Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3MHD2

- LSM12_HUMAN

UniProt

Q3MHD2 - LSM12_HUMAN

Protein

Protein LSM12 homolog

Gene

LSM12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LSM12 homolog
    Gene namesi
    Name:LSM12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26407. LSM12.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 195194Protein LSM12 homologPRO_0000305126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei75 – 751Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3MHD2.
    PaxDbiQ3MHD2.
    PeptideAtlasiQ3MHD2.
    PRIDEiQ3MHD2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3MHD2.
    BgeeiQ3MHD2.
    CleanExiHS_LSM12.
    GenevestigatoriQ3MHD2.

    Organism-specific databases

    HPAiHPA051934.

    Interactioni

    Protein-protein interaction databases

    BioGridi125889. 14 interactions.
    IntActiQ3MHD2. 4 interactions.
    STRINGi9606.ENSP00000293406.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MHD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LSM12 family.Curated

    Phylogenomic databases

    eggNOGiNOG324640.
    HOGENOMiHOG000006611.
    HOVERGENiHBG057351.
    InParanoidiQ3MHD2.
    OMAiNDVILIN.
    OrthoDBiEOG7XPZ6S.
    PhylomeDBiQ3MHD2.

    Family and domain databases

    InterProiIPR019181. Anticodon-binding_dom.
    [Graphical view]
    PfamiPF09793. AD. 1 hit.
    [Graphical view]
    SMARTiSM00995. AD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3MHD2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP    50
    NHADILLINL QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS 100
    QAYAISAGVS LEGQQLFQTI HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN 150
    CKGKEGSALS HVRKIVEKHF RDVESQKILQ RSQAQQPQKE AALSS 195
    Length:195
    Mass (Da):21,701
    Last modified:October 2, 2007 - v2
    Checksum:iBCEDE62DA43D86C7
    GO
    Isoform 2 (identifier: Q3MHD2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-42: K → ISPE

    Note: No experimental confirmation available.

    Show »
    Length:198
    Mass (Da):21,999
    Checksum:iB955DE52C1730E8E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771P → R.1 Publication
    Corresponds to variant rs17854322 [ dbSNP | Ensembl ].
    VAR_035166
    Natural varianti173 – 1731V → L.
    Corresponds to variant rs59168537 [ dbSNP | Ensembl ].
    VAR_062209

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 421K → ISPE in isoform 2. 1 PublicationVSP_028241

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055218 mRNA. Translation: BAB70877.1.
    BC044587 mRNA. Translation: AAH44587.1.
    BC105288 mRNA. Translation: AAI05289.1.
    CCDSiCCDS11475.1. [Q3MHD2-1]
    RefSeqiNP_689557.1. NM_152344.3. [Q3MHD2-1]
    UniGeneiHs.355570.

    Genome annotation databases

    EnsembliENST00000293406; ENSP00000293406; ENSG00000161654. [Q3MHD2-1]
    ENST00000591247; ENSP00000466718; ENSG00000161654. [Q3MHD2-1]
    GeneIDi124801.
    KEGGihsa:124801.
    UCSCiuc002iev.3. human. [Q3MHD2-1]

    Polymorphism databases

    DMDMi158705881.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055218 mRNA. Translation: BAB70877.1 .
    BC044587 mRNA. Translation: AAH44587.1 .
    BC105288 mRNA. Translation: AAI05289.1 .
    CCDSi CCDS11475.1. [Q3MHD2-1 ]
    RefSeqi NP_689557.1. NM_152344.3. [Q3MHD2-1 ]
    UniGenei Hs.355570.

    3D structure databases

    ProteinModelPortali Q3MHD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125889. 14 interactions.
    IntActi Q3MHD2. 4 interactions.
    STRINGi 9606.ENSP00000293406.

    Polymorphism databases

    DMDMi 158705881.

    Proteomic databases

    MaxQBi Q3MHD2.
    PaxDbi Q3MHD2.
    PeptideAtlasi Q3MHD2.
    PRIDEi Q3MHD2.

    Protocols and materials databases

    DNASUi 124801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293406 ; ENSP00000293406 ; ENSG00000161654 . [Q3MHD2-1 ]
    ENST00000591247 ; ENSP00000466718 ; ENSG00000161654 . [Q3MHD2-1 ]
    GeneIDi 124801.
    KEGGi hsa:124801.
    UCSCi uc002iev.3. human. [Q3MHD2-1 ]

    Organism-specific databases

    CTDi 124801.
    GeneCardsi GC17M042112.
    H-InvDB HIX0034611.
    HGNCi HGNC:26407. LSM12.
    HPAi HPA051934.
    MIMi 611793. gene.
    neXtProti NX_Q3MHD2.
    PharmGKBi PA142671502.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324640.
    HOGENOMi HOG000006611.
    HOVERGENi HBG057351.
    InParanoidi Q3MHD2.
    OMAi NDVILIN.
    OrthoDBi EOG7XPZ6S.
    PhylomeDBi Q3MHD2.

    Miscellaneous databases

    ChiTaRSi LSM12. human.
    GenomeRNAii 124801.
    NextBioi 81384.
    PROi Q3MHD2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3MHD2.
    Bgeei Q3MHD2.
    CleanExi HS_LSM12.
    Genevestigatori Q3MHD2.

    Family and domain databases

    InterProi IPR019181. Anticodon-binding_dom.
    [Graphical view ]
    Pfami PF09793. AD. 1 hit.
    [Graphical view ]
    SMARTi SM00995. AD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128 (ISOFORM 2), VARIANT ARG-77.
      Tissue: Brain.
    3. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-18; 25-37 AND 73-86, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLSM12_HUMAN
    AccessioniPrimary (citable) accession number: Q3MHD2
    Secondary accession number(s): Q86YB1, Q96NL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3