Q3MIF4 (XYLB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylulose kinase
Short name=Xylulokinase
EC=2.7.1.17

Gene names

Name:

Xylb

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis By similarity.
Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW xylulose metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	Xylulose kinase		PRO_0000230988
Regions
	Nucleotide binding	441 – 442	2	ATP By similarity
Sites
	Binding site	99	1	Substrate By similarity
	Binding site	170	1	Substrate By similarity
	Binding site	280	1	Substrate By similarity
	Binding site	281	1	Substrate By similarity
	Binding site	355	1	ATP By similarity
	Binding site	445	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MIF4 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 39206405B8361CB4	FASTA	536	57,970
	10 20 30 40 50 60 MAERAGRRCC LGWDFSTQQV KVVAVDAELN VFYEDSVHFD RDLPEFGTQG GVHVHKDRLT 70 80 90 100 110 120 VTSPVLMWVQ ALDLILEKMK ASGFDFSQVL ALSGAGQQHG SVYWKTGASL ALSSLSPALL 130 140 150 160 170 180 LHQQLQACFS VSDCPIWMDS STTAQCHQLE AAVGGAQALS CLTGSRAYER FTGNQISKIF 190 200 210 220 230 240 QKNPEAYSNS ERISLVSSFA ASLFLGRYSP IDYSDGSGMN LLQIQEKVWS QACLDACAPH 250 260 270 280 290 300 LKEKLGSPVP SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDVAVSLG 310 320 330 340 350 360 TSDTLFLWLQ KPMPALEGHI FCNPVDARQY MALLCFKNGS LMREKIRDES ASCSWNKFSK 370 380 390 400 410 420 ALQSTEMGNN GNLGFYFDVM EITPEIIGCH RFNADNMEVS AFPGDVEIRA LVEGQFMAKR 430 440 450 460 470 480 IHAEGLGYRI MPKTKILATG GASHNKDILQ VLADVFGAPV YVIDTTSSAC VGSAYRAFHG 490 500 510 520 530 LAGGTGVAFS EVVKSAPQPS LAATPNPGAS QVYAALLPRY AELEQRILSK ARGPLE

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC101852 mRNA. Translation: AAI01853.1.
IPI	IPI00371141.
RefSeq	NP_001028876.1. NM_001033704.1.
UniGene	Rn.8732.
3D structure databases
ProteinModelPortal	Q3MIF4.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000019106.
Proteomic databases
PaxDb	Q3MIF4.
PRIDE	Q3MIF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	316067.
KEGG	rno:316067.
UCSC	RGD:1307372. rat.
Organism-specific databases
CTD	9942.
RGD	1307372. Xylb.
Phylogenomic databases
eggNOG	COG1070.
HOGENOM	HOG000174850.
HOVERGEN	HBG053124.
InParanoid	Q3MIF4.
KO	K00854.
OrthoDB	EOG4P5K94.
Gene expression databases
Genevestigator	Q3MIF4.
GermOnline	ENSRNOG00000014168. Rattus norvegicus.
Family and domain databases
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	670382.

Entry information

Entry name

XYLB_RAT

Accession

Primary (citable) accession number: Q3MIF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2005
Last modified:	May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program