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Q3MHH9

- ECM2_BOVIN

UniProt

Q3MHH9 - ECM2_BOVIN

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Protein
Extracellular matrix protein 2
Gene
ECM2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Gene namesi
Name:ECM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 680660Extracellular matrix protein 2
PRO_0000287727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015726.

Structurei

3D structure databases

ProteinModelPortaliQ3MHH9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 15758VWFC
Add
BLAST
Domaini288 – 32538LRRNT
Add
BLAST
Repeati349 – 36921LRR 1
Add
BLAST
Repeati375 – 39622LRR 2
Add
BLAST
Repeati397 – 41721LRR 3
Add
BLAST
Repeati420 – 44021LRR 4
Add
BLAST
Repeati446 – 46621LRR 5
Add
BLAST
Repeati467 – 48822LRR 6
Add
BLAST
Repeati491 – 51121LRR 7
Add
BLAST
Repeati517 – 53822LRR 8
Add
BLAST
Repeati539 – 55921LRR 9
Add
BLAST
Repeati563 – 58321LRR 10
Add
BLAST
Repeati590 – 61122LRR 11
Add
BLAST
Repeati613 – 63422LRR 12
Add
BLAST
Repeati642 – 66524LRR 13
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi275 – 2773Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi177 – 27296Glu-rich
Add
BLAST
Compositional biasi252 – 27120Asp-rich
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ3MHH9.
KOiK08119.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MHH9-1 [UniParc]FASTAAdd to Basket

« Hide

MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR    50
QPGIQQMKTV TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG 100
HCLANGMIMY NKAVWSPEPC TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG 150
ECCPVCSNTE QREPTNLPHK QQSPPWEEMN RALRKEELQL EEDEEEVKQD 200
ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH QHRNPARENE 250
EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM 300
CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL 350
ERLDLSKNNI TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL 400
KINENKLQVI DEESLSDLNQ LVTLELEGNN LSETNVNSLA FKPLKSLSYL 450
RLGRNKFRII PQGLPASIEE LYLENNQIEE ITEISFNHTR KINVIGLRYN 500
KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV HLVLIGNQIE 550
RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE 600
LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN 650
NYIKTREIPS YAFSCIRSYS SIVLKPQNIK 680
Length:680
Mass (Da):78,062
Last modified:October 25, 2005 - v1
Checksum:i19D971D3301540EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105232 mRNA. Translation: AAI05233.1.
RefSeqiNP_001029769.1. NM_001034597.1.
UniGeneiBt.42321.

Genome annotation databases

GeneIDi533916.
KEGGibta:533916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105232 mRNA. Translation: AAI05233.1 .
RefSeqi NP_001029769.1. NM_001034597.1.
UniGenei Bt.42321.

3D structure databases

ProteinModelPortali Q3MHH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000015726.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 533916.
KEGGi bta:533916.

Organism-specific databases

CTDi 1842.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000112319.
HOVERGENi HBG031529.
InParanoidi Q3MHH9.
KOi K08119.

Miscellaneous databases

NextBioi 20876193.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00560. LRR_1. 2 hits.
PF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiECM2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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