Reviewed, UniProtKB/Swiss-Prot Q3MH17 (PUR7_ANAVT)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Ava_0093

Organism

Anabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]

Taxonomic identifier

240292 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Anabaena

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018662

Sequences

	Sequence		Length	Mass (Da)
	Q3MH17-1 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 9DB5C26469291178	FASTA	245	27,756
	10 20 30 40 50 60 MSVHSKLYEG KAKILYTTDE PEVLLADFKD DATAFNAQKR GSILGKGRIN CSISSQLFQQ 70 80 90 100 110 120 LEASGIKTHF IDSPSPNQMR VKAVKIIPIE VVIRNIAAGS LSQQTGIELG TVLKQPLVEF 130 140 150 160 170 180 YYKNDQLGDP LLTRDRLLLM ELATAEQVEE ITHLALQIND FLKNFWQNCG ITLVDFKLEF 190 200 210 220 230 240 GLDSQQQILL ADEISPDTCR LWNTTEADPN RRVMDKDRFR RDLGNVEDAY QEVLQRVLTA VEIKN

References

[1]

"Complete sequence of Anabaena variabilis ATCC 29413." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000117 Genomic DNA. Translation: ABA19719.1.
RefSeq	YP_320614.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3683446.
GenomeReviews	Gene locus Ava_0093 in contig CP000117_GR.
KEGG	ava:Ava_0093.
NMPDR	fig|240292.3.peg.414.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3MH17.
OMA	Q3MH17. TAFNAQK.
Enzyme and pathway databases
BioCyc	AVAR240292:AVA_0093-MON.
Family and domain databases
HAMAP	MF_00137. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_ANAVT

Accession

Primary (citable) accession number: Q3MH17

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)