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Protein

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-210991. Basigin interactions.
R-BTA-433692. Proton-coupled monocarboxylate transport.
R-BTA-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 1
Short name:
MCT 1
Alternative name(s):
Solute carrier family 16 member 1
Gene namesi
Name:SLC16A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 5923ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence analysis
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 1114ExtracellularSequence analysis
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Topological domaini133 – 14311CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 1662ExtracellularSequence analysis
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 26275CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 29815ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 3289CytoplasmicSequence analysis
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Topological domaini350 – 3534ExtracellularSequence analysis
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST
Topological domaini375 – 38915CytoplasmicSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST
Topological domaini411 – 42212ExtracellularSequence analysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST
Topological domaini444 – 50158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Monocarboxylate transporter 1PRO_0000287190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei213 – 2131PhosphoserineBy similarity
Modified residuei227 – 2271PhosphoserineBy similarity
Modified residuei231 – 2311PhosphothreonineBy similarity
Modified residuei462 – 4621PhosphoserineBy similarity
Modified residuei467 – 4671PhosphothreonineBy similarity
Modified residuei484 – 4841PhosphoserineBy similarity
Modified residuei499 – 4991PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MHW6.
PRIDEiQ3MHW6.

Interactioni

Subunit structurei

Interacts with BSG. Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020102.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVV. Eukaryota.
ENOG41116NW. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ3MHW6.
KOiK08179.
OMAiHMLAPLS.
OrthoDBiEOG7W9RTN.
TreeFamiTF313792.

Family and domain databases

InterProiIPR004743. MCT.
IPR030757. MCT1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF24. PTHR11360:SF24. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FNATTSEVSW ISSIMLAVMY GGGPISSVLV NKYGSRPVMI VGGILSGSGL
110 120 130 140 150
IAASFCNTVQ ELYFSVGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLST LAPLNQAFFM IYGWRGSFLI LGGLLLNCCV AGALMRPIGP
210 220 230 240 250
KPTTAEKEKS KGSLQEAGKY ETKKGASDAN TDLIGGNPKE EKKSIFQTLN
260 270 280 290 300
TFLDLSLFKH RGFLLYLSGN VLMFFGLFTP LVFLSNYGKS KHYSSEKAAF
310 320 330 340 350
LLSILAFVDM VARPSMGLVA NTKWVRPRVQ YFFAASIIAN GLCHLAAPLS
360 370 380 390 400
STYIELCIYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC
410 420 430 440 450
PVLLGPPVLG RLNDIYGDYK YTYWACGIIL IVAGIYLFIG MGINYRLLEK
460 470 480 490 500
EQKAEKQQKK ESKDEETNVD VAEKPKEVID AAESPEHKAT EEDPKEAESP

V
Length:501
Mass (Da):54,297
Last modified:November 22, 2005 - v2
Checksum:i140F7F091CCC3C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104598 mRNA. Translation: AAI04599.2.
RefSeqiNP_001032396.1. NM_001037319.1.
XP_015319143.1. XM_015463657.1.
UniGeneiBt.40113.

Genome annotation databases

EnsembliENSBTAT00000020102; ENSBTAP00000020102; ENSBTAG00000015107.
GeneIDi505775.
KEGGibta:505775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104598 mRNA. Translation: AAI04599.2.
RefSeqiNP_001032396.1. NM_001037319.1.
XP_015319143.1. XM_015463657.1.
UniGeneiBt.40113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020102.

Proteomic databases

PaxDbiQ3MHW6.
PRIDEiQ3MHW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020102; ENSBTAP00000020102; ENSBTAG00000015107.
GeneIDi505775.
KEGGibta:505775.

Organism-specific databases

CTDi6566.

Phylogenomic databases

eggNOGiENOG410IMVV. Eukaryota.
ENOG41116NW. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ3MHW6.
KOiK08179.
OMAiHMLAPLS.
OrthoDBiEOG7W9RTN.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-BTA-210991. Basigin interactions.
R-BTA-433692. Proton-coupled monocarboxylate transport.
R-BTA-70268. Pyruvate metabolism.

Miscellaneous databases

NextBioi20867305.

Family and domain databases

InterProiIPR004743. MCT.
IPR030757. MCT1.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF24. PTHR11360:SF24. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiMOT1_BOVIN
AccessioniPrimary (citable) accession number: Q3MHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 22, 2005
Last modified: May 11, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.