Uricase - Bos taurus (Bovine)

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Reviewed, UniProtKB/Swiss-Prot Q3MHG7 (URIC_BOVIN)

Last modified June 16, 2009. Version 31. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Uricase
    EC=1.7.3.3
Alternative name(s):
    Urate oxidase

Gene names

Name:

UOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which spontaneously decomposes to form allantoin By similarity.
Catalytic activity	Urate + O₂ + H₂O = 5-hydroxyisourate + H₂O₂.
Pathway	Purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 1/3.
Subunit structure	Homotetramer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the uricase family.

Ontologies

Keywords
Biological process	Purine metabolism
Cellular component	Peroxisome
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	urate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

303

Uricase

PRO_0000165982

Regions

Region

2

Substrate binding By similarity

Motif

3

Microbody targeting signal Potential

Sites

Active site

1

Charge relay system By similarity

Active site

1

Charge relay system By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Amino acid modifications

Modified residue

1

N-acetylalanine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

Phosphoserine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

Phosphoserine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q3MHG7-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D6D4DBE3892D1ED3
Show »

304

35,124

        10         20         30         40         50         60 
MAHYHNDYQK NDEVEFVRTG YGKDMVKVLH IQRDGKYHSI KEVATSVQLT LNSRREYLHG 

        70         80         90        100        110        120 
DNSDIIPTDT IKNTVQVLAK FKGIKSIETF AMNICEHFLS SFNHVIRVQV YVEEVPWKRF 

       130        140        150        160        170        180 
EKNGVKHVHA FIHTPTGTHF CEVEQLRSGP PVIHSGIKDL KVLKTTQSGF EGFLKDQFTT 

       190        200        210        220        230        240 
LPEVKDRCFA TQVYCKWRYH QGRDVDFEAT WEAVRGIVLK KFAGPYDKGE YSPSVQKTLY 

       250        260        270        280        290        300 
DIQVLSLSQL PEIEDMEISL PNIHYFNIDM SKMGLINKEE VLLPLDNPYG RITGTVKRKL 


TSRL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Rumen reticulum.

Cross-references

Sequence databases
	BC105244 mRNA. Translation: AAI05245.1.
IPI	IPI00685987.
RefSeq	NP_001069116.1.
UniGene	Bt.25743
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000024255. Bos taurus. [Contig view]
GeneID	514113.
KEGG	bta:514113.
Phylogenomic databases
HOVERGEN	Q3MHG7.
OMA	Q3MHG7. KTTQSGF.
Enzyme and pathway databases
BRENDA	1.7.3.3. 251.
Family and domain databases
InterPro	IPR002042. Uricase. IPR019842. Uricase_CS. [Graphical view]
Gene3D	G3DSA:3.10.270.10. Uricase. 1 hit.
PANTHER	PTHR10395:SF1. Uricase. 1 hit.
Pfam	PF01014. Uricase. 2 hits. [Graphical view]
PRINTS	PR00093. URICASE.
ProDom	PD003367. Uricase. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03383. urate_oxi. 1 hit.
PROSITE	PS00366. URICASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URIC_BOVIN

Accession

Primary (citable) accession number: Q3MHG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents