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Protein

ADP-ribosylation factor GTPase-activating protein 2

Gene

Arfgap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 49C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 2
Short name:
ARF GAP 2
Alternative name(s):
GTPase-activating protein ZNF289
Zinc finger protein 289
Gene namesi
Name:Arfgap2
Synonyms:Zfp289, Znf289
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306177 Arfgap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002784712 – 520ADP-ribosylation factor GTPase-activating protein 2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei145PhosphoserineCombined sources1
Modified residuei200PhosphoserineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei311PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1
Modified residuei431PhosphoserineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei512PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3MID3
PRIDEiQ3MID3

PTM databases

iPTMnetiQ3MID3
PhosphoSitePlusiQ3MID3

Expressioni

Gene expression databases

BgeeiENSRNOG00000014429
GenevisibleiQ3MID3 RN

Interactioni

Subunit structurei

Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053988

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NZSelectron microscopy10.10P1-520[»]
ProteinModelPortaliQ3MID3
SMRiQ3MID3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 127Arf-GAPPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 520Required for interaction with coatomerBy similarityAdd BLAST424

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili241 – 307Sequence analysisAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 49C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0706 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00390000005436
HOGENOMiHOG000162970
HOVERGENiHBG050563
InParanoidiQ3MID3
KOiK12493
OMAiDQWQWDQ
OrthoDBiEOG091G0AS9

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MID3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGPSKSEI QTLFKRLRAI PTNKACFDCG AKSPSWASIT YGVFLCIDCS
60 70 80 90 100
GVHRSLGVHL SFIRSTELDS NWSWLQLRCM QVGGNANATA FFRQHGCLAN
110 120 130 140 150
DANTKYNSRA AQMYREKIRQ LGSTALARHG TDLWIDNMNS APSHSPEKKD
160 170 180 190 200
SDFFTEHTQA PAWDTAATDP SGTQQPALPS ESSSLAQPEP GPNTDLLGTS
210 220 230 240 250
PQASLELKSS IIGKKKPAAA KKGLGAKKGL GAQKVSNQSF TEIERQAQVA
260 270 280 290 300
EKLREQQAAD AKKQAEESMV ASMRLAYQEL QIDRKKEEKK LQNLEGKKRE
310 320 330 340 350
QAERLGMGLV SRSSISHSVL SEMQMIEQET PLSAKSSRSQ LDLFDDVGTF
360 370 380 390 400
ASGPPKYKDN PFSLGETFGS RWDSDAAWGM DRVEEKEPEV TISSIRPISE
410 420 430 440 450
RTTSRREVES RISGLESSEA RQKFAGAKAI SSDMFFGREV DSEYEARSRL
460 470 480 490 500
QQLSGSSAIS SSDLFGDVDG AHGGGTVSLG NVLPTADIAQ FKQGVKSVAG
510 520
KMAVLANGVM NSLQDRYGSY
Length:520
Mass (Da):56,556
Last modified:October 25, 2005 - v1
Checksum:i4F1E74D2593F1EA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101917 mRNA Translation: AAI01918.1
RefSeqiNP_001028879.1, NM_001033707.1
UniGeneiRn.3707

Genome annotation databases

EnsembliENSRNOT00000057161; ENSRNOP00000053988; ENSRNOG00000014429
GeneIDi362162
KEGGirno:362162
UCSCiRGD:1306177 rat

Similar proteinsi

Entry informationi

Entry nameiARFG2_RAT
AccessioniPrimary (citable) accession number: Q3MID3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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