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Q3MHR7

- ARPC2_BOVIN

UniProt

Q3MHR7 - ARPC2_BOVIN

Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARPC2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament By similarity.By similarity

    GO - Biological processi

    1. regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 2/3 complex subunit 2
    Alternative name(s):
    Arp2/3 complex 34 kDa subunit
    Short name:
    p34-ARC
    Gene namesi
    Name:ARPC2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell projection By similarity. Cell junctionsynapsesynaptosome By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: Reactome
    4. neuron projection Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Actin-related protein 2/3 complex subunit 2PRO_0000246170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751N6-acetyllysineBy similarity
    Modified residuei295 – 2951N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ3MHR7.
    PRIDEiQ3MHR7.

    Interactioni

    Subunit structurei

    Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

    Protein-protein interaction databases

    DIPiDIP-29792N.
    IntActiQ3MHR7. 1 interaction.
    STRINGi9913.ENSBTAP00000013707.

    Structurei

    Secondary structure

    1
    300
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 2416
    Beta strandi32 – 376
    Turni38 – 403
    Beta strandi41 – 466
    Helixi48 – 503
    Beta strandi54 – 607
    Helixi64 – 685
    Turni69 – 713
    Helixi72 – 809
    Helixi81 – 833
    Beta strandi84 – 863
    Beta strandi92 – 987
    Helixi106 – 1149
    Helixi116 – 13419
    Beta strandi142 – 1476
    Beta strandi150 – 1567
    Beta strandi161 – 1688
    Helixi172 – 18615
    Helixi188 – 1903
    Beta strandi193 – 1953
    Beta strandi197 – 2048
    Helixi207 – 2093
    Turni210 – 2134
    Beta strandi220 – 2278
    Helixi229 – 2324
    Turni234 – 2363
    Helixi237 – 2448
    Helixi247 – 27832

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K8KX-ray2.00D1-300[»]
    1TYQX-ray2.55D1-300[»]
    1U2VX-ray2.55D1-300[»]
    2P9IX-ray2.46D1-300[»]
    2P9KX-ray2.59D1-300[»]
    2P9LX-ray2.65D1-300[»]
    2P9NX-ray2.85D1-300[»]
    2P9PX-ray2.90D1-300[»]
    2P9SX-ray2.68D1-300[»]
    2P9UX-ray2.75D1-300[»]
    3DXKX-ray2.70D1-300[»]
    3DXMX-ray2.85D1-300[»]
    3RSEX-ray2.65D1-300[»]
    3UKRX-ray2.48D1-300[»]
    3UKUX-ray2.75D1-300[»]
    3ULEX-ray2.50D1-300[»]
    4JD2X-ray3.08D1-300[»]
    ProteinModelPortaliQ3MHR7.
    SMRiQ3MHR7. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3MHR7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARPC2 family.Curated

    Phylogenomic databases

    eggNOGiNOG327379.
    GeneTreeiENSGT00390000016794.
    HOGENOMiHOG000212535.
    HOVERGENiHBG050580.
    InParanoidiQ3MHR7.
    KOiK05758.
    OMAiYFKFQEE.
    OrthoDBiEOG73JKVS.
    TreeFamiTF315006.

    Family and domain databases

    InterProiIPR007188. P34-arc.
    [Graphical view]
    PANTHERiPTHR12058. PTHR12058. 1 hit.
    PfamiPF04045. P34-Arc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3MHR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG    50
    DKTKVMVSIS LKFYKELQAH GADELLKRVY GSYLVNPESG YNVSLLYDLE 100
    NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE 150
    TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF 200
    SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY 250
    LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR 300
    Length:300
    Mass (Da):34,349
    Last modified:October 25, 2005 - v1
    Checksum:i60801D999BFBF947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105136 mRNA. Translation: AAI05137.1.
    RefSeqiNP_001029885.1. NM_001034713.2.
    UniGeneiBt.6846.

    Genome annotation databases

    EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
    GeneIDi540838.
    KEGGibta:540838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105136 mRNA. Translation: AAI05137.1 .
    RefSeqi NP_001029885.1. NM_001034713.2.
    UniGenei Bt.6846.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K8K X-ray 2.00 D 1-300 [» ]
    1TYQ X-ray 2.55 D 1-300 [» ]
    1U2V X-ray 2.55 D 1-300 [» ]
    2P9I X-ray 2.46 D 1-300 [» ]
    2P9K X-ray 2.59 D 1-300 [» ]
    2P9L X-ray 2.65 D 1-300 [» ]
    2P9N X-ray 2.85 D 1-300 [» ]
    2P9P X-ray 2.90 D 1-300 [» ]
    2P9S X-ray 2.68 D 1-300 [» ]
    2P9U X-ray 2.75 D 1-300 [» ]
    3DXK X-ray 2.70 D 1-300 [» ]
    3DXM X-ray 2.85 D 1-300 [» ]
    3RSE X-ray 2.65 D 1-300 [» ]
    3UKR X-ray 2.48 D 1-300 [» ]
    3UKU X-ray 2.75 D 1-300 [» ]
    3ULE X-ray 2.50 D 1-300 [» ]
    4JD2 X-ray 3.08 D 1-300 [» ]
    ProteinModelPortali Q3MHR7.
    SMRi Q3MHR7. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29792N.
    IntActi Q3MHR7. 1 interaction.
    STRINGi 9913.ENSBTAP00000013707.

    Proteomic databases

    PaxDbi Q3MHR7.
    PRIDEi Q3MHR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013707 ; ENSBTAP00000013707 ; ENSBTAG00000010386 .
    GeneIDi 540838.
    KEGGi bta:540838.

    Organism-specific databases

    CTDi 10109.

    Phylogenomic databases

    eggNOGi NOG327379.
    GeneTreei ENSGT00390000016794.
    HOGENOMi HOG000212535.
    HOVERGENi HBG050580.
    InParanoidi Q3MHR7.
    KOi K05758.
    OMAi YFKFQEE.
    OrthoDBi EOG73JKVS.
    TreeFami TF315006.

    Enzyme and pathway databases

    Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    EvolutionaryTracei Q3MHR7.
    NextBioi 20878864.

    Family and domain databases

    InterProi IPR007188. P34-arc.
    [Graphical view ]
    PANTHERi PTHR12058. PTHR12058. 1 hit.
    Pfami PF04045. P34-Arc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
    3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
      Nolen B.J., Littlefield R.S., Pollard T.D.
      Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

    Entry informationi

    Entry nameiARPC2_BOVIN
    AccessioniPrimary (citable) accession number: Q3MHR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3