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Q3MHH4 (SYQ_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamine--tRNA ligase
EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
Name:QARS
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length775 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Subunit structure

Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutaminyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 775774Glutamine--tRNA ligase
PRO_0000245023

Regions

Motif270 – 28011"HIGH" region
Motif493 – 4975"KMSKS" region

Sites

Binding site4961ATP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue701Phosphoserine By similarity
Modified residue3091N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MHH4 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: C30C9EE302D532F0

FASTA77587,643
        10         20         30         40         50         60 
MAALDSLSLF TGLGLSEQKA RETLKNTVLS AQLREAATQA QQTLGSSIDK ATGTLLYGLA 

        70         80         90        100        110        120 
SRLRDPRRLS FLVSYITSRK IHTETQLSAA LEYVRSHPLD PINTEDFEQE CGVGVVVTPE 

       130        140        150        160        170        180 
QIEEAVEAAI NRHRAKLLVE RYHFSMGLLM GEARAALKWA DGKMIKHEVD MQVLHLLGPK 

       190        200        210        220        230        240 
TETDLEKKPK VAKARPEETD QRTAKDVVEN GEVVVQTLSL MEQLRGEALK FHKPGENYKT 

       250        260        270        280        290        300 
PGYVTTPHTM DLLKQHLDIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL 

       310        320        330        340        350        360 
RFDDTNPEKE EAKFFTAIYD MVAWLGYTPY KVTYASDYFD QLYAWAVELI RRDQAYVCHQ 

       370        380        390        400        410        420 
RGEELKGHNP LPSPWRDRPI EESLLLFEAM RKGKFAEGEA TLRMKLVMED GKMDPVAYRV 

       430        440        450        460        470        480 
KYTPHHRTGD TWCIYPTYDY THCLCDSIEH ITHSLCTKEF QARRSSYFWL CNALDVYCPV 

       490        500        510        520        530        540 
QWEYGRLNLH YAVVSKRKIL QLVAAGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG 

       550        560        570        580        590        600 
VTVAQTTMEP HLLEACVRDV LNDTAPRAMA VLEPLQVVIT NFPATKALDI QVPNFPADET 

       610        620        630        640        650        660 
KGFHQVPFGS TVFIERMDFK EEPEPGYKRL AWGQPVGLRH TGYVIELQHV VKGPSGCVES 

       670        680        690        700        710        720 
LKVTCRRADA GEKPKAFIHW VSQPLTCEIR LYERLFQHKN PEDPAEVPGG FLSDLNPASL 

       730        740        750        760        770 
QVVEAALVDC SVALAKPFDK FQFERLGYFS VDPDSNQGQL VFNRTVTLKE DPGKV

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT025487 mRNA. Translation: ABF57443.1.
BC105237 mRNA. Translation: AAI05238.1.
IPIIPI00708246.
RefSeqNP_001029640.1. NM_001034468.2.
UniGeneBt.7246.

3D structure databases

ProteinModelPortalQ3MHH4.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000025191.

Proteomic databases

PaxDbQ3MHH4.
PRIDEQ3MHH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID514586.
KEGGbta:514586.

Organism-specific databases

CTD5859.

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000259233.
HOVERGENHBG000889.
InParanoidQ3MHH4.
KOK01886.
OrthoDBEOG4ZKJKM.

Enzyme and pathway databases

BioCycCATTLE:514586-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth_Ib.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. Ribosomal_L25rel. 1 hit.
TIGRFAMsTIGR00440. glnS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ3MHH4.
NextBio20871410.

Entry information

Entry nameSYQ_BOVIN
AccessionPrimary (citable) accession number: Q3MHH4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 25, 2005
Last modified: May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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