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Q3MHG7 (URIC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uricase
EC=1.7.3.3
Alternative name(s):
Urate oxidase
Gene names
Name:UOX
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity.

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathway

Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the uricase family.

Ontologies

Keywords
   Biological processPurine metabolism
   Cellular componentPeroxisome
   Molecular functionOxidoreductase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpurine base metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionurate oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 304303Uricase
PRO_0000165982

Regions

Region68 – 692Substrate binding By similarity
Region235 – 2362Substrate binding By similarity
Motif302 – 3043Microbody targeting signal Potential

Sites

Active site1871Charge relay system By similarity
Active site2361Charge relay system By similarity
Binding site1871Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue361N6-acetyllysine By similarity
Modified residue391Phosphoserine By similarity
Modified residue1181N6-acetyllysine By similarity
Modified residue1221N6-acetyllysine By similarity
Modified residue1641N6-acetyllysine By similarity
Modified residue1851N6-acetyllysine By similarity
Modified residue2211N6-acetyllysine By similarity
Modified residue2281N6-acetyllysine By similarity
Modified residue2321Phosphoserine By similarity
Modified residue2781N6-acetyllysine By similarity
Modified residue3021Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3MHG7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D6D4DBE3892D1ED3

FASTA30435,124
        10         20         30         40         50         60 
MAHYHNDYQK NDEVEFVRTG YGKDMVKVLH IQRDGKYHSI KEVATSVQLT LNSRREYLHG 

        70         80         90        100        110        120 
DNSDIIPTDT IKNTVQVLAK FKGIKSIETF AMNICEHFLS SFNHVIRVQV YVEEVPWKRF 

       130        140        150        160        170        180 
EKNGVKHVHA FIHTPTGTHF CEVEQLRSGP PVIHSGIKDL KVLKTTQSGF EGFLKDQFTT 

       190        200        210        220        230        240 
LPEVKDRCFA TQVYCKWRYH QGRDVDFEAT WEAVRGIVLK KFAGPYDKGE YSPSVQKTLY 

       250        260        270        280        290        300 
DIQVLSLSQL PEIEDMEISL PNIHYFNIDM SKMGLINKEE VLLPLDNPYG RITGTVKRKL 


TSRL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Rumen reticulum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC105244 mRNA. Translation: AAI05245.1.
IPIIPI00685987.
RefSeqNP_001069116.1. NM_001075648.1.
UniGeneBt.25743.

3D structure databases

ProteinModelPortalQ3MHG7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3MHG7.

Proteomic databases

PRIDEQ3MHG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000033492; ENSBTAP00000033405; ENSBTAG00000024255.
GeneID514113.
KEGGbta:514113.

Organism-specific databases

CTD391051.

Phylogenomic databases

eggNOGmaNOG11619.
GeneTreeENSGT00390000010863.
HOVERGENHBG018060.
InParanoidQ3MHG7.
OMANSDIVAT.
OrthoDBEOG4DNF4Z.

Family and domain databases

InterProIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
Gene3DG3DSA:3.10.270.10. Uricase. 1 hit.
KOK00365.
PANTHERPTHR10395:SF1. Uricase. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFPIRSF000241. Urate_oxidase. 1 hit.
PRINTSPR00093. URICASE.
TIGRFAMsTIGR03383. Urate_oxi. 1 hit.
PROSITEPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameURIC_BOVIN
AccessionPrimary (citable) accession number: Q3MHG7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 50 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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