Reviewed,
UniProtKB/Swiss-Prot Q3MHR2 (DCK_BOVIN)
Last modified
June 16, 2009.
Version 29.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Deoxycytidine kinase Short name=dCK EC=2.7.1.74 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 260 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) By similarity. |
| Catalytic activity | NTP + deoxycytidine = NDP + dCMP. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Nucleus By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. |
| Sequence similarities | Belongs to the DCK/DGK family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW deoxycytidine kinase activityInferred from electronic annotation. Source: EC phosphotransferase activity, alcohol group as acceptorInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 260 | 260 | Deoxycytidine kinase | PRO_0000295028 | |||||
Regions | |||||||||
| Nucleotide binding | 28 – 35 | 8 | ATP Probable | ||||||
Amino acid modifications | |||||||||
| Modified residue | 3 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 8 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 11 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 74 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| BC105141 mRNA. Translation: AAI05142.1. | |
| IPI | IPI00715108. |
| RefSeq | NP_001029745.1. |
| UniGene | Bt.27090 |
3D structure databases | |
| SMR | Q3MHR2. Positions 19-260. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000012397. Bos taurus. [Contig view] |
| GeneID | 530642. |
| KEGG | bta:530642. |
Phylogenomic databases | |
| HOVERGEN | Q3MHR2. |
| OMA | Q3MHR2. HRTLKTN. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.74. 251. |
Family and domain databases | |
| InterPro | IPR002624. Deoxynucleoside_kinase. [Graphical view] |
| PANTHER | PTHR10513. dNK. 1 hit. |
| Pfam | PF01712. dNK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCK_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3MHR2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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