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Protein

Signal recognition particle receptor subunit alpha

Gene

SRPRA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi426 – 4338GTPBy similarity
Nucleotide bindingi521 – 5255GTPBy similarity
Nucleotide bindingi589 – 5924GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SRPRABy similarity
Synonyms:SRPR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Signal recognition particle receptor subunit alphaPRO_0000282927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphoserineBy similarity
Modified residuei285 – 2851PhosphothreonineBy similarity
Modified residuei297 – 2971PhosphoserineBy similarity
Modified residuei298 – 2981PhosphoserineBy similarity
Modified residuei299 – 2991PhosphoserineBy similarity
Modified residuei474 – 4741PhosphoserineBy similarity
Modified residuei579 – 5791PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MHE8.
PRIDEiQ3MHE8.

Interactioni

Subunit structurei

Heterodimer with SRPRB.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018762.

Structurei

3D structure databases

ProteinModelPortaliQ3MHE8.
SMRiQ3MHE8. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiQ3MHE8.
KOiK13431.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKP KEKAKNNKKN KGAKKEGSDG PLATSKAAPA EKSGLPVGPE
210 220 230 240 250
NGEELSKEEQ IRRKREEFIQ KHGRGMEKSS KSSKSDAPKE KGKKAPRVWA
260 270 280 290 300
LGGSANKEVL DYSTPTTNGA PEAAPPEDIN LIRGTGPGRQ LQDLDCSSSD
310 320 330 340 350
DEGAAQNSTK PSATKGTLGG MFGMLKGLVG SKSLTREDME SVLDKMRDHL
360 370 380 390 400
IAKNVAADIA VQLCESVANK LEGKVMGTFS TVTSTVKQAL QESLVQILQP
410 420 430 440 450
QRRVDMLRDI MDAQRHQRPY VVTFCGVNGV GKSTNLAKIS FWLLENGFSV
460 470 480 490 500
LIAACDTFRA GAVEQLRTHT RRLSALHPPE KHGGRTMVQL FEKGYGKDAA
510 520 530 540 550
GIAMEAIAFA RNQGFDVVLV DTAGRMQDNA PLMTALAKLI TVNTPDLVLF
560 570 580 590 600
VGEALVGNEA VDQLVKFNRA LADHSMAQTP RLIDGIVLTK FDTIDDKVGA
610 620 630
AISMTYITSK PIVFVGTGQT YCDLRSLNAK AVVAALMKA
Length:639
Mass (Da):69,896
Last modified:October 25, 2005 - v1
Checksum:i29052DEA87E08845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105264 mRNA. Translation: AAI05265.1.
RefSeqiNP_001068590.1. NM_001075122.1.
UniGeneiBt.5518.

Genome annotation databases

GeneIDi281504.
KEGGibta:281504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105264 mRNA. Translation: AAI05265.1.
RefSeqiNP_001068590.1. NM_001075122.1.
UniGeneiBt.5518.

3D structure databases

ProteinModelPortaliQ3MHE8.
SMRiQ3MHE8. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018762.

Proteomic databases

PaxDbiQ3MHE8.
PRIDEiQ3MHE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281504.
KEGGibta:281504.

Organism-specific databases

CTDi6734.

Phylogenomic databases

eggNOGiKOG0781. Eukaryota.
COG0552. LUCA.
HOGENOMiHOG000201671.
HOVERGENiHBG047566.
InParanoidiQ3MHE8.
KOiK13431.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011012. Longin-like_dom.
IPR027417. P-loop_NTPase.
IPR007222. Sig_recog_particle_rcpt_asu_N.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF04086. SRP-alpha_N. 1 hit.
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00300. SRP54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiSRPRA_BOVIN
AccessioniPrimary (citable) accession number: Q3MHE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 25, 2005
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.