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Q3MHC1

- NAA60_RAT

UniProt

Q3MHC1 - NAA60_RAT

Protein

N-alpha-acetyltransferase 60

Gene

Naa60

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: UniProtKB
    2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. chromosome segregation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
    5. nucleosome assembly Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
    Alternative name(s):
    GNAT acetyltransferase
    N-acetyltransferase 15
    NatF catalytic subunit
    Gene namesi
    Name:Naa60
    Synonyms:Nat15
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1308915. Naa60.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321568Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei105 – 1051N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei109 – 1091N6-acetyllysine; by autocatalysisBy similarity
    Modified residuei121 – 1211N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Acetylated: autoacetylation is required for optimal acetyltransferase activity.By similarity

    Keywords - PTMi

    Acetylation

    Expressioni

    Gene expression databases

    GenevestigatoriQ3MHC1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009936.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3MHC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276305.
    GeneTreeiENSGT00390000008314.
    HOGENOMiHOG000280717.
    HOVERGENiHBG061680.
    InParanoidiQ3MHC1.
    OMAiINIFAPP.
    OrthoDBiEOG7M0NT7.
    PhylomeDBiQ3MHC1.
    TreeFamiTF323980.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3MHC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK    50
    KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS 100
    LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY 150
    ENRDFRQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA 200
    LANLSPCSIP HRIYRQAHSL LCSFLPWSSI SSKGGIEYSR TM 242
    Length:242
    Mass (Da):27,493
    Last modified:October 25, 2005 - v1
    Checksum:iF2307DFB07F13F84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321S → T in AAP83441. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316589 mRNA. Translation: AAP83441.1.
    BC105304 mRNA. Translation: AAI05305.1.
    RefSeqiNP_001014248.2. NM_001014226.2.
    UniGeneiRn.13255.
    Rn.201091.

    Genome annotation databases

    EnsembliENSRNOT00000009936; ENSRNOP00000009936; ENSRNOG00000007280.
    ENSRNOT00000075238; ENSRNOP00000064770; ENSRNOG00000007280.
    GeneIDi363545.
    KEGGirno:363545.
    UCSCiRGD:1308915. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316589 mRNA. Translation: AAP83441.1 .
    BC105304 mRNA. Translation: AAI05305.1 .
    RefSeqi NP_001014248.2. NM_001014226.2.
    UniGenei Rn.13255.
    Rn.201091.

    3D structure databases

    ProteinModelPortali Q3MHC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009936 ; ENSRNOP00000009936 ; ENSRNOG00000007280 .
    ENSRNOT00000075238 ; ENSRNOP00000064770 ; ENSRNOG00000007280 .
    GeneIDi 363545.
    KEGGi rno:363545.
    UCSCi RGD:1308915. rat.

    Organism-specific databases

    CTDi 79903.
    RGDi 1308915. Naa60.

    Phylogenomic databases

    eggNOGi NOG276305.
    GeneTreei ENSGT00390000008314.
    HOGENOMi HOG000280717.
    HOVERGENi HBG061680.
    InParanoidi Q3MHC1.
    OMAi INIFAPP.
    OrthoDBi EOG7M0NT7.
    PhylomeDBi Q3MHC1.
    TreeFami TF323980.

    Miscellaneous databases

    NextBioi 683635.
    PROi Q3MHC1.

    Gene expression databases

    Genevestigatori Q3MHC1.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GNAT family mRNA in the developing rat ovary."
      Luna F., de la Chesnaye E., Ojeda S.R.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Ovary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiNAA60_RAT
    AccessioniPrimary (citable) accession number: Q3MHC1
    Secondary accession number(s): Q7TMZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3