ID   PUR7_ANAVT              Reviewed;         245 AA.
AC   Q3MH17;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=Ava_0093;
OS   Anabaena variabilis (strain ATCC 29413 / PCC 7937).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.;
RT   "Complete sequence of Anabaena variabilis ATCC 29413.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
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DR   EMBL; CP000117; ABA19719.1; -; Genomic_DNA.
DR   RefSeq; YP_320614.1; -.
DR   GeneID; 3683446; -.
DR   GenomeReviews; CP000117_GR; Ava_0093.
DR   KEGG; ava:Ava_0093; -.
DR   NMPDR; fig|240292.3.peg.414; -.
DR   HOGENOM; Q3MH17; -.
DR   OMA; Q3MH17; TAFNAQK.
DR   BioCyc; AVAR240292:AVA_0093-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxam...; IEA:HAMAP.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00137; -; 1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR001636; SAICAR_synt.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   PANTHER; PTHR11609; SAICAR_synt; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   ProDom; PD003043; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   CHAIN         1    245       Phosphoribosylaminoimidazole-
FT                                succinocarboxamide synthase.
FT                                /FTId=PRO_1000018662.
SQ   SEQUENCE   245 AA;  27756 MW;  9DB5C26469291178 CRC64;
     MSVHSKLYEG KAKILYTTDE PEVLLADFKD DATAFNAQKR GSILGKGRIN CSISSQLFQQ
     LEASGIKTHF IDSPSPNQMR VKAVKIIPIE VVIRNIAAGS LSQQTGIELG TVLKQPLVEF
     YYKNDQLGDP LLTRDRLLLM ELATAEQVEE ITHLALQIND FLKNFWQNCG ITLVDFKLEF
     GLDSQQQILL ADEISPDTCR LWNTTEADPN RRVMDKDRFR RDLGNVEDAY QEVLQRVLTA
     VEIKN
//