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Q3MHH9 (ECM2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular matrix protein 2
Gene names
Name:ECM2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes matrix assembly and cell adhesiveness By similarity.

Subunit structure

Interacts with numerous extracellular matrix proteins By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 13 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainLeucine-rich repeat
Repeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 680660Extracellular matrix protein 2
PRO_0000287727

Regions

Domain100 – 15758VWFC
Domain288 – 32538LRRNT
Repeat349 – 36921LRR 1
Repeat375 – 39622LRR 2
Repeat397 – 41721LRR 3
Repeat420 – 44021LRR 4
Repeat446 – 46621LRR 5
Repeat467 – 48822LRR 6
Repeat491 – 51121LRR 7
Repeat517 – 53822LRR 8
Repeat539 – 55921LRR 9
Repeat563 – 58321LRR 10
Repeat590 – 61122LRR 11
Repeat613 – 63422LRR 12
Repeat642 – 66524LRR 13
Motif275 – 2773Cell attachment site Potential
Compositional bias177 – 27296Glu-rich
Compositional bias252 – 27120Asp-rich

Amino acid modifications

Glycosylation3591N-linked (GlcNAc...) Potential
Glycosylation4301N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3MHH9 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: 19D971D3301540EF

FASTA68078,062
        10         20         30         40         50         60 
MKFSSLYCFL LLLIFQTDFG QNEETSRRQR RKMYHRRLRK SSLSTHRSVR QPGIQQMKTV 

        70         80         90        100        110        120 
TPAAKLPIIN LDYSIEENFE SFLSVPGVES SYNVLPGKKG HCLANGMIMY NKAVWSPEPC 

       130        140        150        160        170        180 
TTCLCLNGKV LCDETKCHPQ MCPQTIIPEG ECCPVCSNTE QREPTNLPHK QQSPPWEEMN 

       190        200        210        220        230        240 
RALRKEELQL EEDEEEVKQD ENREQKKKTF RPGDWGRPIN EGQSREGKAQ RPEEEGRQAH 

       250        260        270        280        290        300 
QHRNPARENE EDDDEEEEDD DDEEEDDDDE DETIRGDTFR MPPRLPIPAT PRGIPSLPSM 

       310        320        330        340        350        360 
CSLSYKTISC ISADLTQIPP LTAPEITSLE LIDNSITSIP DEAFNGLPNL ERLDLSKNNI 

       370        380        390        400        410        420 
TSSGIGPKAF KFLKNLMRLN MDGNNLVTIP SELPSTLEEL KINENKLQVI DEESLSDLNQ 

       430        440        450        460        470        480 
LVTLELEGNN LSETNVNSLA FKPLKSLSYL RLGRNKFRII PQGLPASIEE LYLENNQIEE 

       490        500        510        520        530        540 
ITEISFNHTR KINVIGLRYN KIEENRIAPL AWINQENLES IDLSYNKLYH VPSYLPKSLV 

       550        560        570        580        590        600 
HLVLIGNQIE RIPGYVFGHM EPGLEYLYLS FNKLVDDGID RVSFYGAYHS LRELFLDHNE 

       610        620        630        640        650        660 
LKSIPPGVQE MKALHFLRLN NNKIRNILPE QICNAEEDDD SNLQHLHLEN NYIKTREIPS 

       670        680 
YAFSCIRSYS SIVLKPQNIK 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105232 mRNA. Translation: AAI05233.1.
RefSeqNP_001029769.1. NM_001034597.1.
UniGeneBt.42321.

3D structure databases

ProteinModelPortalQ3MHH9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015726.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID533916.
KEGGbta:533916.

Organism-specific databases

CTD1842.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000112319.
HOVERGENHBG031529.
InParanoidQ3MHH9.
KOK08119.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876193.

Entry information

Entry nameECM2_BOVIN
AccessionPrimary (citable) accession number: Q3MHH9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families