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Q3MHC1

- NAA60_RAT

UniProt

Q3MHC1 - NAA60_RAT

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Protein

N-alpha-acetyltransferase 60

Gene

Naa60

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. chromosome segregation Source: UniProtKB
  3. histone H4 acetylation Source: UniProtKB
  4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
GNAT acetyltransferase
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:Naa60
Synonyms:Nat15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1308915. Naa60.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791N6-acetyllysine; by autocatalysisBy similarity
Modified residuei105 – 1051N6-acetyllysine; by autocatalysisBy similarity
Modified residuei109 – 1091N6-acetyllysine; by autocatalysisBy similarity
Modified residuei121 – 1211N6-acetyllysine; by autocatalysisBy similarity

Post-translational modificationi

Acetylated: autoacetylation is required for optimal acetyltransferase activity.By similarity

Keywords - PTMi

Acetylation

Expressioni

Gene expression databases

GenevestigatoriQ3MHC1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009936.

Structurei

3D structure databases

ProteinModelPortaliQ3MHC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiQ3MHC1.
OMAiINIFAPP.
OrthoDBiEOG7M0NT7.
PhylomeDBiQ3MHC1.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3MHC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK
60 70 80 90 100
KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS
110 120 130 140 150
LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY
160 170 180 190 200
ENRDFRQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA
210 220 230 240
LANLSPCSIP HRIYRQAHSL LCSFLPWSSI SSKGGIEYSR TM
Length:242
Mass (Da):27,493
Last modified:October 25, 2005 - v1
Checksum:iF2307DFB07F13F84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321S → T in AAP83441. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316589 mRNA. Translation: AAP83441.1.
BC105304 mRNA. Translation: AAI05305.1.
RefSeqiNP_001014248.2. NM_001014226.2.
XP_008765742.1. XM_008767520.1.
UniGeneiRn.13255.
Rn.201091.

Genome annotation databases

EnsembliENSRNOT00000009936; ENSRNOP00000009936; ENSRNOG00000007280.
ENSRNOT00000075238; ENSRNOP00000064770; ENSRNOG00000007280.
GeneIDi363545.
KEGGirno:363545.
UCSCiRGD:1308915. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316589 mRNA. Translation: AAP83441.1 .
BC105304 mRNA. Translation: AAI05305.1 .
RefSeqi NP_001014248.2. NM_001014226.2.
XP_008765742.1. XM_008767520.1.
UniGenei Rn.13255.
Rn.201091.

3D structure databases

ProteinModelPortali Q3MHC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009936 ; ENSRNOP00000009936 ; ENSRNOG00000007280 .
ENSRNOT00000075238 ; ENSRNOP00000064770 ; ENSRNOG00000007280 .
GeneIDi 363545.
KEGGi rno:363545.
UCSCi RGD:1308915. rat.

Organism-specific databases

CTDi 79903.
RGDi 1308915. Naa60.

Phylogenomic databases

eggNOGi NOG276305.
GeneTreei ENSGT00390000008314.
HOGENOMi HOG000280717.
HOVERGENi HBG061680.
InParanoidi Q3MHC1.
OMAi INIFAPP.
OrthoDBi EOG7M0NT7.
PhylomeDBi Q3MHC1.
TreeFami TF323980.

Miscellaneous databases

NextBioi 683635.
PROi Q3MHC1.

Gene expression databases

Genevestigatori Q3MHC1.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GNAT family mRNA in the developing rat ovary."
    Luna F., de la Chesnaye E., Ojeda S.R.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiNAA60_RAT
AccessioniPrimary (citable) accession number: Q3MHC1
Secondary accession number(s): Q7TMZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 25, 2005
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3