Reviewed, UniProtKB/Swiss-Prot Q3MHR2 (DCK_BOVIN)

Names and origin

Protein names

Recommended name:
    Deoxycytidine kinase
      Short name=dCK
    EC=2.7.1.74

Gene names

Name:

DCK

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) By similarity.
Catalytic activity	NTP + deoxycytidine = NDP + dCMP.
Subunit structure	Homodimer By similarity.
Subcellular location	Nucleus By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the DCK/DGK family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW deoxycytidine kinase activity Inferred from electronic annotation. Source: EC phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Deoxycytidine kinase		PRO_0000295028
Regions
	Nucleotide binding	28 – 35	8	ATP Probable
Amino acid modifications
	Modified residue	3	1	Phosphothreonine By similarity
	Modified residue	8	1	Phosphoserine By similarity
	Modified residue	11	1	Phosphoserine By similarity
	Modified residue	15	1	Phosphoserine By similarity
	Modified residue	74	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3MHR2-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 07EB33EA77A8F457	FASTA	260	30,329
	10 20 30 40 50 60 MATPPKRSCP SPAASSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV VPEPVARWCN 70 80 90 100 110 120 VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFTFQSYA CLSRIRAQLA ALNGKLKDAE 130 140 150 160 170 180 KPVLFFERSV YSDRYIFASN LYESDCMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLRA 190 200 210 220 230 240 TPEKCLNRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE 250 260 DFKDKHDSLI EKVKDFLSTL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC105141 mRNA. Translation: AAI05142.1.
IPI	IPI00715108.
RefSeq	NP_001029745.1.
UniGene	Bt.27090
3D structure databases
SMR	Q3MHR2. Positions 19-260.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000012397. Bos taurus. [Contig view]
GeneID	530642.
KEGG	bta:530642.
Phylogenomic databases
HOVERGEN	Q3MHR2.
OMA	Q3MHR2. HRTLKTN.
Enzyme and pathway databases
BRENDA	2.7.1.74. 251.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. [Graphical view]
PANTHER	PTHR10513. dNK. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCK_BOVIN

Accession

Primary (citable) accession number: Q3MHR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)