ID   DCK_BOVIN               Reviewed;         260 AA.
AC   Q3MHR2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Deoxycytidine kinase;
DE            Short=dCK;
DE            EC=2.7.1.74;
GN   Name=DCK;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the phosphorylation of the
CC       deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and
CC       deoxyadenosine (dA) (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + deoxycytidine = NDP + dCMP.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
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DR   EMBL; BC105141; AAI05142.1; -; mRNA.
DR   IPI; IPI00715108; -.
DR   RefSeq; NP_001029745.1; -.
DR   UniGene; Bt.27090; -.
DR   SMR; Q3MHR2; 19-260.
DR   Ensembl; ENSBTAG00000012397; Bos taurus.
DR   GeneID; 530642; -.
DR   KEGG; bta:530642; -.
DR   HOVERGEN; Q3MHR2; -.
DR   OMA; Q3MHR2; HRTLKTN.
DR   BRENDA; 2.7.1.74; 251.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004137; F:deoxycytidine kinase activity; IEA:EC.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase, nucleoside, nucleotide and nucl...; IEA:InterPro.
DR   InterPro; IPR002624; Deoxynucleoside_kinase.
DR   PANTHER; PTHR10513; dNK; 1.
DR   Pfam; PF01712; dNK; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein;
KW   Transferase.
FT   CHAIN         1    260       Deoxycytidine kinase.
FT                                /FTId=PRO_0000295028.
FT   NP_BIND      28     35       ATP (Probable).
FT   MOD_RES       3      3       Phosphothreonine (By similarity).
FT   MOD_RES       8      8       Phosphoserine (By similarity).
FT   MOD_RES      11     11       Phosphoserine (By similarity).
FT   MOD_RES      15     15       Phosphoserine (By similarity).
FT   MOD_RES      74     74       Phosphoserine (By similarity).
SQ   SEQUENCE   260 AA;  30329 MW;  07EB33EA77A8F457 CRC64;
     MATPPKRSCP SPAASSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV VPEPVARWCN
     VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFTFQSYA CLSRIRAQLA ALNGKLKDAE
     KPVLFFERSV YSDRYIFASN LYESDCMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLRA
     TPEKCLNRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE
     DFKDKHDSLI EKVKDFLSTL
//