000167555 . [Q3MIS6-1 ]
    GeneIDi 84436.
    KEGGi hsa:84436.
    UCSCi uc002pzh.3. human. [Q3MIS6-1 ]

    Organism-specific databases

    CTDi 84436.
    GeneCardsi GC19P052901.
    HGNCi HGNC:29384. ZNF528.
    MIMi 615580. gene.
    neXtProti NX_Q3MIS6.
    PharmGKBi PA134869369.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    KOi K09228.
    OMAi CHECDKV.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q3MIS6.
    TreeFami TF341892.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 84436.
    NextBioi 74179.
    PROi Q3MIS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3MIS6.
    Bgeei Q3MIS6.
    CleanExi HS_ZNF528.
    Genevestigatori Q3MIS6.

    Family and domain databases

    Gene3Di 3.30.160.60. 15 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spinal cord.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Heart and Lung.
    5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-628 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiZN528_HUMAN
    AccessioniPrimary (citable) accession number: Q3MIS6
    Secondary accession number(s): B3KPN4, Q86T88, Q96JK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3