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Protein

Developmentally-regulated GTP-binding protein 1

Gene

DRG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78GTPPROSITE-ProRule annotation8
Nucleotide bindingi117 – 121GTPPROSITE-ProRule annotation5
Nucleotide bindingi248 – 251GTPPROSITE-ProRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 1
Short name:
DRG-1
Gene namesi
Name:DRG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasm By similarity

  • Note: The DRG1-DFRP2/ZC3H15 complex associates with polysomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002615872 – 367Developmentally-regulated GTP-binding protein 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei100Phosphothreonine; by STK16By similarity1

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with ZC3H15.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3MHP5.
PeptideAtlasiQ3MHP5.
PRIDEiQ3MHP5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008990.

Interactioni

Subunit structurei

Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011834.

Structurei

3D structure databases

ProteinModelPortaliQ3MHP5.
SMRiQ3MHP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 290OBG-type GPROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 16Required for interaction with STK16By similarityAdd BLAST15

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ3MHP5.
OMAiIENEMAR.
OrthoDBiEOG091G0A12.
TreeFamiTF105677.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MHP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG
60 70 80 90 100
GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD
160 170 180 190 200
VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL
210 220 230 240 250
DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI
260 270 280 290 300
DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG
310 320 330 340 350
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV
360
GKDHTLEDED VIQIVKK
Length:367
Mass (Da):40,542
Last modified:October 25, 2005 - v1
Checksum:i4A177EA7C8E23005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105158 mRNA. Translation: AAI05159.1.
RefSeqiNP_001029863.1. NM_001034691.1.
UniGeneiBt.26551.

Genome annotation databases

EnsembliENSBTAT00000011834; ENSBTAP00000011834; ENSBTAG00000008990.
GeneIDi540161.
KEGGibta:540161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105158 mRNA. Translation: AAI05159.1.
RefSeqiNP_001029863.1. NM_001034691.1.
UniGeneiBt.26551.

3D structure databases

ProteinModelPortaliQ3MHP5.
SMRiQ3MHP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011834.

Proteomic databases

PaxDbiQ3MHP5.
PeptideAtlasiQ3MHP5.
PRIDEiQ3MHP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011834; ENSBTAP00000011834; ENSBTAG00000008990.
GeneIDi540161.
KEGGibta:540161.

Organism-specific databases

CTDi4733.

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075013.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ3MHP5.
OMAiIENEMAR.
OrthoDBiEOG091G0A12.
TreeFamiTF105677.

Gene expression databases

BgeeiENSBTAG00000008990.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRG1_BOVIN
AccessioniPrimary (citable) accession number: Q3MHP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 25, 2005
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.