Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3MHD2

- LSM12_HUMAN

UniProt

Q3MHD2 - LSM12_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein LSM12 homolog

Gene

LSM12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM12 homolog
Gene namesi
Name:LSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26407. LSM12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 195194Protein LSM12 homologPRO_0000305126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei75 – 751Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3MHD2.
PaxDbiQ3MHD2.
PeptideAtlasiQ3MHD2.
PRIDEiQ3MHD2.

Expressioni

Gene expression databases

BgeeiQ3MHD2.
CleanExiHS_LSM12.
ExpressionAtlasiQ3MHD2. baseline and differential.
GenevestigatoriQ3MHD2.

Organism-specific databases

HPAiHPA051934.

Interactioni

Protein-protein interaction databases

BioGridi125889. 14 interactions.
IntActiQ3MHD2. 4 interactions.
STRINGi9606.ENSP00000293406.

Structurei

3D structure databases

ProteinModelPortaliQ3MHD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LSM12 family.Curated

Phylogenomic databases

eggNOGiNOG324640.
GeneTreeiENSGT00390000006956.
HOGENOMiHOG000006611.
HOVERGENiHBG057351.
InParanoidiQ3MHD2.
OMAiNDVILIN.
OrthoDBiEOG7XPZ6S.
PhylomeDBiQ3MHD2.

Family and domain databases

InterProiIPR019181. Anticodon-binding_dom.
[Graphical view]
PfamiPF09793. AD. 1 hit.
[Graphical view]
SMARTiSM00995. AD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3MHD2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP
60 70 80 90 100
NHADILLINL QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS
110 120 130 140 150
QAYAISAGVS LEGQQLFQTI HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN
160 170 180 190
CKGKEGSALS HVRKIVEKHF RDVESQKILQ RSQAQQPQKE AALSS
Length:195
Mass (Da):21,701
Last modified:October 2, 2007 - v2
Checksum:iBCEDE62DA43D86C7
GO
Isoform 2 (identifier: Q3MHD2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: K → ISPE

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):21,999
Checksum:iB955DE52C1730E8E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771P → R.1 Publication
Corresponds to variant rs17854322 [ dbSNP | Ensembl ].
VAR_035166
Natural varianti173 – 1731V → L.
Corresponds to variant rs59168537 [ dbSNP | Ensembl ].
VAR_062209

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 421K → ISPE in isoform 2. 1 PublicationVSP_028241

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055218 mRNA. Translation: BAB70877.1.
BC044587 mRNA. Translation: AAH44587.1.
BC105288 mRNA. Translation: AAI05289.1.
CCDSiCCDS11475.1. [Q3MHD2-1]
RefSeqiNP_689557.1. NM_152344.3. [Q3MHD2-1]
UniGeneiHs.355570.

Genome annotation databases

EnsembliENST00000293406; ENSP00000293406; ENSG00000161654. [Q3MHD2-1]
ENST00000591247; ENSP00000466718; ENSG00000161654. [Q3MHD2-1]
GeneIDi124801.
KEGGihsa:124801.
UCSCiuc002iev.3. human. [Q3MHD2-1]

Polymorphism databases

DMDMi158705881.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK055218 mRNA. Translation: BAB70877.1 .
BC044587 mRNA. Translation: AAH44587.1 .
BC105288 mRNA. Translation: AAI05289.1 .
CCDSi CCDS11475.1. [Q3MHD2-1 ]
RefSeqi NP_689557.1. NM_152344.3. [Q3MHD2-1 ]
UniGenei Hs.355570.

3D structure databases

ProteinModelPortali Q3MHD2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125889. 14 interactions.
IntActi Q3MHD2. 4 interactions.
STRINGi 9606.ENSP00000293406.

Polymorphism databases

DMDMi 158705881.

Proteomic databases

MaxQBi Q3MHD2.
PaxDbi Q3MHD2.
PeptideAtlasi Q3MHD2.
PRIDEi Q3MHD2.

Protocols and materials databases

DNASUi 124801.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293406 ; ENSP00000293406 ; ENSG00000161654 . [Q3MHD2-1 ]
ENST00000591247 ; ENSP00000466718 ; ENSG00000161654 . [Q3MHD2-1 ]
GeneIDi 124801.
KEGGi hsa:124801.
UCSCi uc002iev.3. human. [Q3MHD2-1 ]

Organism-specific databases

CTDi 124801.
GeneCardsi GC17M042112.
H-InvDB HIX0034611.
HGNCi HGNC:26407. LSM12.
HPAi HPA051934.
MIMi 611793. gene.
neXtProti NX_Q3MHD2.
PharmGKBi PA142671502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324640.
GeneTreei ENSGT00390000006956.
HOGENOMi HOG000006611.
HOVERGENi HBG057351.
InParanoidi Q3MHD2.
OMAi NDVILIN.
OrthoDBi EOG7XPZ6S.
PhylomeDBi Q3MHD2.

Miscellaneous databases

ChiTaRSi LSM12. human.
GenomeRNAii 124801.
NextBioi 81384.
PROi Q3MHD2.
SOURCEi Search...

Gene expression databases

Bgeei Q3MHD2.
CleanExi HS_LSM12.
ExpressionAtlasi Q3MHD2. baseline and differential.
Genevestigatori Q3MHD2.

Family and domain databases

InterProi IPR019181. Anticodon-binding_dom.
[Graphical view ]
Pfami PF09793. AD. 1 hit.
[Graphical view ]
SMARTi SM00995. AD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-128 (ISOFORM 2), VARIANT ARG-77.
    Tissue: Brain.
  3. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-18; 25-37 AND 73-86, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSM12_HUMAN
AccessioniPrimary (citable) accession number: Q3MHD2
Secondary accession number(s): Q86YB1, Q96NL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3