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Protein

Acyl-protein thioesterase 1

Gene

LYPLA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity).By similarity

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Charge relay systemBy similarity
Active sitei174 – 1741Charge relay systemBy similarity
Active sitei208 – 2081Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-203615. eNOS activation.

Protein family/group databases

ESTHERibovin-lypa1. LYsophospholipase_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-protein thioesterase 1 (EC:3.1.2.-)
Short name:
APT-1
Alternative name(s):
Lysophospholipase 1
Lysophospholipase I
Short name:
LPL-I
Short name:
LysoPLA I
Gene namesi
Name:LYPLA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Acyl-protein thioesterase 1PRO_0000238674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei224 – 2241N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3MHR0.
PRIDEiQ3MHR0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005558.

Structurei

3D structure databases

ProteinModelPortaliQ3MHR0.
SMRiQ3MHR0. Positions 6-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ3MHR0.
KOiK06128.
OMAiDAQEDEH.
OrthoDBiEOG7M0NSQ.
TreeFamiTF314619.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MHR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGNNMSAPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSAHIK
60 70 80 90 100
YICPHAPVMP VTLNMNMAMP SWFDIIGLSP DSLEDETGIK QAAENVKALI
110 120 130 140 150
DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA
160 170 180 190 200
SFPQGPIGGV NRDISILQCH GDLDPLVPLM FGSLTAEKLK TLVNPANVTF
210 220 230
RTYAGMMHSS CQQEMMDIKQ FIDKLLPPVD
Length:230
Mass (Da):24,596
Last modified:October 25, 2005 - v1
Checksum:iF79E380C17548A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105143 mRNA. Translation: AAI05144.1.
RefSeqiNP_001029860.1. NM_001034688.2.
UniGeneiBt.13850.

Genome annotation databases

EnsembliENSBTAT00000005558; ENSBTAP00000005558; ENSBTAG00000004243.
GeneIDi539992.
KEGGibta:539992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105143 mRNA. Translation: AAI05144.1.
RefSeqiNP_001029860.1. NM_001034688.2.
UniGeneiBt.13850.

3D structure databases

ProteinModelPortaliQ3MHR0.
SMRiQ3MHR0. Positions 6-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005558.

Protein family/group databases

ESTHERibovin-lypa1. LYsophospholipase_carboxylesterase.

Proteomic databases

PaxDbiQ3MHR0.
PRIDEiQ3MHR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005558; ENSBTAP00000005558; ENSBTAG00000004243.
GeneIDi539992.
KEGGibta:539992.

Organism-specific databases

CTDi10434.

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ3MHR0.
KOiK06128.
OMAiDAQEDEH.
OrthoDBiEOG7M0NSQ.
TreeFamiTF314619.

Enzyme and pathway databases

ReactomeiR-BTA-203615. eNOS activation.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiLYPA1_BOVIN
AccessioniPrimary (citable) accession number: Q3MHR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2005
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.