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Q3MHH4

- SYQ_BOVIN

UniProt

Q3MHH4 - SYQ_BOVIN

Protein

Glutamine--tRNA ligase

Gene

QARS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Plays a critical role in brain development. Interacts with RARS.By similarity

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei496 – 4961ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--tRNA ligase (EC:6.1.1.18)
    Alternative name(s):
    Glutaminyl-tRNA synthetase
    Short name:
    GlnRS
    Gene namesi
    Name:QARS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 775774Glutamine--tRNA ligasePRO_0000245023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei70 – 701PhosphoserineBy similarity
    Modified residuei309 – 3091N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ3MHH4.
    PRIDEiQ3MHH4.

    Interactioni

    Subunit structurei

    Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.By similarity

    Protein-protein interaction databases

    IntActiQ3MHH4. 2 interactions.
    STRINGi9913.ENSBTAP00000025191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MHH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi270 – 28011"HIGH" regionAdd
    BLAST
    Motifi493 – 4975"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000259233.
    HOVERGENiHBG000889.
    InParanoidiQ3MHH4.
    KOiK01886.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
    IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    PF04558. tRNA_synt_1c_R1. 1 hit.
    PF04557. tRNA_synt_1c_R2. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3MHH4-1 [UniParc]FASTAAdd to Basket

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    MAALDSLSLF TGLGLSEQKA RETLKNTVLS AQLREAATQA QQTLGSSIDK    50
    ATGTLLYGLA SRLRDPRRLS FLVSYITSRK IHTETQLSAA LEYVRSHPLD 100
    PINTEDFEQE CGVGVVVTPE QIEEAVEAAI NRHRAKLLVE RYHFSMGLLM 150
    GEARAALKWA DGKMIKHEVD MQVLHLLGPK TETDLEKKPK VAKARPEETD 200
    QRTAKDVVEN GEVVVQTLSL MEQLRGEALK FHKPGENYKT PGYVTTPHTM 250
    DLLKQHLDIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL 300
    RFDDTNPEKE EAKFFTAIYD MVAWLGYTPY KVTYASDYFD QLYAWAVELI 350
    RRDQAYVCHQ RGEELKGHNP LPSPWRDRPI EESLLLFEAM RKGKFAEGEA 400
    TLRMKLVMED GKMDPVAYRV KYTPHHRTGD TWCIYPTYDY THCLCDSIEH 450
    ITHSLCTKEF QARRSSYFWL CNALDVYCPV QWEYGRLNLH YAVVSKRKIL 500
    QLVAAGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG VTVAQTTMEP 550
    HLLEACVRDV LNDTAPRAMA VLEPLQVVIT NFPATKALDI QVPNFPADET 600
    KGFHQVPFGS TVFIERMDFK EEPEPGYKRL AWGQPVGLRH TGYVIELQHV 650
    VKGPSGCVES LKVTCRRADA GEKPKAFIHW VSQPLTCEIR LYERLFQHKN 700
    PEDPAEVPGG FLSDLNPASL QVVEAALVDC SVALAKPFDK FQFERLGYFS 750
    VDPDSNQGQL VFNRTVTLKE DPGKV 775
    Length:775
    Mass (Da):87,643
    Last modified:October 25, 2005 - v1
    Checksum:iC30C9EE302D532F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025487 mRNA. Translation: ABF57443.1.
    BC105237 mRNA. Translation: AAI05238.1.
    RefSeqiNP_001029640.1. NM_001034468.2.
    UniGeneiBt.7246.

    Genome annotation databases

    GeneIDi514586.
    KEGGibta:514586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT025487 mRNA. Translation: ABF57443.1 .
    BC105237 mRNA. Translation: AAI05238.1 .
    RefSeqi NP_001029640.1. NM_001034468.2.
    UniGenei Bt.7246.

    3D structure databases

    ProteinModelPortali Q3MHH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3MHH4. 2 interactions.
    STRINGi 9913.ENSBTAP00000025191.

    Chemistry

    BindingDBi Q3MHH4.

    Proteomic databases

    PaxDbi Q3MHH4.
    PRIDEi Q3MHH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 514586.
    KEGGi bta:514586.

    Organism-specific databases

    CTDi 5859.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000259233.
    HOVERGENi HBG000889.
    InParanoidi Q3MHH4.
    KOi K01886.

    Miscellaneous databases

    NextBioi 20871410.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
    IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    PF04558. tRNA_synt_1c_R1. 1 hit.
    PF04557. tRNA_synt_1c_R2. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiSYQ_BOVIN
    AccessioniPrimary (citable) accession number: Q3MHH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3