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Protein

Xylulose kinase

Gene

Xylb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei280 – 2801SubstrateBy similarity
Binding sitei281 – 2811SubstrateBy similarity
Binding sitei355 – 3551ATPBy similarity
Binding sitei445 – 4451ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi441 – 4422ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. D-xylose metabolic process Source: UniProtKB-KW
  3. xylulose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:Xylb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1307372. Xylb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Xylulose kinasePRO_0000230988Add
BLAST

Proteomic databases

PaxDbiQ3MIF4.
PRIDEiQ3MIF4.

Expressioni

Gene expression databases

GenevestigatoriQ3MIF4.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019106.

Structurei

3D structure databases

ProteinModelPortaliQ3MIF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiQ3MIF4.
KOiK00854.
PhylomeDBiQ3MIF4.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MIF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERAGRRCC LGWDFSTQQV KVVAVDAELN VFYEDSVHFD RDLPEFGTQG
60 70 80 90 100
GVHVHKDRLT VTSPVLMWVQ ALDLILEKMK ASGFDFSQVL ALSGAGQQHG
110 120 130 140 150
SVYWKTGASL ALSSLSPALL LHQQLQACFS VSDCPIWMDS STTAQCHQLE
160 170 180 190 200
AAVGGAQALS CLTGSRAYER FTGNQISKIF QKNPEAYSNS ERISLVSSFA
210 220 230 240 250
ASLFLGRYSP IDYSDGSGMN LLQIQEKVWS QACLDACAPH LKEKLGSPVP
260 270 280 290 300
SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDVAVSLG
310 320 330 340 350
TSDTLFLWLQ KPMPALEGHI FCNPVDARQY MALLCFKNGS LMREKIRDES
360 370 380 390 400
ASCSWNKFSK ALQSTEMGNN GNLGFYFDVM EITPEIIGCH RFNADNMEVS
410 420 430 440 450
AFPGDVEIRA LVEGQFMAKR IHAEGLGYRI MPKTKILATG GASHNKDILQ
460 470 480 490 500
VLADVFGAPV YVIDTTSSAC VGSAYRAFHG LAGGTGVAFS EVVKSAPQPS
510 520 530
LAATPNPGAS QVYAALLPRY AELEQRILSK ARGPLE
Length:536
Mass (Da):57,970
Last modified:October 25, 2005 - v1
Checksum:i39206405B8361CB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101852 mRNA. Translation: AAI01853.1.
RefSeqiNP_001028876.1. NM_001033704.1.
UniGeneiRn.8732.

Genome annotation databases

GeneIDi316067.
KEGGirno:316067.
UCSCiRGD:1307372. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101852 mRNA. Translation: AAI01853.1.
RefSeqiNP_001028876.1. NM_001033704.1.
UniGeneiRn.8732.

3D structure databases

ProteinModelPortaliQ3MIF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019106.

Proteomic databases

PaxDbiQ3MIF4.
PRIDEiQ3MIF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316067.
KEGGirno:316067.
UCSCiRGD:1307372. rat.

Organism-specific databases

CTDi9942.
RGDi1307372. Xylb.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiQ3MIF4.
KOiK00854.
PhylomeDBiQ3MIF4.

Miscellaneous databases

NextBioi670382.
PROiQ3MIF4.

Gene expression databases

GenevestigatoriQ3MIF4.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiXYLB_RAT
AccessioniPrimary (citable) accession number: Q3MIF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.