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Protein

Integrator complex subunit 11

Gene

Ints11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-RNO-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Gene namesi
Name:Ints11
Synonyms:Cpsf3l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306841. Cpsf3l.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595661 – 600Integrator complex subunit 11Add BLAST600

Proteomic databases

PaxDbiQ3MHC2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019712.
GenevisibleiQ3MHC2. RN.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026725.

Structurei

3D structure databases

ProteinModelPortaliQ3MHC2.
SMRiQ3MHC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 73HXHXDH motif6

Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1137. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00890000139395.
HOGENOMiHOG000231294.
HOVERGENiHBG080215.
InParanoidiQ3MHC2.
KOiK13148.
OMAiYLDGMIW.
OrthoDBiEOG091G03RH.
PhylomeDBiQ3MHC2.
TreeFamiTF105878.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
InterProiView protein in InterPro
IPR022712. Beta_Casp.
IPR001279. Metallo-B-lactamas.
IPR011108. RMMBL.
PfamiView protein in Pfam
PF10996. Beta-Casp. 1 hit.
PF16661. Lactamase_B_6. 1 hit.
PF07521. RMMBL. 1 hit.
SMARTiView protein in SMART
SM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3MHC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY
60 70 80 90 100
ITQSGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC
110 120 130 140 150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI
160 170 180 190 200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL
210 220 230 240 250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI
260 270 280 290 300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
310 320 330 340 350
EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM
360 370 380 390 400
PGYCVQGTVG HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ
410 420 430 440 450
LVGQAEPESV LLVHGEAKKM EFLRQKIEQE FRVSCYMPAN GETVTLPTSP
460 470 480 490 500
SIPVGISLGL LKREMVQGLL PEAKKPRLLH GTLIMKDNNF RLVSSEQALK
510 520 530 540 550
ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD HCVQHLPDGS
560 570 580 590 600
VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTAL LKNGLPQAPS
Length:600
Mass (Da):67,841
Last modified:October 25, 2005 - v1
Checksum:i20E48D38DC3640B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105303 mRNA. Translation: AAI05304.1.
RefSeqiNP_001029064.2. NM_001033892.2.
UniGeneiRn.98615.

Genome annotation databases

EnsembliENSRNOT00000026725; ENSRNOP00000026725; ENSRNOG00000019712.
GeneIDi298688.
KEGGirno:298688.

Similar proteinsi

Entry informationi

Entry nameiINT11_RAT
AccessioniPrimary (citable) accession number: Q3MHC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2005
Last modified: August 30, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families