Q3MHH9 (ECM2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Extracellular matrix protein 2

Gene names

Name:

ECM2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes matrix assembly and cell adhesiveness By similarity.
Subunit structure	Interacts with numerous extracellular matrix proteins By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Sequence similarities	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Contains 13 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Leucine-rich repeat Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 680	660	Extracellular matrix protein 2		PRO_0000287727
Regions
	Domain	100 – 157	58	VWFC
	Domain	288 – 325	38	LRRNT
	Repeat	349 – 369	21	LRR 1
	Repeat	375 – 396	22	LRR 2
	Repeat	397 – 417	21	LRR 3
	Repeat	420 – 440	21	LRR 4
	Repeat	446 – 466	21	LRR 5
	Repeat	467 – 488	22	LRR 6
	Repeat	491 – 511	21	LRR 7
	Repeat	517 – 538	22	LRR 8
	Repeat	539 – 559	21	LRR 9
	Repeat	563 – 583	21	LRR 10
	Repeat	590 – 611	22	LRR 11
	Repeat	613 – 634	22	LRR 12
	Repeat	642 – 665	24	LRR 13
	Motif	275 – 277	3	Cell attachment site Potential
	Compositional bias	177 – 272	96	Glu-rich
	Compositional bias	252 – 271	20	Asp-rich
Amino acid modifications
	Glycosylation	359	1	N-linked (GlcNAc...) Potential
	Glycosylation	430	1	N-linked (GlcNAc...) Potential
	Glycosylation	487	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3MHH9 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 19D971D3301540EF	FASTA	680	78,062
	10 20 30 40 50 60 MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR QPGIQQMKTV 70 80 90 100 110 120 TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG HCLANGMIMY NKAVWSPEPC 130 140 150 160 170 180 TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG ECCPVCSNTE QREPTNLPHK QQSPPWEEMN 190 200 210 220 230 240 RALRKEELQL EEDEEEVKQD ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH 250 260 270 280 290 300 QHRNPARENE EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM 310 320 330 340 350 360 CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL ERLDLSKNNI 370 380 390 400 410 420 TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL KINENKLQVI DEESLSDLNQ 430 440 450 460 470 480 LVTLELEGNN LSETNVNSLA FKPLKSLSYL RLGRNKFRII PQGLPASIEE LYLENNQIEE 490 500 510 520 530 540 ITEISFNHTR KINVIGLRYN KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV 550 560 570 580 590 600 HLVLIGNQIE RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE 610 620 630 640 650 660 LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN NYIKTREIPS 670 680 YAFSCIRSYS SIVLKPQNIK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105232 mRNA. Translation: AAI05233.1.
IPI	IPI00692442.
RefSeq	NP_001029769.1. NM_001034597.1.
UniGene	Bt.42321.
3D structure databases
ProteinModelPortal	Q3MHH9.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000015726.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	533916.
KEGG	bta:533916.
Organism-specific databases
CTD	1842.
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000112319.
HOVERGEN	HBG031529.
InParanoid	Q3MHH9.
KO	K08119.
OrthoDB	EOG4868CR.
Enzyme and pathway databases
BioCyc	CATTLE:533916-MONOMER.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00560. LRR_1. 2 hits. PF00093. VWC. 1 hit. [Graphical view]
SMART	SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 13 hits. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20876193.

Entry information

Entry name

ECM2_BOVIN

Accession

Primary (citable) accession number: Q3MHH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 25, 2005
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program