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Q3MHH9

- ECM2_BOVIN

UniProt

Q3MHH9 - ECM2_BOVIN

Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Promotes matrix assembly and cell adhesiveness.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular matrix protein 2
    Gene namesi
    Name:ECM2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 680660Extracellular matrix protein 2PRO_0000287727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with numerous extracellular matrix proteins.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015726.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MHH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 15758VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini288 – 32538LRRNTAdd
    BLAST
    Repeati349 – 36921LRR 1Add
    BLAST
    Repeati375 – 39622LRR 2Add
    BLAST
    Repeati397 – 41721LRR 3Add
    BLAST
    Repeati420 – 44021LRR 4Add
    BLAST
    Repeati446 – 46621LRR 5Add
    BLAST
    Repeati467 – 48822LRR 6Add
    BLAST
    Repeati491 – 51121LRR 7Add
    BLAST
    Repeati517 – 53822LRR 8Add
    BLAST
    Repeati539 – 55921LRR 9Add
    BLAST
    Repeati563 – 58321LRR 10Add
    BLAST
    Repeati590 – 61122LRR 11Add
    BLAST
    Repeati613 – 63422LRR 12Add
    BLAST
    Repeati642 – 66524LRR 13Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi275 – 2773Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi177 – 27296Glu-richAdd
    BLAST
    Compositional biasi252 – 27120Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 13 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000112319.
    HOVERGENiHBG031529.
    InParanoidiQ3MHH9.
    KOiK08119.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 3 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 13 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3MHH9-1 [UniParc]FASTAAdd to Basket

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    MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR    50
    QPGIQQMKTV TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG 100
    HCLANGMIMY NKAVWSPEPC TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG 150
    ECCPVCSNTE QREPTNLPHK QQSPPWEEMN RALRKEELQL EEDEEEVKQD 200
    ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH QHRNPARENE 250
    EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM 300
    CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL 350
    ERLDLSKNNI TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL 400
    KINENKLQVI DEESLSDLNQ LVTLELEGNN LSETNVNSLA FKPLKSLSYL 450
    RLGRNKFRII PQGLPASIEE LYLENNQIEE ITEISFNHTR KINVIGLRYN 500
    KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV HLVLIGNQIE 550
    RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE 600
    LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN 650
    NYIKTREIPS YAFSCIRSYS SIVLKPQNIK 680
    Length:680
    Mass (Da):78,062
    Last modified:October 25, 2005 - v1
    Checksum:i19D971D3301540EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105232 mRNA. Translation: AAI05233.1.
    RefSeqiNP_001029769.1. NM_001034597.1.
    UniGeneiBt.42321.

    Genome annotation databases

    GeneIDi533916.
    KEGGibta:533916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105232 mRNA. Translation: AAI05233.1 .
    RefSeqi NP_001029769.1. NM_001034597.1.
    UniGenei Bt.42321.

    3D structure databases

    ProteinModelPortali Q3MHH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015726.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 533916.
    KEGGi bta:533916.

    Organism-specific databases

    CTDi 1842.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000112319.
    HOVERGENi HBG031529.
    InParanoidi Q3MHH9.
    KOi K08119.

    Miscellaneous databases

    NextBioi 20876193.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 3 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 13 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.

    Entry informationi

    Entry nameiECM2_BOVIN
    AccessioniPrimary (citable) accession number: Q3MHH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3