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Q3MHR7

- ARPC2_BOVIN

UniProt

Q3MHR7 - ARPC2_BOVIN

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Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARPC2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Biological processi

  1. positive regulation of actin filament polymerization Source: Ensembl
  2. positive regulation of lamellipodium assembly Source: Ensembl
  3. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:ARPC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity. Cell junctionsynapsesynaptosome By similarity

GO - Cellular componenti

  1. cell leading edge Source: Ensembl
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: Reactome
  4. endosome Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. focal adhesion Source: Ensembl
  7. Golgi apparatus Source: Ensembl
  8. neuron projection Source: UniProtKB-KW
  9. plasma membrane Source: Ensembl
  10. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Actin-related protein 2/3 complex subunit 2PRO_0000246170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysineBy similarity
Modified residuei295 – 2951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3MHR7.
PRIDEiQ3MHR7.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

Protein-protein interaction databases

DIPiDIP-29792N.
IntActiQ3MHR7. 1 interaction.
STRINGi9913.ENSBTAP00000013707.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2416
Beta strandi32 – 376
Turni38 – 403
Beta strandi41 – 466
Helixi48 – 503
Beta strandi54 – 607
Helixi64 – 685
Turni69 – 713
Helixi72 – 809
Helixi81 – 833
Beta strandi84 – 863
Beta strandi92 – 987
Helixi106 – 1149
Helixi116 – 13419
Beta strandi142 – 1476
Beta strandi150 – 1567
Beta strandi161 – 1688
Helixi172 – 18615
Helixi188 – 1903
Beta strandi193 – 1953
Beta strandi197 – 2048
Helixi207 – 2093
Turni210 – 2134
Beta strandi220 – 2278
Helixi229 – 2324
Turni234 – 2363
Helixi237 – 2448
Helixi247 – 27832

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00D1-300[»]
1TYQX-ray2.55D1-300[»]
1U2VX-ray2.55D1-300[»]
2P9IX-ray2.46D1-300[»]
2P9KX-ray2.59D1-300[»]
2P9LX-ray2.65D1-300[»]
2P9NX-ray2.85D1-300[»]
2P9PX-ray2.90D1-300[»]
2P9SX-ray2.68D1-300[»]
2P9UX-ray2.75D1-300[»]
3DXKX-ray2.70D1-300[»]
3DXMX-ray2.85D1-300[»]
3RSEX-ray2.65D1-300[»]
3UKRX-ray2.48D1-300[»]
3UKUX-ray2.75D1-300[»]
3ULEX-ray2.50D1-300[»]
4JD2X-ray3.08D1-300[»]
ProteinModelPortaliQ3MHR7.
SMRiQ3MHR7. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3MHR7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiNOG327379.
GeneTreeiENSGT00390000016794.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiQ3MHR7.
KOiK05758.
OMAiYFKFQEE.
OrthoDBiEOG73JKVS.
TreeFamiTF315006.

Family and domain databases

InterProiIPR007188. P34-arc.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHR7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSYLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,349
Last modified:October 25, 2005 - v1
Checksum:i60801D999BFBF947
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105136 mRNA. Translation: AAI05137.1.
RefSeqiNP_001029885.1. NM_001034713.2.
UniGeneiBt.6846.

Genome annotation databases

EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
GeneIDi540838.
KEGGibta:540838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105136 mRNA. Translation: AAI05137.1 .
RefSeqi NP_001029885.1. NM_001034713.2.
UniGenei Bt.6846.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 D 1-300 [» ]
1TYQ X-ray 2.55 D 1-300 [» ]
1U2V X-ray 2.55 D 1-300 [» ]
2P9I X-ray 2.46 D 1-300 [» ]
2P9K X-ray 2.59 D 1-300 [» ]
2P9L X-ray 2.65 D 1-300 [» ]
2P9N X-ray 2.85 D 1-300 [» ]
2P9P X-ray 2.90 D 1-300 [» ]
2P9S X-ray 2.68 D 1-300 [» ]
2P9U X-ray 2.75 D 1-300 [» ]
3DXK X-ray 2.70 D 1-300 [» ]
3DXM X-ray 2.85 D 1-300 [» ]
3RSE X-ray 2.65 D 1-300 [» ]
3UKR X-ray 2.48 D 1-300 [» ]
3UKU X-ray 2.75 D 1-300 [» ]
3ULE X-ray 2.50 D 1-300 [» ]
4JD2 X-ray 3.08 D 1-300 [» ]
ProteinModelPortali Q3MHR7.
SMRi Q3MHR7. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29792N.
IntActi Q3MHR7. 1 interaction.
STRINGi 9913.ENSBTAP00000013707.

Proteomic databases

PaxDbi Q3MHR7.
PRIDEi Q3MHR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013707 ; ENSBTAP00000013707 ; ENSBTAG00000010386 .
GeneIDi 540838.
KEGGi bta:540838.

Organism-specific databases

CTDi 10109.

Phylogenomic databases

eggNOGi NOG327379.
GeneTreei ENSGT00390000016794.
HOGENOMi HOG000212535.
HOVERGENi HBG050580.
InParanoidi Q3MHR7.
KOi K05758.
OMAi YFKFQEE.
OrthoDBi EOG73JKVS.
TreeFami TF315006.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q3MHR7.
NextBioi 20878864.

Family and domain databases

InterProi IPR007188. P34-arc.
[Graphical view ]
PANTHERi PTHR12058. PTHR12058. 1 hit.
Pfami PF04045. P34-Arc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3