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Q3MHN0 (PSB6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-6

EC=3.4.25.1
Gene names
Name:PSMB6
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB9.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Propeptide2 – 3433Removed in mature form By similarity
PRO_0000239858
Chain35 – 239205Proteasome subunit beta type-6
PRO_0000239859

Sites

Active site351Nucleophile

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Secondary structure

.................................. 239
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q3MHN0 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 88BCDA9DF8D7FDAB

FASTA23925,542
        10         20         30         40         50         60 
MAATLVAARG TRPAPAWGPE AIAPDWENRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI 

        70         80         90        100        110        120 
ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM 

       130        140        150        160        170        180 
CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQPFA IGGSGSSYIY GYVDATYREG 

       190        200        210        220        230 
MTKEECLQFT ANALALAMER DGSSGGVIRL AAIAEPGVER QVLLGDQIPK FTIATLPPL 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[2]"The structure of the mammalian 20S proteasome at 2.75 A resolution."
Unno M., Mizushima T., Morimoto Y., Tomisugi Y., Tanaka K., Yasuoka N., Tsukihara T.
Structure 10:609-618(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 35-239 OF COMPLEX WITH 20S PROTEASOME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105176 mRNA. Translation: AAI05177.1.
RefSeqNP_001029541.1. NM_001034369.2.
UniGeneBt.2116.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IRUX-ray2.75H/V35-238[»]
ProteinModelPortalQ3MHN0.
SMRQ3MHN0. Positions 35-236.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000017816.

Protein family/group databases

MEROPST01.010.

Proteomic databases

PRIDEQ3MHN0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017816; ENSBTAP00000017816; ENSBTAG00000013390.
GeneID510069.
KEGGbta:510069.

Organism-specific databases

CTD5694.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00510000046484.
HOGENOMHOG000091079.
HOVERGENHBG000123.
InParanoidQ3MHN0.
KOK02738.
OMATSIMAVQ.
OrthoDBEOG79GT80.
TreeFamTF106221.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ3MHN0.
NextBio20869260.

Entry information

Entry namePSB6_BOVIN
AccessionPrimary (citable) accession number: Q3MHN0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 25, 2005
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references