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Q3MI05

- PPGB_BOVIN

UniProt

Q3MI05 - PPGB_BOVIN

Protein

Lysosomal protective protein

Gene

CTSA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771By similarity
    Active sitei399 – 3991By similarity
    Active sitei456 – 4561By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Enzyme and pathway databases

    ReactomeiREACT_204575. Glycosphingolipid metabolism.
    REACT_213420. Sialic acid metabolism.

    Protein family/group databases

    MEROPSiS10.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal protective protein (EC:3.4.16.5)
    Alternative name(s):
    Cathepsin A
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CTSA
    Synonyms:PPGB
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 479452Lysosomal protective proteinPRO_0000236219Add
    BLAST
    Chaini28 – 325298Lysosomal protective protein 32 kDa chainBy similarityPRO_0000236220Add
    BLAST
    Chaini326 – 479154Lysosomal protective protein 20 kDa chainBy similarityPRO_0000236221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi87 ↔ 361By similarity
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi239 ↔ 255By similarity
    Disulfide bondi240 ↔ 245By similarity
    Disulfide bondi280 ↔ 330By similarity
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ3MI05.

    Interactioni

    Subunit structurei

    Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MI05.
    SMRiQ3MI05. Positions 28-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    GeneTreeiENSGT00560000077221.
    HOGENOMiHOG000198295.
    HOVERGENiHBG053652.
    KOiK13289.
    OMAiFYYFIVS.
    OrthoDBiEOG7KQ21H.
    TreeFamiTF323769.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3MI05-1 [UniParc]FASTAAdd to Basket

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    MFRAALWPPV LLLLQLLLLA CAPGGEGAHD QDEIRFLPGL AKQPSFRQYS    50
    GYLKGSGSKR LHYWFVESQK DPKSSPVVLW LNGGPGCSSL DGLLTEHGPF 100
    LIQPDGVTLE YNPYSWNLIA NVLYLESPAG VGFSYSDDKS YATNDTEVAQ 150
    SNFEALKDFF CLFPEYKGNE LFLTGESYAG IYIPTLAVLV MQDPSMNLQG 200
    LAVGNGLSSY EQNDNSLVYF AYYHGLLGNR LWSSLQTHCC SQNQCNFHDN 250
    KEPECVANLQ EVSHIVASSG LNIYNLYAPC AGGVPSHVRH EKDTVVVQDL 300
    GNIFTRLPLK RVWHQTLLRS GEKVHLDPPC TNTTAASNYL NDPHVRKALH 350
    IPEQLPRWDL CNFLVNIQYR RLYQSMCSQY LKLLSAQKYR ILLYNGDVDM 400
    ACNFMGDEWF VDSLNQKMEV QRRPWLVDYG ESGEQIAGFV KEFSHIAFLT 450
    IKGAGHMVPT DKPQAALTMF SRFLNRQPY 479
    Length:479
    Mass (Da):53,980
    Last modified:October 25, 2005 - v1
    Checksum:iA37CC37D5C575FBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104495 mRNA. Translation: AAI04496.1.
    RefSeqiNP_001030403.1. NM_001035326.1.
    UniGeneiBt.21410.

    Genome annotation databases

    EnsembliENSBTAT00000039203; ENSBTAP00000039003; ENSBTAG00000027337.
    GeneIDi518169.
    KEGGibta:518169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104495 mRNA. Translation: AAI04496.1 .
    RefSeqi NP_001030403.1. NM_001035326.1.
    UniGenei Bt.21410.

    3D structure databases

    ProteinModelPortali Q3MI05.
    SMRi Q3MI05. Positions 28-479.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.002.

    Proteomic databases

    PRIDEi Q3MI05.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000039203 ; ENSBTAP00000039003 ; ENSBTAG00000027337 .
    GeneIDi 518169.
    KEGGi bta:518169.

    Organism-specific databases

    CTDi 5476.

    Phylogenomic databases

    eggNOGi COG2939.
    GeneTreei ENSGT00560000077221.
    HOGENOMi HOG000198295.
    HOVERGENi HBG053652.
    KOi K13289.
    OMAi FYYFIVS.
    OrthoDBi EOG7KQ21H.
    TreeFami TF323769.

    Enzyme and pathway databases

    Reactomei REACT_204575. Glycosphingolipid metabolism.
    REACT_213420. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 20872600.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiPPGB_BOVIN
    AccessioniPrimary (citable) accession number: Q3MI05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3