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Protein

Signal recognition particle receptor subunit alpha

Gene

SRPRA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi426 – 433GTPBy similarity8
Nucleotide bindingi521 – 525GTPBy similarity5
Nucleotide bindingi589 – 592GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SRPRABy similarity
Synonyms:SRPR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829271 – 639Signal recognition particle receptor subunit alphaAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineBy similarity1
Modified residuei285PhosphothreonineBy similarity1
Modified residuei297PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei474PhosphoserineBy similarity1
Modified residuei579PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3MHE8
PRIDEiQ3MHE8

Interactioni

Subunit structurei

Heterodimer with SRPRB.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018762

Structurei

3D structure databases

ProteinModelPortaliQ3MHE8
SMRiQ3MHE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781 Eukaryota
COG0552 LUCA
HOGENOMiHOG000201671
HOVERGENiHBG047566
InParanoidiQ3MHE8
KOiK13431

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011012 Longin-like_dom_sf
IPR027417 P-loop_NTPase
IPR007222 Sig_recog_particle_rcpt_asu_N
IPR013822 Signal_recog_particl_SRP54_hlx
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PfamiView protein in Pfam
PF04086 SRP-alpha_N, 1 hit
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

Q3MHE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKP KEKAKNNKKN KGAKKEGSDG PLATSKAAPA EKSGLPVGPE
210 220 230 240 250
NGEELSKEEQ IRRKREEFIQ KHGRGMEKSS KSSKSDAPKE KGKKAPRVWA
260 270 280 290 300
LGGSANKEVL DYSTPTTNGA PEAAPPEDIN LIRGTGPGRQ LQDLDCSSSD
310 320 330 340 350
DEGAAQNSTK PSATKGTLGG MFGMLKGLVG SKSLTREDME SVLDKMRDHL
360 370 380 390 400
IAKNVAADIA VQLCESVANK LEGKVMGTFS TVTSTVKQAL QESLVQILQP
410 420 430 440 450
QRRVDMLRDI MDAQRHQRPY VVTFCGVNGV GKSTNLAKIS FWLLENGFSV
460 470 480 490 500
LIAACDTFRA GAVEQLRTHT RRLSALHPPE KHGGRTMVQL FEKGYGKDAA
510 520 530 540 550
GIAMEAIAFA RNQGFDVVLV DTAGRMQDNA PLMTALAKLI TVNTPDLVLF
560 570 580 590 600
VGEALVGNEA VDQLVKFNRA LADHSMAQTP RLIDGIVLTK FDTIDDKVGA
610 620 630
AISMTYITSK PIVFVGTGQT YCDLRSLNAK AVVAALMKA
Length:639
Mass (Da):69,896
Last modified:October 25, 2005 - v1
Checksum:i29052DEA87E08845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105264 mRNA Translation: AAI05265.1
RefSeqiNP_001068590.1, NM_001075122.1
UniGeneiBt.5518

Genome annotation databases

GeneIDi281504
KEGGibta:281504

Similar proteinsi

Entry informationi

Entry nameiSRPRA_BOVIN
AccessioniPrimary (citable) accession number: Q3MHE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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