Reviewed,
UniProtKB/Swiss-Prot Q3MHT4 (TUT1_RAT)
Last modified
June 16, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: U6 snRNA-specific terminal uridylyltransferase 1 Short name=U6-TUTase EC=2.7.7.52 Alternative name(s): RNA-binding motif protein 21 Short name=RNA-binding protein 21 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 866 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Highly specific terminal uridylyltransferase that exclusively accepts U6 snRNA as substrate. U6 snRNA is unique in that nucleotides are both added to and removed from its 3'-end. U6-TUTase is responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA By similarity. |
| Catalytic activity | UTP + RNA(n) = diphosphate + RNA(n+1). |
| Subcellular location | |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. |
| Sequence similarities | Contains 1 RRM (RNA recognition motif) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Ligand | RNA-binding |
| Molecular function | Nucleotidyltransferase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Cellular component | nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA uridylyltransferase activityInferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| BC104695 mRNA. Translation: AAI04696.1. | |
| IPI | IPI00371444. |
| RefSeq | NP_001029073.1. |
| UniGene | Rn.129389 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q3MHT4. |
Genome annotation databases | |
| Ensembl | ENSRNOG00000020047. Rattus norvegicus. [Contig view] |
| GeneID | 499314. |
| KEGG | rno:499314. |
| NMPDR | fig|10116.3.peg.3665. |
Organism-specific databases | |
| RGD | 1561043. Tut1. |
Phylogenomic databases | |
| HOVERGEN | Q3MHT4. |
| OMA | Q3MHT4. QGGTSKR. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.52. 248. |
Gene expression databases | |
| ArrayExpress | Q3MHT4. |
| GermOnline | ENSRNOG00000020047. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR002058. PAP_assoc. IPR000504. RRM_RNP1. IPR015880. Znf_C2H2-like. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. |
| Pfam | PF03828. PAP_assoc. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view] |
| SMART | SM00360. RRM. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view] |
| PROSITE | PS50102. RRM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 702524. |
Entry information
| Entry name | TUT1_RAT | ||||||||
| Accession | Primary (citable) accession number: Q3MHT4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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