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Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARPC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:ARPC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461701 – 300Actin-related protein 2/3 complex subunit 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-acetyllysineBy similarity1
Modified residuei295N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3MHR7.
PeptideAtlasiQ3MHR7.
PRIDEiQ3MHR7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010386.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29792N.
IntActiQ3MHR7. 1 interactor.
STRINGi9913.ENSBTAP00000013707.

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 24Combined sources16
Beta strandi32 – 37Combined sources6
Turni38 – 40Combined sources3
Beta strandi41 – 46Combined sources6
Helixi48 – 50Combined sources3
Beta strandi54 – 60Combined sources7
Helixi64 – 68Combined sources5
Turni69 – 71Combined sources3
Helixi72 – 80Combined sources9
Helixi81 – 83Combined sources3
Beta strandi84 – 86Combined sources3
Beta strandi92 – 98Combined sources7
Helixi106 – 114Combined sources9
Helixi116 – 134Combined sources19
Beta strandi142 – 147Combined sources6
Beta strandi150 – 156Combined sources7
Beta strandi161 – 168Combined sources8
Helixi172 – 186Combined sources15
Helixi188 – 190Combined sources3
Beta strandi193 – 195Combined sources3
Beta strandi197 – 204Combined sources8
Helixi207 – 209Combined sources3
Turni210 – 213Combined sources4
Beta strandi220 – 227Combined sources8
Helixi229 – 232Combined sources4
Turni234 – 236Combined sources3
Helixi237 – 244Combined sources8
Helixi247 – 278Combined sources32

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00D1-300[»]
1TYQX-ray2.55D1-300[»]
1U2VX-ray2.55D1-300[»]
2P9IX-ray2.46D1-300[»]
2P9KX-ray2.59D1-300[»]
2P9LX-ray2.65D1-300[»]
2P9NX-ray2.85D1-300[»]
2P9PX-ray2.90D1-300[»]
2P9SX-ray2.68D1-300[»]
2P9UX-ray2.75D1-300[»]
3DXKX-ray2.70D1-300[»]
3DXMX-ray2.85D1-300[»]
3RSEX-ray2.65D1-300[»]
3UKRX-ray2.48D1-300[»]
3UKUX-ray2.75D1-300[»]
3ULEX-ray2.50D1-300[»]
4JD2X-ray3.08D1-300[»]
4XEIX-ray3.87D1-300[»]
4XF2X-ray5.00D/W1-300[»]
ProteinModelPortaliQ3MHR7.
SMRiQ3MHR7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3MHR7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
GeneTreeiENSGT00390000016794.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiQ3MHR7.
KOiK05758.
OMAiFPRHFAN.
OrthoDBiEOG091G0BUH.
TreeFamiTF315006.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSYLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,349
Last modified:October 25, 2005 - v1
Checksum:i60801D999BFBF947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105136 mRNA. Translation: AAI05137.1.
RefSeqiNP_001029885.1. NM_001034713.2.
UniGeneiBt.6846.

Genome annotation databases

EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
GeneIDi540838.
KEGGibta:540838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105136 mRNA. Translation: AAI05137.1.
RefSeqiNP_001029885.1. NM_001034713.2.
UniGeneiBt.6846.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00D1-300[»]
1TYQX-ray2.55D1-300[»]
1U2VX-ray2.55D1-300[»]
2P9IX-ray2.46D1-300[»]
2P9KX-ray2.59D1-300[»]
2P9LX-ray2.65D1-300[»]
2P9NX-ray2.85D1-300[»]
2P9PX-ray2.90D1-300[»]
2P9SX-ray2.68D1-300[»]
2P9UX-ray2.75D1-300[»]
3DXKX-ray2.70D1-300[»]
3DXMX-ray2.85D1-300[»]
3RSEX-ray2.65D1-300[»]
3UKRX-ray2.48D1-300[»]
3UKUX-ray2.75D1-300[»]
3ULEX-ray2.50D1-300[»]
4JD2X-ray3.08D1-300[»]
4XEIX-ray3.87D1-300[»]
4XF2X-ray5.00D/W1-300[»]
ProteinModelPortaliQ3MHR7.
SMRiQ3MHR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29792N.
IntActiQ3MHR7. 1 interactor.
STRINGi9913.ENSBTAP00000013707.

Proteomic databases

PaxDbiQ3MHR7.
PeptideAtlasiQ3MHR7.
PRIDEiQ3MHR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
GeneIDi540838.
KEGGibta:540838.

Organism-specific databases

CTDi10109.

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
GeneTreeiENSGT00390000016794.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiQ3MHR7.
KOiK05758.
OMAiFPRHFAN.
OrthoDBiEOG091G0BUH.
TreeFamiTF315006.

Enzyme and pathway databases

ReactomeiR-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

EvolutionaryTraceiQ3MHR7.

Gene expression databases

BgeeiENSBTAG00000010386.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARPC2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.