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Protein

Lon protease homolog 2, peroxisomal

Gene

Lonp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei743UniRule annotation1
Active sitei786UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 2, peroxisomalUniRule annotation (EC:3.4.21.-UniRule annotation)
Alternative name(s):
Lon protease-like protein 2UniRule annotation
Short name:
Lon protease 2UniRule annotation
Peroxisomal Lon proteaseUniRule annotation
Gene namesi
Name:Lonp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305466. Lonp2.

Subcellular locationi

  • Peroxisome matrix UniRule annotation1 Publication

GO - Cellular componenti

  • membrane Source: Ensembl
  • nucleus Source: Ensembl
  • peroxisomal matrix Source: RGD
  • peroxisome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002876422 – 852Lon protease homolog 2, peroxisomalAdd BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3MIB4.
PRIDEiQ3MIB4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015162.
ExpressionAtlasiQ3MIB4. baseline and differential.
GenevisibleiQ3MIB4. RN.

Interactioni

Subunit structurei

Interacts with PEX5. Interacts with TYSND1.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020770.

Structurei

3D structure databases

ProteinModelPortaliQ3MIB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 220Lon N-terminalPROSITE-ProRule annotationAdd BLAST208
Domaini651 – 837Lon proteolyticPROSITE-ProRule annotationAdd BLAST187

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi850 – 852Microbody targeting signalUniRule annotation3

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
GeneTreeiENSGT00530000063553.
HOGENOMiHOG000261408.
HOVERGENiHBG000798.
InParanoidiQ3MIB4.
OMAiDNPHKKG.
PhylomeDBiQ3MIB4.
TreeFamiTF317215.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03121. lonp2_euk. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027501. Lonp2_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MIB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVNPIQIP SRLPLLLTHE SVLLPGSTMR TSVDTARNLQ LVRSRLLKGT
60 70 80 90 100
SLQSTILGVI PNTPDPASDS QDLPPLHRIG TAALAVQVVG SNWPKPHYTL
110 120 130 140 150
LITGLCRFQI VQVLKEKPYP VAEVEQLDRL EEFPNTCKTR EELGELSEQF
160 170 180 190 200
YRYSVQLVEM LDMSVPAVAK LRRLLDSLPR EALPDILTSI IRTSNKEKLQ
210 220 230 240 250
ILDAVSLEDR FKMTIPLLVR QIEGLKLLQK TRKPKQDDDK RVIAIRPIRR
260 270 280 290 300
ITHIPGALED EEEEEDNDDI VMLEKKIRTS SMPEQAHKVC VKEIKRLKKM
310 320 330 340 350
PQSMPEYALT RNYLELMVEL PWNKSTTDRL DIRAARILLD NDHYAMEKLK
360 370 380 390 400
RRVLEYLAVR QLKNNLKGPI LCFVGPPGVG KTSVGRSVAK TLGREFHRIA
410 420 430 440 450
LGGVCDQSDI RGHRRTYVGS MPGRIINGLK TVGVNNPVFL LDEVDKLGKS
460 470 480 490 500
LQGDPAAALL EVLDPEQNHN FTDHYLNVAF DLSQVLFIAT ANTTATIPPA
510 520 530 540 550
LLDRMEIIQV PGYTQEEKIE IAHRHLIPKQ LEQHGLTPQQ IQIPQLTTLA
560 570 580 590 600
IITRYTREAG VRSLDRKFGA ICRAVAVKVA EGQHKEAKLD RSDVADGEGC
610 620 630 640 650
KEHVLEDAKP ESIGDAADLA LPPEMPILID SHALKDILGP PLYELEVSER
660 670 680 690 700
LSQPGVAIGL AWTPLGGKIM FVEASRMDGE GQLTLTGQLG DVMKESAHLA
710 720 730 740 750
ISWLRSNAKK YHLTNAFGSF DLLDNTDIHL HFPAGAVTKD GPSAGVTIVT
760 770 780 790 800
CLASLFSGRL VRSDVAMTGE ITLRGLVLPV GGIKDKVLAA HRAGLKHIII
810 820 830 840 850
PQRNEKDLEE IPSNVKQDLS FVTASCLDEV LNAAFDGGFT VKTRPGLTDS

KL
Length:852
Mass (Da):94,393
Last modified:May 15, 2007 - v2
Checksum:iCB9D9D05F8D5E040
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113833 Genomic DNA. No translation available.
AABR03113838 Genomic DNA. No translation available.
AABR03114515 Genomic DNA. No translation available.
AABR03113506 Genomic DNA. No translation available.
BC103718 mRNA. Translation: AAI03719.1.
RefSeqiXP_006255300.1. XM_006255238.2.
UniGeneiRn.228635.

Genome annotation databases

EnsembliENSRNOT00000020770; ENSRNOP00000020770; ENSRNOG00000015162.
ENSRNOT00000087660; ENSRNOP00000069360; ENSRNOG00000015162.
GeneIDi291922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113833 Genomic DNA. No translation available.
AABR03113838 Genomic DNA. No translation available.
AABR03114515 Genomic DNA. No translation available.
AABR03113506 Genomic DNA. No translation available.
BC103718 mRNA. Translation: AAI03719.1.
RefSeqiXP_006255300.1. XM_006255238.2.
UniGeneiRn.228635.

3D structure databases

ProteinModelPortaliQ3MIB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020770.

Proteomic databases

PaxDbiQ3MIB4.
PRIDEiQ3MIB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020770; ENSRNOP00000020770; ENSRNOG00000015162.
ENSRNOT00000087660; ENSRNOP00000069360; ENSRNOG00000015162.
GeneIDi291922.

Organism-specific databases

CTDi83752.
RGDi1305466. Lonp2.

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
GeneTreeiENSGT00530000063553.
HOGENOMiHOG000261408.
HOVERGENiHBG000798.
InParanoidiQ3MIB4.
OMAiDNPHKKG.
PhylomeDBiQ3MIB4.
TreeFamiTF317215.

Miscellaneous databases

PROiQ3MIB4.

Gene expression databases

BgeeiENSRNOG00000015162.
ExpressionAtlasiQ3MIB4. baseline and differential.
GenevisibleiQ3MIB4. RN.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03121. lonp2_euk. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027501. Lonp2_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLONP2_RAT
AccessioniPrimary (citable) accession number: Q3MIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.