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Q3MHS7

- Q3MHS7_RAT

UniProt

Q3MHS7 - Q3MHS7_RAT

Protein
Submitted name:

GDP-mannose 4, 6-dehydratase

Gene

Gmds

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GDP-mannose 4,6-dehydratase activity Source: UniProtKB
    2. NADP+ binding Source: UniProtKB

    GO - Biological processi

    1. 'de novo' GDP-L-fucose biosynthetic process Source: UniProtKB
    2. GDP-mannose metabolic process Source: UniProtKB
    3. Notch signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GDP-mannose 4, 6-dehydrataseImported
    Submitted name:
    Protein GmdsImported
    Submitted name:
    RCG44147Imported
    Gene namesi
    Name:GmdsImported
    ORF Names:rCG_44147Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1311008. Gmds.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ3MHS7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000023691.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1089.
    GeneTreeiENSGT00440000033640.
    HOGENOMiHOG000168003.
    HOVERGENiHBG000727.
    InParanoidiQ3MHS7.
    KOiK01711.
    OMAiFMHIGKT.
    OrthoDBiEOG7K6PV5.
    TreeFamiTF300682.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00955. GDP_Man_dehydratase.
    InterProiIPR001509. Epimerase_deHydtase.
    IPR006368. GDP_Man_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01370. Epimerase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01472. gmd. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3MHS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHAPASCRR YPGSGDGEMG KLRKVALITG ITGQDGSYLA EFLLEKGYEV    50
    HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV 100
    KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAIK TCGLINSVKF 150
    YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF 200
    AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG 250
    HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFM HIGKTIVWEG 300
    KNENEVGRCK ETGKIHVTVD LKYYRPTEVD FLQGDCSKAQ QKLNWKPRVA 350
    FDELVREMVQ ADVELMRTNP NA 372
    Length:372
    Mass (Da):42,095
    Last modified:October 25, 2005 - v1
    Checksum:i7C03643BBA45307D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06091243 Genomic DNA. No translation available.
    AABR06091244 Genomic DNA. No translation available.
    AABR06091245 Genomic DNA. No translation available.
    AABR06091246 Genomic DNA. No translation available.
    AABR06091247 Genomic DNA. No translation available.
    AABR06091248 Genomic DNA. No translation available.
    AABR06091249 Genomic DNA. No translation available.
    AABR06091250 Genomic DNA. No translation available.
    AABR06091251 Genomic DNA. No translation available.
    AABR06091252 Genomic DNA. No translation available.
    AABR06091253 Genomic DNA. No translation available.
    AABR06091254 Genomic DNA. No translation available.
    AABR06091255 Genomic DNA. No translation available.
    AABR06091256 Genomic DNA. No translation available.
    AABR06091257 Genomic DNA. No translation available.
    BC104708 mRNA. Translation: AAI04709.1.
    CH473977 Genomic DNA. Translation: EDL98349.1.
    RefSeqiNP_001034695.1. NM_001039606.1.
    UniGeneiRn.212995.

    Genome annotation databases

    EnsembliENSRNOT00000023691; ENSRNOP00000023691; ENSRNOG00000017605.
    GeneIDi291095.
    KEGGirno:291095.
    UCSCiRGD:1311008. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06091243 Genomic DNA. No translation available.
    AABR06091244 Genomic DNA. No translation available.
    AABR06091245 Genomic DNA. No translation available.
    AABR06091246 Genomic DNA. No translation available.
    AABR06091247 Genomic DNA. No translation available.
    AABR06091248 Genomic DNA. No translation available.
    AABR06091249 Genomic DNA. No translation available.
    AABR06091250 Genomic DNA. No translation available.
    AABR06091251 Genomic DNA. No translation available.
    AABR06091252 Genomic DNA. No translation available.
    AABR06091253 Genomic DNA. No translation available.
    AABR06091254 Genomic DNA. No translation available.
    AABR06091255 Genomic DNA. No translation available.
    AABR06091256 Genomic DNA. No translation available.
    AABR06091257 Genomic DNA. No translation available.
    BC104708 mRNA. Translation: AAI04709.1 .
    CH473977 Genomic DNA. Translation: EDL98349.1 .
    RefSeqi NP_001034695.1. NM_001039606.1.
    UniGenei Rn.212995.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000023691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023691 ; ENSRNOP00000023691 ; ENSRNOG00000017605 .
    GeneIDi 291095.
    KEGGi rno:291095.
    UCSCi RGD:1311008. rat.

    Organism-specific databases

    CTDi 2762.
    RGDi 1311008. Gmds.

    Phylogenomic databases

    eggNOGi COG1089.
    GeneTreei ENSGT00440000033640.
    HOGENOMi HOG000168003.
    HOVERGENi HBG000727.
    InParanoidi Q3MHS7.
    KOi K01711.
    OMAi FMHIGKT.
    OrthoDBi EOG7K6PV5.
    TreeFami TF300682.

    Miscellaneous databases

    NextBioi 632111.
    PROi Q3MHS7.

    Gene expression databases

    Genevestigatori Q3MHS7.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00955. GDP_Man_dehydratase.
    InterProi IPR001509. Epimerase_deHydtase.
    IPR006368. GDP_Man_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01370. Epimerase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01472. gmd. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ3MHS7_RAT
    AccessioniPrimary (citable) accession number: Q3MHS7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3