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Q3MIB4

- LONP2_RAT

UniProt

Q3MIB4 - LONP2_RAT

Protein

Lon protease homolog 2, peroxisomal

Gene

Lonp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei743 – 7431UniRule annotation
    Active sitei786 – 7861UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi375 – 3828ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ATP-dependent peptidase activity Source: RefGenome
    3. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. misfolded or incompletely synthesized protein catabolic process Source: RefGenome
    3. protein import into peroxisome matrix Source: UniProtKB-HAMAP
    4. protein processing Source: RefGenome
    5. protein targeting to peroxisome Source: RefGenome
    6. regulation of fatty acid beta-oxidation Source: Ensembl
    7. response to organic cyclic compound Source: RGD
    8. signal peptide processing Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Protein family/group databases

    MEROPSiS16.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lon protease homolog 2, peroxisomalUniRule annotation (EC:3.4.21.-UniRule annotation)
    Alternative name(s):
    Lon protease-like protein 2UniRule annotation
    Short name:
    Lon protease 2UniRule annotation
    Peroxisomal Lon proteaseUniRule annotation
    Gene namesi
    Name:Lonp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi1305466. Lonp2.

    Subcellular locationi

    Peroxisome matrix 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. nucleus Source: Ensembl
    2. peroxisomal matrix Source: RGD
    3. peroxisome Source: RGD

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 852851Lon protease homolog 2, peroxisomalPRO_0000287642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ3MIB4.
    PRIDEiQ3MIB4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3MIB4.

    Interactioni

    Subunit structurei

    Interacts with PEX5. Interacts with TYSND1.UniRule annotation

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MIB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 219207LonUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi850 – 8523Microbody targeting signalUniRule annotation

    Sequence similaritiesi

    Belongs to the peptidase S16 family.UniRule annotation
    Contains 1 Lon domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0466.
    GeneTreeiENSGT00530000063553.
    HOGENOMiHOG000261408.
    HOVERGENiHBG000798.
    InParanoidiQ3MIB4.
    KOiK01338.
    OMAiDQREYFL.
    OrthoDBiEOG77T13V.
    PhylomeDBiQ3MIB4.
    TreeFamiTF317215.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_03121. lonp2_euk.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027501. Lonp2_euk.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10046. PTHR10046. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001174. Lon_proteas. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00763. lon. 1 hit.
    PROSITEiPS01046. LON_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3MIB4-1 [UniParc]FASTAAdd to Basket

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    MSSVNPIQIP SRLPLLLTHE SVLLPGSTMR TSVDTARNLQ LVRSRLLKGT    50
    SLQSTILGVI PNTPDPASDS QDLPPLHRIG TAALAVQVVG SNWPKPHYTL 100
    LITGLCRFQI VQVLKEKPYP VAEVEQLDRL EEFPNTCKTR EELGELSEQF 150
    YRYSVQLVEM LDMSVPAVAK LRRLLDSLPR EALPDILTSI IRTSNKEKLQ 200
    ILDAVSLEDR FKMTIPLLVR QIEGLKLLQK TRKPKQDDDK RVIAIRPIRR 250
    ITHIPGALED EEEEEDNDDI VMLEKKIRTS SMPEQAHKVC VKEIKRLKKM 300
    PQSMPEYALT RNYLELMVEL PWNKSTTDRL DIRAARILLD NDHYAMEKLK 350
    RRVLEYLAVR QLKNNLKGPI LCFVGPPGVG KTSVGRSVAK TLGREFHRIA 400
    LGGVCDQSDI RGHRRTYVGS MPGRIINGLK TVGVNNPVFL LDEVDKLGKS 450
    LQGDPAAALL EVLDPEQNHN FTDHYLNVAF DLSQVLFIAT ANTTATIPPA 500
    LLDRMEIIQV PGYTQEEKIE IAHRHLIPKQ LEQHGLTPQQ IQIPQLTTLA 550
    IITRYTREAG VRSLDRKFGA ICRAVAVKVA EGQHKEAKLD RSDVADGEGC 600
    KEHVLEDAKP ESIGDAADLA LPPEMPILID SHALKDILGP PLYELEVSER 650
    LSQPGVAIGL AWTPLGGKIM FVEASRMDGE GQLTLTGQLG DVMKESAHLA 700
    ISWLRSNAKK YHLTNAFGSF DLLDNTDIHL HFPAGAVTKD GPSAGVTIVT 750
    CLASLFSGRL VRSDVAMTGE ITLRGLVLPV GGIKDKVLAA HRAGLKHIII 800
    PQRNEKDLEE IPSNVKQDLS FVTASCLDEV LNAAFDGGFT VKTRPGLTDS 850
    KL 852
    Length:852
    Mass (Da):94,393
    Last modified:May 15, 2007 - v2
    Checksum:iCB9D9D05F8D5E040
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03113833 Genomic DNA. No translation available.
    AABR03113838 Genomic DNA. No translation available.
    AABR03114515 Genomic DNA. No translation available.
    AABR03113506 Genomic DNA. No translation available.
    BC103718 mRNA. Translation: AAI03719.1.
    RefSeqiXP_006255300.1. XM_006255238.1.
    UniGeneiRn.228635.

    Genome annotation databases

    EnsembliENSRNOT00000020770; ENSRNOP00000020770; ENSRNOG00000015162.
    GeneIDi291922.
    KEGGirno:291922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03113833 Genomic DNA. No translation available.
    AABR03113838 Genomic DNA. No translation available.
    AABR03114515 Genomic DNA. No translation available.
    AABR03113506 Genomic DNA. No translation available.
    BC103718 mRNA. Translation: AAI03719.1 .
    RefSeqi XP_006255300.1. XM_006255238.1.
    UniGenei Rn.228635.

    3D structure databases

    ProteinModelPortali Q3MIB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020770.

    Protein family/group databases

    MEROPSi S16.006.

    Proteomic databases

    PaxDbi Q3MIB4.
    PRIDEi Q3MIB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020770 ; ENSRNOP00000020770 ; ENSRNOG00000015162 .
    GeneIDi 291922.
    KEGGi rno:291922.

    Organism-specific databases

    CTDi 83752.
    RGDi 1305466. Lonp2.

    Phylogenomic databases

    eggNOGi COG0466.
    GeneTreei ENSGT00530000063553.
    HOGENOMi HOG000261408.
    HOVERGENi HBG000798.
    InParanoidi Q3MIB4.
    KOi K01338.
    OMAi DQREYFL.
    OrthoDBi EOG77T13V.
    PhylomeDBi Q3MIB4.
    TreeFami TF317215.

    Miscellaneous databases

    PROi Q3MIB4.

    Gene expression databases

    Genevestigatori Q3MIB4.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_03121. lonp2_euk.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027501. Lonp2_euk.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10046. PTHR10046. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001174. Lon_proteas. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00763. lon. 1 hit.
    PROSITEi PS01046. LON_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-852.
      Tissue: Ovary.
    3. "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease."
      Kikuchi M., Hatano N., Yokota S., Shimozawa N., Imanaka T., Taniguchi H.
      J. Biol. Chem. 279:421-428(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLONP2_RAT
    AccessioniPrimary (citable) accession number: Q3MIB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3