Reviewed, UniProtKB/Swiss-Prot Q3MHX5 (SUCB2_BOVIN)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
    EC=6.2.1.4
Alternative name(s):
    GTP-specific succinyl-CoA synthetase subunit beta
    Succinyl-CoA synthetase beta-G chain
      Short name=SCS-betaG

Gene names

Name:

SUCLG2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	GTP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (GDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 37	37	Mitochondrion By similarity
	Chain	38 – 432	395	Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial		PRO_0000230989
Regions
	Domain	46 – 274	229	ATP-grasp

Sequences

	Sequence		Length	Mass (Da)
	Q3MHX5-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: C3A5343FF0A65B3D	FASTA	432	46,691
	10 20 30 40 50 60 MAAPVGAQAR KLLRDLVLRP PLLAARSQVV QLTSRRWLNL QEYQSKKLMS DNGVKVQRFF 70 80 90 100 110 120 VADTANEALE AAKRLNAKEI VLKAQILAGG RGKGVFSSGL KGGVHLTKDP KVVGQLAKQM 130 140 150 160 170 180 IGYNLATKQT PKEGVKVKKV MVAEALDISR ETYLAILMDR SCNGPVLVGS PQGGVDIEEV 190 200 210 220 230 240 AASNPELIFK EQIDIIEGIK DSQAQRMAEN LGFLGPLKNQ AADQIKKLYN LFLKIDATQV 250 260 270 280 290 300 EVNPFGETPE GQVVCFDAKI NFDDNAEFRQ KDIFAMDDKS ENEPIENEAA RYDLKYIGLD 310 320 330 340 350 360 GNIACFVNGA GLAMATCDII FLNGGKPANF LDLGGGVKES QVYQAFKLLT ADPKVEAILV 370 380 390 400 410 420 NIFGGIVNCA IIANGITKAC RELELKVPLV VRLEGTNVHE AQNILSNSGL PITSAVDLED 430 AAKKAVASVA KK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC104559 mRNA. Translation: AAI04560.1.
IPI	IPI00705618.
RefSeq	NP_001029811.1.
UniGene	Bt.23260
3D structure databases
SMR	Q3MHX5. Positions 38-429.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000009541. Bos taurus. [Contig view]
GeneID	537713.
KEGG	bta:537713.
Phylogenomic databases
HOVERGEN	Q3MHX5.
OMA	Q3MHX5. NEPINEA.
Enzyme and pathway databases
BRENDA	6.2.1.4. 251.
Family and domain databases
InterPro	IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. False negative. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCB2_BOVIN

Accession

Primary (citable) accession number: Q3MHX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)