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Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARPC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: Ensembl

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: InterPro
  2. positive regulation of lamellipodium assembly Source: Ensembl
  3. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_307278. EPHB-mediated forward signaling.
REACT_319858. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:ARPC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 2

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity. Cell junctionsynapsesynaptosome By similarity

GO - Cellular componenti

  1. Arp2/3 protein complex Source: InterPro
  2. cell leading edge Source: Ensembl
  3. cytosol Source: Reactome
  4. endosome Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. focal adhesion Source: Ensembl
  7. Golgi apparatus Source: Ensembl
  8. neuron projection Source: UniProtKB-SubCell
  9. plasma membrane Source: Ensembl
  10. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Actin-related protein 2/3 complex subunit 2PRO_0000246170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysineBy similarity
Modified residuei295 – 2951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3MHR7.
PRIDEiQ3MHR7.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

Protein-protein interaction databases

DIPiDIP-29792N.
IntActiQ3MHR7. 1 interaction.
STRINGi9913.ENSBTAP00000013707.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2416Combined sources
Beta strandi32 – 376Combined sources
Turni38 – 403Combined sources
Beta strandi41 – 466Combined sources
Helixi48 – 503Combined sources
Beta strandi54 – 607Combined sources
Helixi64 – 685Combined sources
Turni69 – 713Combined sources
Helixi72 – 809Combined sources
Helixi81 – 833Combined sources
Beta strandi84 – 863Combined sources
Beta strandi92 – 987Combined sources
Helixi106 – 1149Combined sources
Helixi116 – 13419Combined sources
Beta strandi142 – 1476Combined sources
Beta strandi150 – 1567Combined sources
Beta strandi161 – 1688Combined sources
Helixi172 – 18615Combined sources
Helixi188 – 1903Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi197 – 2048Combined sources
Helixi207 – 2093Combined sources
Turni210 – 2134Combined sources
Beta strandi220 – 2278Combined sources
Helixi229 – 2324Combined sources
Turni234 – 2363Combined sources
Helixi237 – 2448Combined sources
Helixi247 – 27832Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00D1-300[»]
1TYQX-ray2.55D1-300[»]
1U2VX-ray2.55D1-300[»]
2P9IX-ray2.46D1-300[»]
2P9KX-ray2.59D1-300[»]
2P9LX-ray2.65D1-300[»]
2P9NX-ray2.85D1-300[»]
2P9PX-ray2.90D1-300[»]
2P9SX-ray2.68D1-300[»]
2P9UX-ray2.75D1-300[»]
3DXKX-ray2.70D1-300[»]
3DXMX-ray2.85D1-300[»]
3RSEX-ray2.65D1-300[»]
3UKRX-ray2.48D1-300[»]
3UKUX-ray2.75D1-300[»]
3ULEX-ray2.50D1-300[»]
4JD2X-ray3.08D1-300[»]
SMRiQ3MHR7. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3MHR7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiNOG327379.
GeneTreeiENSGT00390000016794.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiQ3MHR7.
KOiK05758.
OMAiVFIQEFV.
OrthoDBiEOG73JKVS.
TreeFamiTF315006.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSYLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,349
Last modified:October 25, 2005 - v1
Checksum:i60801D999BFBF947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105136 mRNA. Translation: AAI05137.1.
RefSeqiNP_001029885.1. NM_001034713.2.
UniGeneiBt.6846.

Genome annotation databases

EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
GeneIDi540838.
KEGGibta:540838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105136 mRNA. Translation: AAI05137.1.
RefSeqiNP_001029885.1. NM_001034713.2.
UniGeneiBt.6846.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00D1-300[»]
1TYQX-ray2.55D1-300[»]
1U2VX-ray2.55D1-300[»]
2P9IX-ray2.46D1-300[»]
2P9KX-ray2.59D1-300[»]
2P9LX-ray2.65D1-300[»]
2P9NX-ray2.85D1-300[»]
2P9PX-ray2.90D1-300[»]
2P9SX-ray2.68D1-300[»]
2P9UX-ray2.75D1-300[»]
3DXKX-ray2.70D1-300[»]
3DXMX-ray2.85D1-300[»]
3RSEX-ray2.65D1-300[»]
3UKRX-ray2.48D1-300[»]
3UKUX-ray2.75D1-300[»]
3ULEX-ray2.50D1-300[»]
4JD2X-ray3.08D1-300[»]
SMRiQ3MHR7. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29792N.
IntActiQ3MHR7. 1 interaction.
STRINGi9913.ENSBTAP00000013707.

Proteomic databases

PaxDbiQ3MHR7.
PRIDEiQ3MHR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013707; ENSBTAP00000013707; ENSBTAG00000010386.
GeneIDi540838.
KEGGibta:540838.

Organism-specific databases

CTDi10109.

Phylogenomic databases

eggNOGiNOG327379.
GeneTreeiENSGT00390000016794.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiQ3MHR7.
KOiK05758.
OMAiVFIQEFV.
OrthoDBiEOG73JKVS.
TreeFamiTF315006.

Enzyme and pathway databases

ReactomeiREACT_307278. EPHB-mediated forward signaling.
REACT_319858. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTraceiQ3MHR7.
NextBioi20878864.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2005
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.