Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Gene namesi
Name:ECM2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 680660Extracellular matrix protein 2PRO_0000287727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 15758VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini288 – 32538LRRNTAdd
BLAST
Repeati349 – 36921LRR 1Add
BLAST
Repeati375 – 39622LRR 2Add
BLAST
Repeati397 – 41721LRR 3Add
BLAST
Repeati420 – 44021LRR 4Add
BLAST
Repeati446 – 46621LRR 5Add
BLAST
Repeati467 – 48822LRR 6Add
BLAST
Repeati491 – 51121LRR 7Add
BLAST
Repeati517 – 53822LRR 8Add
BLAST
Repeati539 – 55921LRR 9Add
BLAST
Repeati563 – 58321LRR 10Add
BLAST
Repeati590 – 61122LRR 11Add
BLAST
Repeati613 – 63422LRR 12Add
BLAST
Repeati642 – 66524LRR 13Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi275 – 2773Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi177 – 27296Glu-richAdd
BLAST
Compositional biasi252 – 27120Asp-richAdd
BLAST

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ3MHH9.
KOiK08119.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MHH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR
60 70 80 90 100
QPGIQQMKTV TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG
110 120 130 140 150
HCLANGMIMY NKAVWSPEPC TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG
160 170 180 190 200
ECCPVCSNTE QREPTNLPHK QQSPPWEEMN RALRKEELQL EEDEEEVKQD
210 220 230 240 250
ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH QHRNPARENE
260 270 280 290 300
EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM
310 320 330 340 350
CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL
360 370 380 390 400
ERLDLSKNNI TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL
410 420 430 440 450
KINENKLQVI DEESLSDLNQ LVTLELEGNN LSETNVNSLA FKPLKSLSYL
460 470 480 490 500
RLGRNKFRII PQGLPASIEE LYLENNQIEE ITEISFNHTR KINVIGLRYN
510 520 530 540 550
KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV HLVLIGNQIE
560 570 580 590 600
RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE
610 620 630 640 650
LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN
660 670 680
NYIKTREIPS YAFSCIRSYS SIVLKPQNIK
Length:680
Mass (Da):78,062
Last modified:October 25, 2005 - v1
Checksum:i19D971D3301540EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105232 mRNA. Translation: AAI05233.1.
RefSeqiNP_001029769.1. NM_001034597.1.
UniGeneiBt.42321.

Genome annotation databases

GeneIDi533916.
KEGGibta:533916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105232 mRNA. Translation: AAI05233.1.
RefSeqiNP_001029769.1. NM_001034597.1.
UniGeneiBt.42321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi533916.
KEGGibta:533916.

Organism-specific databases

CTDi1842.

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ3MHH9.
KOiK08119.

Miscellaneous databases

NextBioi20876193.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiECM2_BOVIN
AccessioniPrimary (citable) accession number: Q3MHH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 25, 2005
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.