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Protein

ADP-ribosylation factor GTPase-activating protein 2

Gene

Arfgap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4924C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 2
Short name:
ARF GAP 2
Alternative name(s):
GTPase-activating protein ZNF289
Zinc finger protein 289
Gene namesi
Name:Arfgap2
Synonyms:Zfp289, Znf289
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306177. Arfgap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 520519ADP-ribosylation factor GTPase-activating protein 2PRO_0000278471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei140 – 1401PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineCombined sources
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei236 – 2361PhosphoserineCombined sources
Modified residuei239 – 2391PhosphoserineCombined sources
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei339 – 3391PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineCombined sources
Modified residuei432 – 4321PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3MID3.
PRIDEiQ3MID3.

PTM databases

iPTMnetiQ3MID3.
PhosphoSiteiQ3MID3.

Expressioni

Gene expression databases

GenevisibleiQ3MID3. RN.

Interactioni

Subunit structurei

Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053988.

Structurei

3D structure databases

ProteinModelPortaliQ3MID3.
SMRiQ3MID3. Positions 5-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 127117Arf-GAPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 520424Required for interaction with coatomerBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili241 – 30767Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4924C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00390000005436.
HOGENOMiHOG000162970.
HOVERGENiHBG050563.
InParanoidiQ3MID3.
KOiK12493.
OMAiAHNCSST.
OrthoDBiEOG7B8S42.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MID3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGPSKSEI QTLFKRLRAI PTNKACFDCG AKSPSWASIT YGVFLCIDCS
60 70 80 90 100
GVHRSLGVHL SFIRSTELDS NWSWLQLRCM QVGGNANATA FFRQHGCLAN
110 120 130 140 150
DANTKYNSRA AQMYREKIRQ LGSTALARHG TDLWIDNMNS APSHSPEKKD
160 170 180 190 200
SDFFTEHTQA PAWDTAATDP SGTQQPALPS ESSSLAQPEP GPNTDLLGTS
210 220 230 240 250
PQASLELKSS IIGKKKPAAA KKGLGAKKGL GAQKVSNQSF TEIERQAQVA
260 270 280 290 300
EKLREQQAAD AKKQAEESMV ASMRLAYQEL QIDRKKEEKK LQNLEGKKRE
310 320 330 340 350
QAERLGMGLV SRSSISHSVL SEMQMIEQET PLSAKSSRSQ LDLFDDVGTF
360 370 380 390 400
ASGPPKYKDN PFSLGETFGS RWDSDAAWGM DRVEEKEPEV TISSIRPISE
410 420 430 440 450
RTTSRREVES RISGLESSEA RQKFAGAKAI SSDMFFGREV DSEYEARSRL
460 470 480 490 500
QQLSGSSAIS SSDLFGDVDG AHGGGTVSLG NVLPTADIAQ FKQGVKSVAG
510 520
KMAVLANGVM NSLQDRYGSY
Length:520
Mass (Da):56,556
Last modified:October 25, 2005 - v1
Checksum:i4F1E74D2593F1EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101917 mRNA. Translation: AAI01918.1.
RefSeqiNP_001028879.1. NM_001033707.1.
UniGeneiRn.3707.

Genome annotation databases

EnsembliENSRNOT00000057161; ENSRNOP00000053988; ENSRNOG00000014429.
GeneIDi362162.
KEGGirno:362162.
UCSCiRGD:1306177. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101917 mRNA. Translation: AAI01918.1.
RefSeqiNP_001028879.1. NM_001033707.1.
UniGeneiRn.3707.

3D structure databases

ProteinModelPortaliQ3MID3.
SMRiQ3MID3. Positions 5-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053988.

PTM databases

iPTMnetiQ3MID3.
PhosphoSiteiQ3MID3.

Proteomic databases

PaxDbiQ3MID3.
PRIDEiQ3MID3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057161; ENSRNOP00000053988; ENSRNOG00000014429.
GeneIDi362162.
KEGGirno:362162.
UCSCiRGD:1306177. rat.

Organism-specific databases

CTDi84364.
RGDi1306177. Arfgap2.

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00390000005436.
HOGENOMiHOG000162970.
HOVERGENiHBG050563.
InParanoidiQ3MID3.
KOiK12493.
OMAiAHNCSST.
OrthoDBiEOG7B8S42.

Enzyme and pathway databases

ReactomeiR-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ3MID3.

Gene expression databases

GenevisibleiQ3MID3. RN.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-236; SER-239; SER-339 AND SER-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARFG2_RAT
AccessioniPrimary (citable) accession number: Q3MID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 25, 2005
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.