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Protein

Protein LSM12 homolog

Gene

LSM12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM12 homolog
Gene namesi
Name:LSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26407. LSM12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 195194Protein LSM12 homologPRO_0000305126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei75 – 751Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3MHD2.
PaxDbiQ3MHD2.
PeptideAtlasiQ3MHD2.
PRIDEiQ3MHD2.

Expressioni

Gene expression databases

BgeeiQ3MHD2.
CleanExiHS_LSM12.
ExpressionAtlasiQ3MHD2. baseline and differential.
GenevestigatoriQ3MHD2.

Organism-specific databases

HPAiHPA051934.

Interactioni

Protein-protein interaction databases

BioGridi125889. 15 interactions.
IntActiQ3MHD2. 4 interactions.
STRINGi9606.ENSP00000293406.

Structurei

3D structure databases

ProteinModelPortaliQ3MHD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LSM12 family.Curated

Phylogenomic databases

eggNOGiNOG324640.
GeneTreeiENSGT00390000006956.
HOGENOMiHOG000006611.
HOVERGENiHBG057351.
InParanoidiQ3MHD2.
OMAiLILKCPS.
OrthoDBiEOG7XPZ6S.
PhylomeDBiQ3MHD2.

Family and domain databases

InterProiIPR019181. Anticodon-binding_dom.
[Graphical view]
PfamiPF09793. AD. 1 hit.
[Graphical view]
SMARTiSM00995. AD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3MHD2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP
60 70 80 90 100
NHADILLINL QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS
110 120 130 140 150
QAYAISAGVS LEGQQLFQTI HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN
160 170 180 190
CKGKEGSALS HVRKIVEKHF RDVESQKILQ RSQAQQPQKE AALSS
Length:195
Mass (Da):21,701
Last modified:October 2, 2007 - v2
Checksum:iBCEDE62DA43D86C7
GO
Isoform 2 (identifier: Q3MHD2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: K → ISPE

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):21,999
Checksum:iB955DE52C1730E8E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771P → R.1 Publication
Corresponds to variant rs17854322 [ dbSNP | Ensembl ].
VAR_035166
Natural varianti173 – 1731V → L.
Corresponds to variant rs59168537 [ dbSNP | Ensembl ].
VAR_062209

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 421K → ISPE in isoform 2. 1 PublicationVSP_028241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055218 mRNA. Translation: BAB70877.1.
BC044587 mRNA. Translation: AAH44587.1.
BC105288 mRNA. Translation: AAI05289.1.
CCDSiCCDS11475.1. [Q3MHD2-1]
RefSeqiNP_689557.1. NM_152344.3. [Q3MHD2-1]
UniGeneiHs.355570.

Genome annotation databases

EnsembliENST00000293406; ENSP00000293406; ENSG00000161654. [Q3MHD2-1]
ENST00000591247; ENSP00000466718; ENSG00000161654. [Q3MHD2-1]
GeneIDi124801.
KEGGihsa:124801.
UCSCiuc002iev.3. human. [Q3MHD2-1]

Polymorphism databases

DMDMi158705881.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055218 mRNA. Translation: BAB70877.1.
BC044587 mRNA. Translation: AAH44587.1.
BC105288 mRNA. Translation: AAI05289.1.
CCDSiCCDS11475.1. [Q3MHD2-1]
RefSeqiNP_689557.1. NM_152344.3. [Q3MHD2-1]
UniGeneiHs.355570.

3D structure databases

ProteinModelPortaliQ3MHD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125889. 15 interactions.
IntActiQ3MHD2. 4 interactions.
STRINGi9606.ENSP00000293406.

Polymorphism databases

DMDMi158705881.

Proteomic databases

MaxQBiQ3MHD2.
PaxDbiQ3MHD2.
PeptideAtlasiQ3MHD2.
PRIDEiQ3MHD2.

Protocols and materials databases

DNASUi124801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293406; ENSP00000293406; ENSG00000161654. [Q3MHD2-1]
ENST00000591247; ENSP00000466718; ENSG00000161654. [Q3MHD2-1]
GeneIDi124801.
KEGGihsa:124801.
UCSCiuc002iev.3. human. [Q3MHD2-1]

Organism-specific databases

CTDi124801.
GeneCardsiGC17M042112.
H-InvDBHIX0034611.
HGNCiHGNC:26407. LSM12.
HPAiHPA051934.
MIMi611793. gene.
neXtProtiNX_Q3MHD2.
PharmGKBiPA142671502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG324640.
GeneTreeiENSGT00390000006956.
HOGENOMiHOG000006611.
HOVERGENiHBG057351.
InParanoidiQ3MHD2.
OMAiLILKCPS.
OrthoDBiEOG7XPZ6S.
PhylomeDBiQ3MHD2.

Miscellaneous databases

ChiTaRSiLSM12. human.
GenomeRNAii124801.
NextBioi81384.
PROiQ3MHD2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3MHD2.
CleanExiHS_LSM12.
ExpressionAtlasiQ3MHD2. baseline and differential.
GenevestigatoriQ3MHD2.

Family and domain databases

InterProiIPR019181. Anticodon-binding_dom.
[Graphical view]
PfamiPF09793. AD. 1 hit.
[Graphical view]
SMARTiSM00995. AD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128 (ISOFORM 2), VARIANT ARG-77.
    Tissue: Brain.
  3. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-18; 25-37 AND 73-86, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSM12_HUMAN
AccessioniPrimary (citable) accession number: Q3MHD2
Secondary accession number(s): Q86YB1, Q96NL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.