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Protein

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

Gene

ITPRIPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:27257. ITPRIPL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 435ExtracellularSequence analysis
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Topological domaini65 – 535471CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721117.

Polymorphism and mutation databases

BioMutaiITPRIPL2.
DMDMi121942822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 535497Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2PRO_0000336093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MIP1.
PRIDEiQ3MIP1.

PTM databases

iPTMnetiQ3MIP1.
PhosphoSiteiQ3MIP1.

Expressioni

Gene expression databases

BgeeiQ3MIP1.
CleanExiHS_ITPRIPL2.
ExpressionAtlasiQ3MIP1. baseline and differential.
GenevisibleiQ3MIP1. HS.

Organism-specific databases

HPAiHPA048621.

Interactioni

Protein-protein interaction databases

BioGridi127808. 4 interactions.
IntActiQ3MIP1. 4 interactions.
STRINGi9606.ENSP00000370849.

Structurei

3D structure databases

ProteinModelPortaliQ3MIP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi324 – 3307Poly-Pro

Sequence similaritiesi

Belongs to the ITPRIP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXY. Eukaryota.
ENOG4111FAS. LUCA.
GeneTreeiENSGT00530000063794.
HOGENOMiHOG000060320.
HOVERGENiHBG101210.
InParanoidiQ3MIP1.
OMAiVCALKAP.
PhylomeDBiQ3MIP1.
TreeFamiTF332277.

Family and domain databases

InterProiIPR024798. IP3R-int-like_2.
IPR026250. ITPRIP_fam.
IPR024810. Mab-21_dom.
[Graphical view]
PANTHERiPTHR10656:SF9. PTHR10656:SF9. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
PRINTSiPR02107. INOS145TPRIP.
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MIP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHYTLNLR VFWPLVTGLC TALVCLYHVL RGSGGARAEP ADGVDGGFPL
60 70 80 90 100
LKVAVLLLLS YVLLRCRHAV RQRFLPGSPR LEGHAAFSSR HFREPGLSIL
110 120 130 140 150
LESYYEHEVR LSPHVLGHSK AHVSRIVGEL VRAGRARGSP GLIPGGALAL
160 170 180 190 200
AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL RLPPLVALEP RSLGEEPALA
210 220 230 240 250
PAFRGCFLCA LKAPPSPSGA SGGHWLRDCK PFADAFCVDV RGRRHLSATL
260 270 280 290 300
VLRWFQSHLQ RSLATVRYSL EGRCRVTLTP GGLEQPPTLH ILPCRTDYGC
310 320 330 340 350
CRLSMAVRLI PAVHLGDGVF LVAPPPPPLP SAPLLELPEG LRAEALWGVN
360 370 380 390 400
TARQEQKLLS WLQERAAPGA CYLKCLQLLK ALRDLGARGL DSAAATQWGR
410 420 430 440 450
ILSSYVLKTV LLAVLLRKGA PGQGWDEEHL GRCLEELVQF LRDCLLRRHT
460 470 480 490 500
LFHCVLGPGG AAAEVGPLPK ALREAAPVDL LAAFDGHARE LAAARLLSTW
510 520 530
QRLPQLLRAY GGPRYLARCP PPRSQRTQGF LEGEP
Length:535
Mass (Da):58,446
Last modified:October 25, 2005 - v1
Checksum:i000E9D653FD16284
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371C → S.
Corresponds to variant rs8051801 [ dbSNP | Ensembl ].
VAR_043549
Natural varianti522 – 5221P → S.
Corresponds to variant rs11074362 [ dbSNP | Ensembl ].
VAR_043550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471186 Genomic DNA. Translation: EAW50272.1.
BC101749 mRNA. Translation: AAI01750.1.
BC101751 mRNA. Translation: AAI01752.1.
CCDSiCCDS32395.1.
RefSeqiNP_001030013.1. NM_001034841.3.
UniGeneiHs.530899.

Genome annotation databases

EnsembliENST00000381440; ENSP00000370849; ENSG00000205730.
GeneIDi162073.
KEGGihsa:162073.
UCSCiuc002dfu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471186 Genomic DNA. Translation: EAW50272.1.
BC101749 mRNA. Translation: AAI01750.1.
BC101751 mRNA. Translation: AAI01752.1.
CCDSiCCDS32395.1.
RefSeqiNP_001030013.1. NM_001034841.3.
UniGeneiHs.530899.

3D structure databases

ProteinModelPortaliQ3MIP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127808. 4 interactions.
IntActiQ3MIP1. 4 interactions.
STRINGi9606.ENSP00000370849.

PTM databases

iPTMnetiQ3MIP1.
PhosphoSiteiQ3MIP1.

Polymorphism and mutation databases

BioMutaiITPRIPL2.
DMDMi121942822.

Proteomic databases

PaxDbiQ3MIP1.
PRIDEiQ3MIP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381440; ENSP00000370849; ENSG00000205730.
GeneIDi162073.
KEGGihsa:162073.
UCSCiuc002dfu.5. human.

Organism-specific databases

CTDi162073.
GeneCardsiITPRIPL2.
HGNCiHGNC:27257. ITPRIPL2.
HPAiHPA048621.
neXtProtiNX_Q3MIP1.
PharmGKBiPA164721117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXY. Eukaryota.
ENOG4111FAS. LUCA.
GeneTreeiENSGT00530000063794.
HOGENOMiHOG000060320.
HOVERGENiHBG101210.
InParanoidiQ3MIP1.
OMAiVCALKAP.
PhylomeDBiQ3MIP1.
TreeFamiTF332277.

Miscellaneous databases

ChiTaRSiITPRIPL2. human.
GenomeRNAii162073.
NextBioi88134.
PROiQ3MIP1.

Gene expression databases

BgeeiQ3MIP1.
CleanExiHS_ITPRIPL2.
ExpressionAtlasiQ3MIP1. baseline and differential.
GenevisibleiQ3MIP1. HS.

Family and domain databases

InterProiIPR024798. IP3R-int-like_2.
IPR026250. ITPRIP_fam.
IPR024810. Mab-21_dom.
[Graphical view]
PANTHERiPTHR10656:SF9. PTHR10656:SF9. 1 hit.
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
PRINTSiPR02107. INOS145TPRIP.
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiIPIL2_HUMAN
AccessioniPrimary (citable) accession number: Q3MIP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 25, 2005
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.