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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3mbtl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3mbtl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1308569 L3mbtl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003467851 – 703Lethal(3)malignant brain tumor-like protein 2Add BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei681PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3MIF2
PRIDEiQ3MIF2

PTM databases

iPTMnetiQ3MIF2
PhosphoSitePlusiQ3MIF2

Expressioni

Gene expression databases

BgeeiENSRNOG00000024743
GenevisibleiQ3MIF2 RN

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031908

Structurei

3D structure databases

ProteinModelPortaliQ3MIF2
SMRiQ3MIF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 283MBT 1Add BLAST105
Repeati291 – 391MBT 2Add BLAST101
Repeati397 – 500MBT 3Add BLAST104
Repeati508 – 604MBT 4Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4
Compositional biasi620 – 624Poly-Lys5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KCPG Eukaryota
ENOG410ZYE4 LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000231220
HOVERGENiHBG057974
InParanoidiQ3MIF2
OMAiDGWDNEY
OrthoDBiEOG091G0312
PhylomeDBiQ3MIF2

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR038038 L3MBTL2
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PANTHERiPTHR12247:SF64 PTHR12247:SF64, 1 hit
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MIF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPRGTEET PSSEPMEEEE DDDLELFGGY DSFRSYNSSA GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LFSSANNRAL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHAQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVGCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIATVIQAAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKSYLMKR
310 320 330 340 350
LVGSRTLPAD FHIKMVESMK YPFRQGMRLE VVDKTQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SERRCDMSHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGNICVATI
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GSDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYETQPFDW ESYLEKTKSK AAPARLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDNEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVSAEPN TPQKGKDATK KKKKQFGKKR KRIPSAKTRP LRQSSKKPLL
660 670 680 690 700
EDNLEALGVS EPVPDDIIAV CVKEEHQDLP SPDRSPSPLL PLPTESIKQE

RDS
Length:703
Mass (Da):78,967
Last modified:October 25, 2005 - v1
Checksum:i6FFFE8B8B4BD88E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101865 mRNA Translation: AAI01866.1
RefSeqiNP_001028867.1, NM_001033695.1
UniGeneiRn.137566

Genome annotation databases

EnsembliENSRNOT00000034998; ENSRNOP00000031908; ENSRNOG00000024743
GeneIDi300320
KEGGirno:300320
UCSCiRGD:1308569 rat

Similar proteinsi

Entry informationi

Entry nameiLMBL2_RAT
AccessioniPrimary (citable) accession number: Q3MIF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health