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Protein

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-210991. Basigin interactions.
R-BTA-433692. Proton-coupled monocarboxylate transport.
R-BTA-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 1
Short name:
MCT 1
Alternative name(s):
Solute carrier family 16 member 1
Gene namesi
Name:SLC16A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 111ExtracellularSequence analysis4
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 143CytoplasmicSequence analysisAdd BLAST11
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 166ExtracellularSequence analysis2
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 262CytoplasmicSequence analysisAdd BLAST75
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 298ExtracellularSequence analysisAdd BLAST15
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 328CytoplasmicSequence analysis9
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 353ExtracellularSequence analysis4
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 389CytoplasmicSequence analysisAdd BLAST15
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 422ExtracellularSequence analysisAdd BLAST12
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 501CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871901 – 501Monocarboxylate transporter 1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei227PhosphoserineBy similarity1
Modified residuei231PhosphothreonineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei467PhosphothreonineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei499PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MHW6.
PeptideAtlasiQ3MHW6.
PRIDEiQ3MHW6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015107.

Interactioni

Subunit structurei

Interacts with BSG. Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020102.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVV. Eukaryota.
ENOG41116NW. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ3MHW6.
KOiK08179.
OMAiHMLAPLS.
OrthoDBiEOG091G05SW.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030757. MCT1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF24. PTHR11360:SF24. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FNATTSEVSW ISSIMLAVMY GGGPISSVLV NKYGSRPVMI VGGILSGSGL
110 120 130 140 150
IAASFCNTVQ ELYFSVGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLST LAPLNQAFFM IYGWRGSFLI LGGLLLNCCV AGALMRPIGP
210 220 230 240 250
KPTTAEKEKS KGSLQEAGKY ETKKGASDAN TDLIGGNPKE EKKSIFQTLN
260 270 280 290 300
TFLDLSLFKH RGFLLYLSGN VLMFFGLFTP LVFLSNYGKS KHYSSEKAAF
310 320 330 340 350
LLSILAFVDM VARPSMGLVA NTKWVRPRVQ YFFAASIIAN GLCHLAAPLS
360 370 380 390 400
STYIELCIYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC
410 420 430 440 450
PVLLGPPVLG RLNDIYGDYK YTYWACGIIL IVAGIYLFIG MGINYRLLEK
460 470 480 490 500
EQKAEKQQKK ESKDEETNVD VAEKPKEVID AAESPEHKAT EEDPKEAESP

V
Length:501
Mass (Da):54,297
Last modified:November 22, 2005 - v2
Checksum:i140F7F091CCC3C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104598 mRNA. Translation: AAI04599.2.
RefSeqiNP_001032396.1. NM_001037319.1.
XP_015319143.1. XM_015463657.1.
UniGeneiBt.40113.

Genome annotation databases

EnsembliENSBTAT00000020102; ENSBTAP00000020102; ENSBTAG00000015107.
GeneIDi505775.
KEGGibta:505775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104598 mRNA. Translation: AAI04599.2.
RefSeqiNP_001032396.1. NM_001037319.1.
XP_015319143.1. XM_015463657.1.
UniGeneiBt.40113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020102.

Proteomic databases

PaxDbiQ3MHW6.
PeptideAtlasiQ3MHW6.
PRIDEiQ3MHW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020102; ENSBTAP00000020102; ENSBTAG00000015107.
GeneIDi505775.
KEGGibta:505775.

Organism-specific databases

CTDi6566.

Phylogenomic databases

eggNOGiENOG410IMVV. Eukaryota.
ENOG41116NW. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ3MHW6.
KOiK08179.
OMAiHMLAPLS.
OrthoDBiEOG091G05SW.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-BTA-210991. Basigin interactions.
R-BTA-433692. Proton-coupled monocarboxylate transport.
R-BTA-70268. Pyruvate metabolism.

Gene expression databases

BgeeiENSBTAG00000015107.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030757. MCT1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF24. PTHR11360:SF24. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT1_BOVIN
AccessioniPrimary (citable) accession number: Q3MHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 22, 2005
Last modified: October 5, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.