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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3mbtl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3mbtl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1308569. L3mbtl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003467851 – 703Lethal(3)malignant brain tumor-like protein 2Add BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei681PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3MIF2.
PRIDEiQ3MIF2.

PTM databases

iPTMnetiQ3MIF2.
PhosphoSitePlusiQ3MIF2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024743.
GenevisibleiQ3MIF2. RN.

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031908.

Structurei

3D structure databases

ProteinModelPortaliQ3MIF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 283MBT 1Add BLAST105
Repeati291 – 391MBT 2Add BLAST101
Repeati397 – 500MBT 3Add BLAST104
Repeati508 – 604MBT 4Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4
Compositional biasi620 – 624Poly-Lys5

Sequence similaritiesi

Contains 1 FCS-type zinc finger.PROSITE-ProRule annotation
Contains 4 MBT repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KCPG. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231220.
HOVERGENiHBG057974.
InParanoidiQ3MIF2.
OMAiDGWDNEY.
OrthoDBiEOG091G0312.
PhylomeDBiQ3MIF2.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MIF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPRGTEET PSSEPMEEEE DDDLELFGGY DSFRSYNSSA GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LFSSANNRAL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHAQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVGCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIATVIQAAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKSYLMKR
310 320 330 340 350
LVGSRTLPAD FHIKMVESMK YPFRQGMRLE VVDKTQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SERRCDMSHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGNICVATI
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GSDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYETQPFDW ESYLEKTKSK AAPARLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDNEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVSAEPN TPQKGKDATK KKKKQFGKKR KRIPSAKTRP LRQSSKKPLL
660 670 680 690 700
EDNLEALGVS EPVPDDIIAV CVKEEHQDLP SPDRSPSPLL PLPTESIKQE

RDS
Length:703
Mass (Da):78,967
Last modified:October 25, 2005 - v1
Checksum:i6FFFE8B8B4BD88E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101865 mRNA. Translation: AAI01866.1.
RefSeqiNP_001028867.1. NM_001033695.1.
UniGeneiRn.137566.

Genome annotation databases

EnsembliENSRNOT00000034998; ENSRNOP00000031908; ENSRNOG00000024743.
GeneIDi300320.
KEGGirno:300320.
UCSCiRGD:1308569. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101865 mRNA. Translation: AAI01866.1.
RefSeqiNP_001028867.1. NM_001033695.1.
UniGeneiRn.137566.

3D structure databases

ProteinModelPortaliQ3MIF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031908.

PTM databases

iPTMnetiQ3MIF2.
PhosphoSitePlusiQ3MIF2.

Proteomic databases

PaxDbiQ3MIF2.
PRIDEiQ3MIF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034998; ENSRNOP00000031908; ENSRNOG00000024743.
GeneIDi300320.
KEGGirno:300320.
UCSCiRGD:1308569. rat.

Organism-specific databases

CTDi83746.
RGDi1308569. L3mbtl2.

Phylogenomic databases

eggNOGiENOG410KCPG. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231220.
HOVERGENiHBG057974.
InParanoidiQ3MIF2.
OMAiDGWDNEY.
OrthoDBiEOG091G0312.
PhylomeDBiQ3MIF2.

Miscellaneous databases

PROiQ3MIF2.

Gene expression databases

BgeeiENSRNOG00000024743.
GenevisibleiQ3MIF2. RN.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMBL2_RAT
AccessioniPrimary (citable) accession number: Q3MIF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.