Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Gene namesi
Name:ECM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000028772721 – 680Extracellular matrix protein 2Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Glycosylationi430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3MHH9.
PRIDEiQ3MHH9.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015726.

Structurei

3D structure databases

ProteinModelPortaliQ3MHH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 157VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini288 – 325LRRNTAdd BLAST38
Repeati349 – 369LRR 1Add BLAST21
Repeati375 – 396LRR 2Add BLAST22
Repeati397 – 417LRR 3Add BLAST21
Repeati420 – 440LRR 4Add BLAST21
Repeati446 – 466LRR 5Add BLAST21
Repeati467 – 488LRR 6Add BLAST22
Repeati491 – 511LRR 7Add BLAST21
Repeati517 – 538LRR 8Add BLAST22
Repeati539 – 559LRR 9Add BLAST21
Repeati563 – 583LRR 10Add BLAST21
Repeati590 – 611LRR 11Add BLAST22
Repeati613 – 634LRR 12Add BLAST22
Repeati642 – 665LRR 13Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi275 – 277Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 272Glu-richAdd BLAST96
Compositional biasi252 – 271Asp-richAdd BLAST20

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ3MHH9.
KOiK08119.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MHH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR
60 70 80 90 100
QPGIQQMKTV TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG
110 120 130 140 150
HCLANGMIMY NKAVWSPEPC TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG
160 170 180 190 200
ECCPVCSNTE QREPTNLPHK QQSPPWEEMN RALRKEELQL EEDEEEVKQD
210 220 230 240 250
ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH QHRNPARENE
260 270 280 290 300
EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM
310 320 330 340 350
CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL
360 370 380 390 400
ERLDLSKNNI TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL
410 420 430 440 450
KINENKLQVI DEESLSDLNQ LVTLELEGNN LSETNVNSLA FKPLKSLSYL
460 470 480 490 500
RLGRNKFRII PQGLPASIEE LYLENNQIEE ITEISFNHTR KINVIGLRYN
510 520 530 540 550
KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV HLVLIGNQIE
560 570 580 590 600
RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE
610 620 630 640 650
LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN
660 670 680
NYIKTREIPS YAFSCIRSYS SIVLKPQNIK
Length:680
Mass (Da):78,062
Last modified:October 25, 2005 - v1
Checksum:i19D971D3301540EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105232 mRNA. Translation: AAI05233.1.
RefSeqiNP_001029769.1. NM_001034597.1.
UniGeneiBt.42321.

Genome annotation databases

GeneIDi533916.
KEGGibta:533916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105232 mRNA. Translation: AAI05233.1.
RefSeqiNP_001029769.1. NM_001034597.1.
UniGeneiBt.42321.

3D structure databases

ProteinModelPortaliQ3MHH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015726.

Proteomic databases

PaxDbiQ3MHH9.
PRIDEiQ3MHH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi533916.
KEGGibta:533916.

Organism-specific databases

CTDi1842.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ3MHH9.
KOiK08119.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECM2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 25, 2005
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.