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Q3MIR4

- CC50B_HUMAN

UniProt

Q3MIR4 - CC50B_HUMAN

Protein

Cell cycle control protein 50B

Gene

TMEM30B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate Probable. Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.1 PublicationCurated

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell cycle control protein 50B
    Alternative name(s):
    P4-ATPase flippase complex beta subunit TMEM30B
    Transmembrane protein 30B
    Gene namesi
    Name:TMEM30B
    Synonyms:CDC50B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:27254. TMEM30B.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134993260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Cell cycle control protein 50BPRO_0000244474Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ3MIR4.
    PaxDbiQ3MIR4.
    PRIDEiQ3MIR4.

    Expressioni

    Gene expression databases

    BgeeiQ3MIR4.
    CleanExiHS_TMEM30B.
    GenevestigatoriQ3MIR4.

    Organism-specific databases

    HPAiHPA043162.

    Interactioni

    Subunit structurei

    Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit Probable. Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4.3 PublicationsCurated

    Protein-protein interaction databases

    BioGridi127780. 1 interaction.
    IntActiQ3MIR4. 3 interactions.
    MINTiMINT-5004611.
    STRINGi9606.ENSP00000347930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MIR4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 315261Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini337 – 35115CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi344 – 3496Poly-Asp

    Sequence similaritiesi

    Belongs to the CDC50/LEM3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5035.
    HOGENOMiHOG000209057.
    HOVERGENiHBG055537.
    InParanoidiQ3MIR4.
    OMAiRVNITYN.
    OrthoDBiEOG7C5M8D.
    PhylomeDBiQ3MIR4.
    TreeFamiTF300873.

    Family and domain databases

    InterProiIPR005045. DUF284_TM_euk.
    [Graphical view]
    PANTHERiPTHR10926. PTHR10926. 1 hit.
    PfamiPF03381. CDC50. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015840. DUF284_TM_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3MIR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWSATARGA HQPDNTAFTQ QRLPAWQPLL SASIALPLFF CAGLAFIGLG    50
    LGLYYSSNGI KELEYDYTGD PGTGNCSVCA AAGQGRALPP PCSCAWYFSL 100
    PELFQGPVYL YYELTNFYQN NRRYGVSRDD AQLSGLPSAL RHPVNECAPY 150
    QRSAAGLPIA PCGAIANSLF NDSFSLWHQR QPGGPYVEVP LDRSGIAWWT 200
    DYHVKFRNPP LVNGSLALAF QGTAPPPNWR RPVYELSPDP NNTGFINQDF 250
    VVWMRTAALP TFRKLYARIR QGNYSAGLPR GAYRVNITYN YPVRAFGGHK 300
    LLIFSSISWM GGKNPFLGIA YLVVGSLCIL TGFVMLVVYI RYQDQDDDDE 350
    E 351
    Length:351
    Mass (Da):38,941
    Last modified:October 25, 2005 - v1
    Checksum:iB68C91A784E33A44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091169 mRNA. Translation: BAG52296.1.
    CH471061 Genomic DNA. Translation: EAW80799.1.
    BC101726 mRNA. Translation: AAI01727.1.
    BC113559 mRNA. Translation: AAI13560.1.
    CCDSiCCDS32093.1.
    RefSeqiNP_001017970.1. NM_001017970.2.
    UniGeneiHs.146180.

    Genome annotation databases

    EnsembliENST00000555868; ENSP00000450842; ENSG00000182107.
    GeneIDi161291.
    KEGGihsa:161291.
    UCSCiuc001xfl.3. human.

    Polymorphism databases

    DMDMi109819759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091169 mRNA. Translation: BAG52296.1 .
    CH471061 Genomic DNA. Translation: EAW80799.1 .
    BC101726 mRNA. Translation: AAI01727.1 .
    BC113559 mRNA. Translation: AAI13560.1 .
    CCDSi CCDS32093.1.
    RefSeqi NP_001017970.1. NM_001017970.2.
    UniGenei Hs.146180.

    3D structure databases

    ProteinModelPortali Q3MIR4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127780. 1 interaction.
    IntActi Q3MIR4. 3 interactions.
    MINTi MINT-5004611.
    STRINGi 9606.ENSP00000347930.

    Polymorphism databases

    DMDMi 109819759.

    Proteomic databases

    MaxQBi Q3MIR4.
    PaxDbi Q3MIR4.
    PRIDEi Q3MIR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000555868 ; ENSP00000450842 ; ENSG00000182107 .
    GeneIDi 161291.
    KEGGi hsa:161291.
    UCSCi uc001xfl.3. human.

    Organism-specific databases

    CTDi 161291.
    GeneCardsi GC14M061744.
    HGNCi HGNC:27254. TMEM30B.
    HPAi HPA043162.
    MIMi 611029. gene.
    neXtProti NX_Q3MIR4.
    PharmGKBi PA134993260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5035.
    HOGENOMi HOG000209057.
    HOVERGENi HBG055537.
    InParanoidi Q3MIR4.
    OMAi RVNITYN.
    OrthoDBi EOG7C5M8D.
    PhylomeDBi Q3MIR4.
    TreeFami TF300873.

    Miscellaneous databases

    GenomeRNAii 161291.
    NextBioi 88046.
    PROi Q3MIR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3MIR4.
    CleanExi HS_TMEM30B.
    Genevestigatori Q3MIR4.

    Family and domain databases

    InterProi IPR005045. DUF284_TM_euk.
    [Graphical view ]
    PANTHERi PTHR10926. PTHR10926. 1 hit.
    Pfami PF03381. CDC50. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015840. DUF284_TM_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.
    4. "Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico."
      Katoh Y., Katoh M.
      Oncol. Rep. 12:939-943(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."
      van der Velden L.M., Wichers C.G., van Breevoort A.E., Coleman J.A., Molday R.S., Berger R., Klomp L.W., van de Graaf S.F.
      J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATP8B1 AND ATP8B2.
    6. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."
      Bryde S., Hennrich H., Verhulst P.M., Devaux P.F., Lenoir G., Holthuis J.C.
      J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATP8A1; ATP8B1; ATP8B2 AND ATP8B4.
    7. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
      Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
      J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATP8B1.

    Entry informationi

    Entry nameiCC50B_HUMAN
    AccessioniPrimary (citable) accession number: Q3MIR4
    Secondary accession number(s): B3KR84, Q14D00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3