Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3MHC1 (NAA60_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 60

EC=2.3.1.48
EC=2.3.1.88
Alternative name(s):
GNAT acetyltransferase
N-acetyltransferase 15
NatF catalytic subunit
Gene names
Name:Naa60
Synonyms:Nat15
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activity

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Golgi apparatus membrane By similarity.

Post-translational modification

Acetylated: autoacetylation is required for optimal acetyltransferase activity By similarity.

Sequence similarities

Belongs to the acetyltransferase family. NAA60 subfamily.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242N-alpha-acetyltransferase 60
PRO_0000321568

Regions

Domain13 – 182170N-acetyltransferase

Amino acid modifications

Modified residue791N6-acetyllysine; by autocatalysis By similarity
Modified residue1051N6-acetyllysine; by autocatalysis By similarity
Modified residue1091N6-acetyllysine; by autocatalysis By similarity
Modified residue1211N6-acetyllysine; by autocatalysis By similarity

Experimental info

Sequence conflict2321S → T in AAP83441. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3MHC1 [UniParc].

Last modified October 25, 2005. Version 1.
Checksum: F2307DFB07F13F84

FASTA24227,493
        10         20         30         40         50         60 
MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK KFFSLAATYR 

        70         80         90        100        110        120 
GAIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS LGVVKEFRKH GIGSLLLESL 

       130        140        150        160        170        180 
KDHISTTAQD HCKAIYLHVL TTNNTAINFY ENRDFRQHHY LPYYYSIRGV LKDGFTYVLY 

       190        200        210        220        230        240 
INGGHPPWTI LDYIQHLGSA LANLSPCSIP HRIYRQAHSL LCSFLPWSSI SSKGGIEYSR 


TM 

« Hide

References

« Hide 'large scale' references
[1]"GNAT family mRNA in the developing rat ovary."
Luna F., de la Chesnaye E., Ojeda S.R.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Ovary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY316589 mRNA. Translation: AAP83441.1.
BC105304 mRNA. Translation: AAI05305.1.
RefSeqNP_001014248.2. NM_001014226.2.
UniGeneRn.13255.
Rn.201091.

3D structure databases

ProteinModelPortalQ3MHC1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009936; ENSRNOP00000009936; ENSRNOG00000007280.
ENSRNOT00000075238; ENSRNOP00000064770; ENSRNOG00000007280.
GeneID363545.
KEGGrno:363545.
UCSCRGD:1308915. rat.

Organism-specific databases

CTD79903.
RGD1308915. Naa60.

Phylogenomic databases

eggNOGNOG276305.
GeneTreeENSGT00390000008314.
HOGENOMHOG000280717.
HOVERGENHBG061680.
InParanoidQ3MHC1.
OMAINIFAPP.
OrthoDBEOG7M0NT7.
PhylomeDBQ3MHC1.
TreeFamTF323980.

Gene expression databases

GenevestigatorQ3MHC1.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio683635.
PROQ3MHC1.

Entry information

Entry nameNAA60_RAT
AccessionPrimary (citable) accession number: Q3MHC1
Secondary accession number(s): Q7TMZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 25, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families