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Q3MHH4

- SYQ_BOVIN

UniProt

Q3MHH4 - SYQ_BOVIN

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Protein

Glutamine--tRNA ligase

Gene

QARS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a critical role in brain development. Interacts with RARS.By similarity

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. brain development Source: UniProtKB
  2. glutaminyl-tRNA aminoacylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:QARS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 775774Glutamine--tRNA ligasePRO_0000245023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei309 – 3091N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3MHH4.
PRIDEiQ3MHH4.

Interactioni

Subunit structurei

Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.By similarity

Protein-protein interaction databases

IntActiQ3MHH4. 2 interactions.
STRINGi9913.ENSBTAP00000025191.

Structurei

3D structure databases

ProteinModelPortaliQ3MHH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi270 – 28011"HIGH" regionAdd
BLAST
Motifi493 – 4975"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000259233.
HOVERGENiHBG000889.
InParanoidiQ3MHH4.
KOiK01886.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3MHH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALDSLSLF TGLGLSEQKA RETLKNTVLS AQLREAATQA QQTLGSSIDK
60 70 80 90 100
ATGTLLYGLA SRLRDPRRLS FLVSYITSRK IHTETQLSAA LEYVRSHPLD
110 120 130 140 150
PINTEDFEQE CGVGVVVTPE QIEEAVEAAI NRHRAKLLVE RYHFSMGLLM
160 170 180 190 200
GEARAALKWA DGKMIKHEVD MQVLHLLGPK TETDLEKKPK VAKARPEETD
210 220 230 240 250
QRTAKDVVEN GEVVVQTLSL MEQLRGEALK FHKPGENYKT PGYVTTPHTM
260 270 280 290 300
DLLKQHLDIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL
310 320 330 340 350
RFDDTNPEKE EAKFFTAIYD MVAWLGYTPY KVTYASDYFD QLYAWAVELI
360 370 380 390 400
RRDQAYVCHQ RGEELKGHNP LPSPWRDRPI EESLLLFEAM RKGKFAEGEA
410 420 430 440 450
TLRMKLVMED GKMDPVAYRV KYTPHHRTGD TWCIYPTYDY THCLCDSIEH
460 470 480 490 500
ITHSLCTKEF QARRSSYFWL CNALDVYCPV QWEYGRLNLH YAVVSKRKIL
510 520 530 540 550
QLVAAGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG VTVAQTTMEP
560 570 580 590 600
HLLEACVRDV LNDTAPRAMA VLEPLQVVIT NFPATKALDI QVPNFPADET
610 620 630 640 650
KGFHQVPFGS TVFIERMDFK EEPEPGYKRL AWGQPVGLRH TGYVIELQHV
660 670 680 690 700
VKGPSGCVES LKVTCRRADA GEKPKAFIHW VSQPLTCEIR LYERLFQHKN
710 720 730 740 750
PEDPAEVPGG FLSDLNPASL QVVEAALVDC SVALAKPFDK FQFERLGYFS
760 770
VDPDSNQGQL VFNRTVTLKE DPGKV
Length:775
Mass (Da):87,643
Last modified:October 25, 2005 - v1
Checksum:iC30C9EE302D532F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025487 mRNA. Translation: ABF57443.1.
BC105237 mRNA. Translation: AAI05238.1.
RefSeqiNP_001029640.1. NM_001034468.2.
UniGeneiBt.7246.

Genome annotation databases

GeneIDi514586.
KEGGibta:514586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025487 mRNA. Translation: ABF57443.1 .
BC105237 mRNA. Translation: AAI05238.1 .
RefSeqi NP_001029640.1. NM_001034468.2.
UniGenei Bt.7246.

3D structure databases

ProteinModelPortali Q3MHH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3MHH4. 2 interactions.
STRINGi 9913.ENSBTAP00000025191.

Chemistry

BindingDBi Q3MHH4.

Proteomic databases

PaxDbi Q3MHH4.
PRIDEi Q3MHH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 514586.
KEGGi bta:514586.

Organism-specific databases

CTDi 5859.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000259233.
HOVERGENi HBG000889.
InParanoidi Q3MHH4.
KOi K01886.

Miscellaneous databases

NextBioi 20871410.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00440. glnS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiSYQ_BOVIN
AccessioniPrimary (citable) accession number: Q3MHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 25, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3