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Protein

TSC22 domain family protein 1

Gene

TSC22D1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Gene namesi
Name:TSC22D1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144TSC22 domain family protein 1PRO_0000285808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MHL6.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025431.

Structurei

3D structure databases

ProteinModelPortaliQ3MHL6.
SMRiQ3MHL6. Positions 59-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 9822Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiENOG410IRQW. Eukaryota.
ENOG4111PNZ. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiQ3MHL6.
OMAiMKAQWCR.
OrthoDBiEOG7RZ5PT.
TreeFamiTF329224.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSSGASVVA
60 70 80 90 100
IDNKIEQAMD LVKSHLMYAV REEVEVLKEQ IKELIEKNSQ LEQENNLLKT
110 120 130 140
LASPEQLAQF QAQLQTGSPP ATTQPQGTTQ PPAQPASQGS GPTA
Length:144
Mass (Da):15,680
Last modified:October 25, 2005 - v1
Checksum:iB8AEF42657C50892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105192 mRNA. Translation: AAI05193.1.
RefSeqiNP_001029549.1. NM_001034377.1.
UniGeneiBt.10953.

Genome annotation databases

EnsembliENSBTAT00000025431; ENSBTAP00000025431; ENSBTAG00000047739.
GeneIDi510359.
KEGGibta:510359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105192 mRNA. Translation: AAI05193.1.
RefSeqiNP_001029549.1. NM_001034377.1.
UniGeneiBt.10953.

3D structure databases

ProteinModelPortaliQ3MHL6.
SMRiQ3MHL6. Positions 59-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025431.

Proteomic databases

PaxDbiQ3MHL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025431; ENSBTAP00000025431; ENSBTAG00000047739.
GeneIDi510359.
KEGGibta:510359.

Organism-specific databases

CTDi8848.

Phylogenomic databases

eggNOGiENOG410IRQW. Eukaryota.
ENOG4111PNZ. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiQ3MHL6.
OMAiMKAQWCR.
OrthoDBiEOG7RZ5PT.
TreeFamiTF329224.

Miscellaneous databases

NextBioi20869400.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiT22D1_BOVIN
AccessioniPrimary (citable) accession number: Q3MHL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 25, 2005
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.