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Q3MHR2 (DCK_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxycytidine kinase
Short name=dCK
EC=2.7.1.74
Gene names
Name:DCK
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) By similarity.

Catalytic activity

NTP + deoxycytidine = NDP + dCMP.

Subunit structure

Homodimer By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1 By similarity.

Sequence similarities

Belongs to the DCK/DGK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Deoxycytidine kinase
PRO_0000295028

Regions

Nucleotide binding28 – 369ATP By similarity
Nucleotide binding188 – 1925ATP By similarity
Nucleotide binding240 – 2423ATP By similarity

Sites

Active site1271Proton acceptor Potential
Binding site531Substrate By similarity
Binding site861Substrate By similarity
Binding site971Substrate By similarity
Binding site1281Substrate By similarity
Binding site1331Substrate By similarity
Binding site1971Substrate By similarity

Amino acid modifications

Modified residue31Phosphothreonine By similarity
Modified residue81Phosphoserine By similarity
Modified residue111Phosphoserine; by CK1 By similarity
Modified residue151Phosphoserine; by CK1 By similarity
Modified residue161Phosphoserine By similarity
Modified residue351Phosphoserine By similarity
Modified residue631Phosphoserine By similarity
Modified residue721Phosphothreonine; by CK1 By similarity
Modified residue741Phosphoserine; by CK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MHR2 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 07EB33EA77A8F457

FASTA26030,329
        10         20         30         40         50         60 
MATPPKRSCP SPAASSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV VPEPVARWCN 

        70         80         90        100        110        120 
VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFTFQSYA CLSRIRAQLA ALNGKLKDAE 

       130        140        150        160        170        180 
KPVLFFERSV YSDRYIFASN LYESDCMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLRA 

       190        200        210        220        230        240 
TPEKCLNRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE 

       250        260 
DFKDKHDSLI EKVKDFLSTL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC105141 mRNA. Translation: AAI05142.1.
IPIIPI00715108.
RefSeqNP_001029745.1. NM_001034573.1.
UniGeneBt.27090.

3D structure databases

HSSPHSSP built from PDB template 2A30 based on UniProtKB P27707.
ProteinModelPortalQ3MHR2.
SMRQ3MHR2. Positions 19-260.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MHR2.

Proteomic databases

PRIDEQ3MHR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016449; ENSBTAP00000016449; ENSBTAG00000012397.
GeneID530642.
KEGGbta:530642.

Organism-specific databases

CTD1633.

Phylogenomic databases

eggNOGmaNOG11251.
GeneTreeENSGT00510000046588.
HOVERGENHBG006216.
InParanoidQ3MHR2.
OMAHRTLKTN.
OrthoDBEOG48WC2T.

Family and domain databases

InterProIPR002624. Deoxynucleoside_kinase.
[Graphical view]
KOK00893.
PANTHERPTHR10513. dNK. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000705. DNK. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCK_BOVIN
AccessionPrimary (citable) accession number: Q3MHR2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 25, 2005
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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