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Q3MIF4

- XYLB_RAT

UniProt

Q3MIF4 - XYLB_RAT

Protein

Xylulose kinase

Gene

Xylb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.By similarity

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei280 – 2801SubstrateBy similarity
    Binding sitei281 – 2811SubstrateBy similarity
    Binding sitei355 – 3551ATPBy similarity
    Binding sitei445 – 4451ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi441 – 4422ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. D-xylose metabolic process Source: UniProtKB-KW
    3. xylulose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose kinase (EC:2.7.1.17)
    Short name:
    Xylulokinase
    Gene namesi
    Name:Xylb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1307372. Xylb.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Xylulose kinasePRO_0000230988Add
    BLAST

    Proteomic databases

    PaxDbiQ3MIF4.
    PRIDEiQ3MIF4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3MIF4.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000019106.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MIF4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000174850.
    HOVERGENiHBG053124.
    InParanoidiQ3MIF4.
    KOiK00854.
    PhylomeDBiQ3MIF4.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3MIF4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERAGRRCC LGWDFSTQQV KVVAVDAELN VFYEDSVHFD RDLPEFGTQG    50
    GVHVHKDRLT VTSPVLMWVQ ALDLILEKMK ASGFDFSQVL ALSGAGQQHG 100
    SVYWKTGASL ALSSLSPALL LHQQLQACFS VSDCPIWMDS STTAQCHQLE 150
    AAVGGAQALS CLTGSRAYER FTGNQISKIF QKNPEAYSNS ERISLVSSFA 200
    ASLFLGRYSP IDYSDGSGMN LLQIQEKVWS QACLDACAPH LKEKLGSPVP 250
    SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDVAVSLG 300
    TSDTLFLWLQ KPMPALEGHI FCNPVDARQY MALLCFKNGS LMREKIRDES 350
    ASCSWNKFSK ALQSTEMGNN GNLGFYFDVM EITPEIIGCH RFNADNMEVS 400
    AFPGDVEIRA LVEGQFMAKR IHAEGLGYRI MPKTKILATG GASHNKDILQ 450
    VLADVFGAPV YVIDTTSSAC VGSAYRAFHG LAGGTGVAFS EVVKSAPQPS 500
    LAATPNPGAS QVYAALLPRY AELEQRILSK ARGPLE 536
    Length:536
    Mass (Da):57,970
    Last modified:October 25, 2005 - v1
    Checksum:i39206405B8361CB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC101852 mRNA. Translation: AAI01853.1.
    RefSeqiNP_001028876.1. NM_001033704.1.
    UniGeneiRn.8732.

    Genome annotation databases

    GeneIDi316067.
    KEGGirno:316067.
    UCSCiRGD:1307372. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC101852 mRNA. Translation: AAI01853.1 .
    RefSeqi NP_001028876.1. NM_001033704.1.
    UniGenei Rn.8732.

    3D structure databases

    ProteinModelPortali Q3MIF4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000019106.

    Proteomic databases

    PaxDbi Q3MIF4.
    PRIDEi Q3MIF4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 316067.
    KEGGi rno:316067.
    UCSCi RGD:1307372. rat.

    Organism-specific databases

    CTDi 9942.
    RGDi 1307372. Xylb.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000174850.
    HOVERGENi HBG053124.
    InParanoidi Q3MIF4.
    KOi K00854.
    PhylomeDBi Q3MIF4.

    Miscellaneous databases

    NextBioi 670382.
    PROi Q3MIF4.

    Gene expression databases

    Genevestigatori Q3MIF4.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiXYLB_RAT
    AccessioniPrimary (citable) accession number: Q3MIF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3